We are pleased to present detailed biographies of each editor comprising the Medical Veritas Editorial Board alphabetized by last name.
Editor (Edinburgh, United Kingdom)
Dr. Amet is trained as a neuroscientist (brain development, brain ischemia and epilepsy), and has worked in Edinburgh, Oxford and Princeton before being fully involved with a home-education and treatment of her son affected by autism. Currently, Dr Amet has recently opened the ATT clinic in Edinburgh UK, working with a medical doctor and psychologist ABA therapist to proive biomedical testing and treatments together with educational support and psychological monitoring of treatment outcomes. Dr. Amet is involved in several autism research projects, on both medical/scientific and educational issues. Dr Amet has over the past three years organized and contributed to several conferences and events on autism, the latest being organized together with ATT and Ariane, Treating Autism, held at the Royal College of Physicians in Edinburgh, in October 2005. Dr. Amet has recently received DAN! accreditation. She is also doing a Masters in Special Education - Autism at the University of Birmingham. She has also been involved in promoting art expression from children with autism and has organized several art exhibitions in Edinburgh on the subject. Her work made from her son’s early drawing has been published in Artism in Canada.
2005- 2006 Postgraduate diploma (Master), Special Education Autism Children, Birmingham University. Second year.
2004-2005 Postgraduate diploma (Master), Special Education Autism Children, Birmingham University.
1998-2002 Post-doctoral position, Fujisawa Institute of Neuroscience Edinburgh, Apoptosis in brain ischemia and neurodegenerative disorders.
1994-1998 Post-doctoral position, Princeton Univ., USA. Roles played by the conserved Midkine secreted molecules in brain development and synaptic plasticity.
1990-1994 D.Phil. Oxford University, UK. Thesis entitled: The role of the subcellular localisation of HIV-1 Tat protein in viral gene expression. Thesis supervisor Dr. S. Kingsman. Financial support: British Biotechnology Plc. Oxford, UK.
1989-1990 Diplome d’Etude Approfondies (DEA) in Molecular Biology, University of Strasbourg, France: Cloning of equine EGF.
1988-1990 Diplome d’Ingenieur en Biotechnologie, Ecole Superieure de Biotechnologie (E.S.B.S), Strasbourg, France.
1987-1988 Maitrise de Biochimie, Univ. of Strasbourg, France.
1986-1987 Licence de Biochimie, Univ. of Strasbourg, France.
1984-1986 Diplome d’Etude Universitaire Generales biologie, D.E.U.G. B, University of Strasbourg, France.
1984 Baccalaurèat, serie D (Science), Nancy, France.
Autism
· In the process of setting up an Autism Treatment clinic with the charity Autism Treatment Trust (former Action Against Autism). Principal Scientist.
· Received DAN! (Defeat Autism Now) doctor accreditation, Dec., 2005.
· Initiated and organised with Action Against Autism a conference called Treating Autism, Edinburgh UK, October 14-15, 2005.
· Participated to two clinic days with Dr. McCandless and Dr. Usman (16 children with autism). October 16-17, 2005.
· Initiated a research project: Two UK clusters with very high incidence of autism; exploration into a possible environmental link to heavy metals. L. Amet (PI), G. Bell, B. Pease, K. Aitken.
· Organised an Autism Family summer vacations in France for 2 weeks, each year, with a total of 12 families with children with autism (1 week with French families, 1 week with British families).
· Elected as chairman of ART (Autism Research Treatment)/ subgroup of Action Against Autism.
· Elected secretary Ariane- Research treatments in autism, France Paris, Feb., 2005. Chairperson Dr. Skorupka.
· Publication joint art work from my son and I in Artism, Canada. Artism is a compilation of masterpieces from artists within the AutismToday™ including works by Mark Rimland, Donna Williams.
· Elected on the board of Directors of Action Against Autism—Research treatments Intervention in autism. Chairman Bill Welsh. May, 2004.
· Home education of son affected by autism (Son-Rise, moving on to Growing Minds, ABA and VB).
2001 Autism Conference, Aberdeen- Organised by Strathclyde University.
1999 Cold Spring Harbor Laboratory, 1999 Summer Course: Molecular Mechanisms of Human Neurological Diseases, June 24-30, 1999.
1991 Advanced course on subcellular fractionation and immunoelectron microscopy, Oslo University.
[2] Amet L. Detailed assessment of communication skills of a child with autism, a parent perspective. University of Birmingham, Good Autism Practice, 2005 May; 16(1):57–70.
[3] Nataf R, Skorupka C, Lam, Alain, Springbett A, Amet L, Lathe R. Porphyrinuria in childhood autism. Manuscript Subitted Toxicol Appl Pharmacol., 2006;
[4] Kerr LE, McGregor AL, Amet LE, Asada,T, Spratt C, Allsopp TE, Harmar AJ, Shen,S, Carlson G, Logan N, Kelly JS, Sharkey J. Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia. Cell Death.Differ, 2004; 11 (10):1102–11.
[5] Amet LE, Lauri SE, Hienola A, Croll SD, Lu Y, Levorse JM, Prabhakaran B, Taira T, Rauvala H, Vogt TF. Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci., 2001 Jun;17(6):1014–24.
[6] White MRH, Masuko M, Amet LEA, Elliot G, Braddock, M, Kingsman, AJ, Kingsman SM. Real time analysis of the transcriptional regulation of HIV and hCMV promoters in single mammalian cells. Journal of Cell Science, 1995;108:441–5.
[7] Amet LEA. The role of the subcellular localisation of the HIV-1 Tat protein in viral gene expression. Ph.D. Thesis, 1995.
[8] Stewart F, Power CA, Lennard SN, Allen WR, Amet LEA, Edwards RM. Identification of the horse epidermal growth factor (EGF) coding sequence and its use in monitoring EGF expression in pregnant mare. Journal of Molecular Endocrinology, 1994;12(3): 344–50.
[9] Amet LEA, White MRH, Sutton JA, Caspey LJ, Braddock M, Kingsman AJ, Kingsman SM. Quantitative localisation of HIV proteins in mammalian cells. In Biotechnology Application of Microinjection, Microscopic Imaging and Fluorescence, BachP, Poole P, Mottley J, ed., Plenum Press, New York, 1993:173–84.
[10] White MRH, Braddock M, Byles ED, Amet LEA, Kingsman AJ, Kingsman SM. Application of the firefly luciferase reporter gene to microinjection experiment in Xenopus oocytes. In Biotechnology Application of Microinjection, Microscopic Imaging and Fluorescence, Ed. P. Bach, P. Poole and J. Mottley, Plenum Press, New York, 1993:19–28.
· The Attic Salt- Art Exhibition Autism January, 2006.
· Edinburgh International Conference Centre: See The Bigger Picture was a conference on living with learning difficulties- April 2-3, 2003. Mindroom Our Art work: Inside out—autism and perception was presented.
· French Institute: Edinburgh Dec. 2-7, 2002 Organised an Art exhibition with conference on Art Therapy- Prof Colwyn Trevarthen (Psychology, Language Science), Prof Nigel Osborne (Music therapy, Edinburgh U.), Dr. James Roberston (Music therapy, Edinburgh U.), Mr. Simon Willoughby-Booth (Visual therapy, Edinburgh Royal Hospital).
· Round table on Autism, Edinburgh University Sept 02- Organised a meeting with 15 autism professionals, including Raun Kaufman (USA, Option Institute) to discuss key issues for treatments and educational interventions.
· Traverse Theatre: Autism, Inside Out. Art exhibition. Edinburgh May 19 - June 8, 2002.
· Images of a Boy’s Life by Susan Mansfield. The Scotsman, June, 2002.
Sarah J. Buckley, MD
Dr Sarah J Buckley is an Australian-based family physician (GP) with training in GP-obstetrics. Since 1996, she has been writing about pregnancy, birth and mothering for public and professional audiences.
Her writing brings together her medical training and expertise, with her experiences as mother to her four children, all of whom were born at home.
Sarah’s articles are meticulously researched and present solid medical evidence as well as trust and acknowledgement of the natural processes of birth and mothering. She critiques obstetric care from the widest possible perspectives, including medical, anthropological, cultural and intuitive.
Her work has been published in parenting and professional magazines internationally, including Mothering (US); Midwifery Today (US); Journal of Prenatal and Perinatal Psychology and Health (US); MIDIRS midwifery digest (UK); Byron Child (Australia) and Natural Parenting (Australia).
Professional Background and Experience
1978-84 Trained as medical practitioner at University of Otago (Dunedin, New Zealand) and Wellington Clinical School.
1984 Graduated MB, ChB (MD equivalent)
1985 Internship at Nelson Hospital (NZ), general surgery, paediatrics, general medicine, ENT, accident and emergency.
1986 Senior intern at Northland base hospital (NZ) Psychiatry; general surgery; rural medicine; obstetrics
1986 Gained Diploma of Obstetrics, University of Auckland
1987 Family Medicine Training programme in Palmerston North (NZ), including child psychiatry.
1988-97 Worked as family physician/GP in variety of settings in Melbourne Australia, including an inner-city Community Health Centre, a suburban family practice and a homebirth practice.
1993 Attended homebirths as family physician locum
1997 Moved to Brisbane Australia, on long-term leave to raise family and pursue writing career .
Married since 1989 to Nicholas Lennox, Associate Professor in Developmental Disability at University of Queensland
1990 Emma born at home
1993 Zoe born at home, Lotus Birth (non-severance of cord)
1995 Jacob born at home, water birth, Lotus Birth
2000 Maia born at home, unassisted breech birth, Lotus Birth.
1990-2005 Long-term breastfeeding, each child nursed to about age 4
1990-2005 Long-term co-sleeping/family bed.
Sarah’s work has been mainly aimed at a lay audience, and has been published in parenting magazines internationally. Her book, Gentle Birth, Gentle Mothering is due for publication in Sept./Oct., 2005 (see sarahjbuckley.com for more details).
[1] Ultrasound- cause for concern, Nexus Oct-Nov 2002;9(6):17–20,82.
[2] Epidurals—real risks for mothers and babies, Birthkit, autumn 2002:1,10,11.
[3] Drugs in labour—an overview, Midwifery Today, 2004;71;13–20.
[4] Ecstatic birth- nature’s hormonal blueprint for labour, Mothering, March-April 2002:111;51–61.
[5] Undisturbed birth—nature’s hormonal blueprint for ease and ecstasy, JOPPPAH 2003;17(4);261–88.
[6] Doing no harm at birth, Courier Mail, Brisbane, Jan 5, 2002.
[7] Attachment parenting- an introduction, Courier Mail 17 June 1998.
[8] The pleasure of extended breastfeeding, Courier Mail 7 May 1998.
[9] The cosiness of co-sleeping, Newsletter of Nursing Mothers of Australia, winter 1999;35(3);4–5.
[10] Ten tips for safe sleeping, Natural Parenting spring 2003;4;39–40.
[11] The foundations of gentle discipline, Natural Parenting spring 2004:25–9.
[12] Prenatal diagnosis- technological triumph or Pandora’s box? Byron Child Sept-Nov 2004;11:13–20.
[13] Maternity care—risks and benefits, Doctor Q, magazine of the AMA (Australian Medical Association), Dec 2004.
Current professional interests
· Cord clamping, third stage of labour, lotus birth (non-severance of cord)
· Undisturbed birth, hormones of labour
· Impact of obstetric interventions on mother and baby
· Prenatal diagnosis and impact on mother-baby relationship
· Life-long impact of obstetric delivery
Memberships and appointments
· Royal Australian College of General Practitioners
· Australian Medical Association
· Maternity Coalition
· Association for Improvements in the Maternity Services
· Homebirth Australia
· Home Midwifery Association Qld
· Australian Breastfeeding Association
· International College of Spiritual Midwifery
· Association of Prenatal and Perinatal Psychology and Health
· Member of expert panel for Mothering (US) website www. mothering.com
· Involved in political lobbying for improved birth choices for women in Queensland and Australia-wide
On-going interests include nutrition and alternative/complementary health and healing.
Editor (California, United States)
John Jacob Cannell, MD
Dr. John Jacob Cannell currently serves as president of the Vitamin D Council, a non profit corporation working to end vitamin D deficiency. He has been a member of the American Board of Psychiatry and Neurology (No. 037156) since April 1993 and has added qualification in Forensic Psychiatry (No. 41) since December 1994. Dr. Cannel is a member of the American Medical Association (AMA). During his career, Dr. Cannell has dedicated time and effort to halting injustices and inconsistencies in various governmental programs and agencies, including such diverse areas as the following: (1) the “Black Lung” debate, (2) fraudulent testing in public schools, (3) recovered memory scandals, and (4) invalid nutritional claims and standards.
Professional Experience
Current Positions
Forensic consultation; including outpatient assessment, consultation and testimony in civil and criminal mental health proceedings.
Clinical and forensic consultation; including inpatient assessment, consultation and treatment of mentally ill criminal offenders.
Education
Honors/Grants
· Honored for research on educational attainment in school children during psychiatry postgraduate training; School of Medicine Affiliated Hospitals, 1991. University of New Mexico, Albuquerque, NM.
· $48,000 grant, 1989; Continuing research in standardized testing. The Kettering Family Foundation, Dayton, Ohio.
· $25,000 grant, 1988; Continuing research in standardized testing. The Kettering Family Foundation, Dayton, Ohio
· Phi Beta Kappa, 1972; University of Maryland, College Park, Maryland
· Graduated with high honors, 1972; University of Maryland, College Park, Maryland
[1] Vasquez A, Manso G, Cannell J, The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med. 2004 Sep-Oct;10 (5):28-36; quiz 37, 94.
[2] Cannell, J, The Vitamin D Newsletter, www.cholecalciferol-council.com
[3] Cannell J, Hudson J, Pope H. Standards for informed consent in recovered memory therapy. Journal of the American Academy of Psychiatry and the Law, 2001;29(2).
[4] Beahrs J, Cannell J, Gutheil T. Delayed traumatic recall in adults: A synthesis with legal, clinical and forensic recommendations. Journal of the American Academy of Psychiatry and the Law, March 1996.
[5] Educational Resources Information Center, Clearinghouse on Tests, Measurements and Evaluations. Resources in Education, December 1990, Testing Ethics Model Legislation. (Paper presented at the National Council of Measurement in Education annual meeting, Boston, Massachusetts, April 19, 1990.)
[6] Educational Resources Information Center, Clearinghouse on Tests, Measurements Evaluation. Resources in Education, May 1990, The ‘Lake Woebegone’ Report: How public educators cheat on Standardized Achievement Tests.
[7] Friends for Education, 1989, The ‘Lake Woebegone’ Report: How public educators cheat on Standardized Achievement Tests.
[8] Educational Measurement, Issues and Practice, 1989, Vol. 7(4), The `Lake Woebegone' Effect revisited."
[9] Educational Measurement, Issues and Practice, 1988, 7(2), Nationally normed achievement tests in America's public schools.
[10] Friends for Education, 1987, How all 50 states are above the National average.
[11] The Pahlavi Medical Journal, 1976, 7:1–17. The effects of prolonged consumption of wholemeal bread upon metabolism of calcium, magnesium, zinc and phosphorous of two young American adults.
Memberships/Offices/Public Service
Atascadero State Hospital
Atascadero State Hospital
Editor (Australia)
Mark Joseph Donohoe, MB BS
Dr. Donohoe graduated from the Faculty of Medicine at Sydney University in 1980, and has worked in private general practice since 1983.
He has specialized in environmental and nutritional medicine for eighteen years. He is a Fellow of the Australasian College of Nutritional and Environmental Medicine (FACNEM), a member of the Australian Integrative Medicine Association (AlMA), a member of the National Scientific Advisory Committee on Complementary Medicine (NSACCM), and was a member of the NSW Health Claims and Consumer Protection Advisory Committee (HCCPAC) from 2002-4.
In 1994, he was elected founding president of the Australian Comprehensive Medicine Association (ACMA). Its mission was to foster the incorporation of safe and effective complementary and alternative medicine modalities into medical practices in Australia.
In 1998, he was appointed to the editorial board of FACT (Focus on Alternative and Complementary Therapies), an international medical journal reviewing the research and evidence in the field of complementary and alternative medicine.
Dr. Donohoe is currently president of the Natural Health Care Alliance (NHCA), a national umbrella body representing the Natural Healthcare/Complementary Medicine profession, and committed to establishing Australia's first true health care system, based on natural healthcare.
Dr. Donohoe practices with a variety of orthodox and complementary practitioners in Australia's premier integrative medicine practice, YourHealth Manly.
Education and professional appointments
· Faculty of Medicine, University of Sydney, Bachelor of Medicine, Bachelor of Surgery. Graduated 1980
· Inaugural president, Australian Comprehensive Medicine Association. 1994-1997
· Member Royal Australian College of General Practitioners (RACGP) committee for review of complementary and alternative medicine. November 1995
· Fellowship of Australian Society of Environmental Medicine, 1996
· Member of Editorial Board, FACT Journal. University of Exeter UK. 1998-2001
· Fellowship of Australian College of Nutritional & Environmental Medicine. 2001
· Member, NSW Government Health Claims and Consumer Protection Advisory Committee, 2002-2004
· Member National Scientific Advisory Committee on Complementary Medicine (NSACCM), 2003-present
Professional Medical Career
· 2004-present. Medical Practitioner, YourHealth Manly integrative medical practice. Allergy Clinic specialist
· 1996-2004 Referral based medical practice, specialised in environmentally induced illness, allergy, chemical sensitivities and chronic fatigue syndrome. Mosman, Sydney
· 1991-1999 Clinical researcher associated with University of Newcastle (Clinical research and publications in peer reviewed medical literature, primarily related to chronic fatigue syndrome and chemical injury)
· 1992-1994 Referral based specialised medical practice, 17 Cowles Rd, Mosman 1989-1992
· 1989-1992 Medical Director, Environmental Medicine Centre (referral-based, three doctor medical practice specialised in environmental medicine)
· 1989-1992 Medical Director, Special Environment Allergy Clinic, Manly Waters Hospital (inpatient multidisciplinary hospital unit)
· 1986-1990 Medical Consultant, Complementary Medicine Centre, Rushcutters Bay
· 1983-1989 Solo General Practice, Central Coast, NSW
· 1982 Medical Resident & Surgical Registrar, Gosford Hosp ital
· 1980 - 1981 Medical Intern and Resident, Lidcombe Hos pital
Peer Reviewed Medical Publications
[1] Dunstan RH, Donohoe M, Taylor W, Roberts TK, Murdoch RN Watkins JA, McGregor NR. A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome Med J Aust 1995; 163:294–297.
[2] Dunstan RH, Roberts TK, Donohoe M, McGregor NR, Hope D, Taylor WU, Watkins JA, Murdoch RN, Butt H. Bioaccumu/ated chlorinated hydrocarbons and red/white blood cell parameters. Biochem Molec. Med. 1996; 58:77–84.
[3] Roberts TK, McGregor NR, Dunstan RH, Donohoe M, Taylor W, Murdoch RN, Hope D, Zhang S, Butt HL, Watkins JA, Taylor WU. Immunological and haematological parameters in patients with chronic fatigue syndrome. J. Chronic Fatigue Syndrome 1998; 4(4):51–65.
[4] McGregor NR, Dunstan RH, Donohoe MJ, Roberts TK, Butt HL, Watkins JA, Murdoch RN, Taylor WG. Assessment of Plasma Fatty Acids and Sterols in Sudden- and Gradual-Onset Chronic Fatigue SyndromePatients. J Nut Envir Med 2000; 10:13-23.
[5] Evidence-based medicine and shaken baby syndrome: part I: literature review, 1966-1998. Am J Forensic Med Pathol. 2003 Sep;24(3):239–42.
Other medical Publications
[1] The cost of CAM - debates and issues. Donohoe MJ. Journal of Comp Med Jan-Feb 2003:46–8.
[2] Introduction to the indoor environment and health. Donohoe MJ Environment Design Guide, Royal Australian Institute of Architects (RAIA). 1997, revised 2002.
[3] Multiple chemical sensitivities - debate. Donohoe MJ Australian Doctor June 1998.
[4] 1995 Proceedings of the Complementary Medicine in Chronic Fatigue Syndrome National Consensus Conference Donohoe MJ. Editor 1995.
[5] Doctors talk to doctors about CFS. Donohoe MJ. In: Chronic Fatigue. Vayda W. Simon & Schuster 1991:208–231
[6] Environmental Medicine 1991 Seminar Handbook, Donohoe MJ. Ed. Macquarie Health Corp 1991.
Other Publications
[1] Immig J, Corbett A, Donohoe MJ. Application for inclusion of diagnosis of multiple chemical sensitivities (MCS) in lCD-10 (Australia,), March 2002.
[2] Donohoe MJ. From disease care to health care -the place of complementary & alternative medicine in Australia, September 2001.
[3] Donohoe MJ..Multiple chemical sensitivities - State of the Science (Review) Continuing Legal Education, May 2001.
[4] Donohoe MJ. Critique of the Draft Clinical Practice Guidelines for Chronic Fatigue Syndrome. Submission to the RACP Working Group. 1998 and 2000.
[5] Donohoe MJ Scott's Creek storage tunnel vent health risk assessment report, August 1999.
[6] Donohoe MJ. Senate Air Safety Inquiry - submission regarding safety of BAe-146 aircraft, May 1999.
[7] Donohoe MJ.Submission to Cosmetic Surgery Inquiry of Health Care Complaints Commission, 1999.
[8] Donohoe MJ. Community exposure to agricultural chemicals - report on medical issues and summary of medical and toxicological literature. Report commissioned by the Total Environment Centre for mediation in Gunnedah, September 1997.
[9] Donohoe MJ. Centre for Disease Control C'FS diagnostic checklist (from outcomes of the Complementary Medicine in CFS National Consensus Conference), 1995.
[10] Donohoe MJ. AC'MA Directions and opportunities position paper v 2.6, 1994-98.
Editor (Kenya, Africa)
Bonnie S. Dunbar, PhD
Bonnie S. Dunbar was born in 1948 in Sterling, Colorado, USA. She graduated from the University of Colorado (Boulder) with a B.A. in Zoology in 1970 and M.A. in Physiology in 1971. She earned a Ph.D. in Zoology in 1977 at the University of Tennessee (Knoxville) and engaged in postdoctorate work in Biochemistry and Biophysics at the University of California (Davis). Her professional positions include serving in the following capacities:
1. 1971-1973 Scientist, Oceanography Mariculture, Inc. West Palm Beach, Florida.
2. 1973-1975 Staff Scientist, The Harbor Branch Foundation, Smithsonian Institution Marine Laboratory, Fort Pierce, Florida
3. 1978-1981 Staff Scientist, The Population Council, The Rockefeller University, New York, New York.
4. 1981-1984 Assistant Professor, Department of Cell Biology, Baylor College of Medicine, Houston, Texas.
5. 1984-1994 Associate Professor, Department of Cell Biology and Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
6. 1994—2004 Professor, Department of Molecular and Cellular Biology , Baylor College of Medicine, Houston, Texas (Currently Adjunct Professor)
7. 2001-2002 Fulbright Scholar to Africa (Kenya)
8. 2003-Present Honorary Lecturer, University of Nairobi, Kenya
Dr. Dunbar is a member of the following societies: American Association for the Advancement of Science; Society for the Study of Reproduction; Endocrine Society; American Society for Cell Biology; Electrophoresis Society (Charter Member); International Society of Reproductive Immunology; New York Academy of Sciences; The Enzyme Club of New York; American Society of Anatomists; American Society of Reproductive Immunology.
She has served as a member on the editorial boards of Biology of Reproduction, International Journal of Reproductive Immunology, and Journal of Reproductive Immunology. She is a regular reviewer for American Journal of Reproductive Immunology, Biochemistry, Developmental Biology, Electro-phoresis, Endocrinology, Gamete Research, Journal of Cell Biology, Journal of Clinical Endocrinology and Metabolism, Journal of Experimental Biology and Medicine, Journal of Fertility and Sterility, Journal of Histochemistry and Cyto-chemistry, Journal of Reproduction and Fertility, Obstetrics and Gynecology, Science, Molecular Endocrinology, Molecular Reproduction, and BioTechniques.
1978-1981 The Population Council, The Rockefeller University - Policy Impact Committee.
1983 Society for the Study of Reproduction - Education Committee.
1982-1986 Baylor College of Medicine, Animal Resources Committee: Chairman of Subcommittee for Internal Facility Inspection for NIH Reports; Subcommittee for Satellite Animal Facility. Committee for Publicity on Animal Research. (Including professional media training by Ogilvy & Mather Public Relations)
1984-1985 Society for the Study of Reproduction - Program Committee.
1984-1986 CBH - Graduate Student Advisory Panel (Chairman 1985-1986)
1984-1985 World Health Organization Task Force and Advisory Panel on Reproductive Immunology; World Health Organization Site Visit Team, Family Planning Institute, Guangzhou, China.
1986-1989 Graduate Student Admissions Committee.
1985-1997 Baylor College of Medicine Patent and Copyright Committee, Chairman, Subcommittee on Technology Transfer Policies.
1983-1987 Society for the Study of Reproduction - Reproductive Cell Biologists (Chairman); Program Committee; Education Committee.
1987 NIH Special Study Section on Immunological Contraceptive Development.
1987 NIH Study Section on Shared Instrumentation (Ad Hoc member).
1988 NIH Study Section on University-Industry grant (SIBR) project (Chairman).
1988-1990 National Science Foundation Study Panels, Regulatory Biology, Training Grant Program.
1988 NIH Study Special Study Section on Reproductive Biology
1990 Committee for Evaluation of Medical Student Liaisons
1990 Chairman, Committee of LCME Evaluation of Immunology and Microbiology
1991 NIH Site visit team for Technology Development panel.
1991 Medical Research Council of Canada, Site visit team for center project on reproductive biology.
1991 NIH Study section for Interinstitutional Contraceptive Center Projects
1991 NIH Study section for Prostate Cancer Center evaluation
1991 NIH Review Panel Site Visit - Harvard University Population Centers Grant
1991-1992 Ad hoc reviewer, USDA Reproductive Sciences Division
1993 NIH Study Panel, Molecular Immunology of Sexually Transmitted Diseases
1993-1995 Baylor College Medicine, Medical School Curriculum Retreat Committee, Extramural Graduate School committee, Cell Biology Graduate Student, Education committee, Adopt a Graduate Student Committee; Graduate, School Curriculum Committee; High School Summer Science Student Committee
1994-1999 NIH Study Section of Reproductive Biology- Regular Member
1997 Advisor to National Institute of Health Contraceptive Development Branch
1999 NIH Working group on Global Health Issues
1999-2002 Advisor for NIH Joint working group for US/Indo Program (invited organizer of workshop in New Delhi, 2002 on role of Reproductive Tract in Sexually Transmitted Diseases)
• Award for best paper and presentation, Southwest Developmental Biology Symposium, Atlanta, GA, 1973.
• Honorary Advisor to Guang Zhou Committee of Science and Technology, City Government of Guang Zhou, 1984.
• World Health Organization Advisory Panel, 1984-1988. repeat Site Visits of Institutes in Guangzhou, Chengdu and Beijing, China.
• Nominated from Baylor College of Medicine for PEW Scholar Award.
• Participant in NIH-Reagan-Ghandi Initiative Program.
• Thesis Advisor for Graduate (M.D., Ph.D.) Student (Kenneth Washenik) who won 1987 award for the American Medical Association for Overall Excellence of Research and the Mead Johnson Excellence of Research Award for Graduate Student Division at the 28th Annual National Student Research Forum.
• Nominated for Director of Society for the Study of Reproduction
• Postdoctoral fellow (Dr. Vaughn Lee) nominated for Young Investigator Award - Society for the Study of Reproduction. August 1991 meeting.
• Griff T. Ross Memorial Lecturer (National Institutes of Child Health and Development) October, 1991
• American Society of Cell Biology - Summer Fellowship to Sponsor High School Biology, (Two awards for two high school teachers,
• Expert Panel for US Department of Agricultural, Division of Wildlife. May, 1992.
• Workshop speaker for Techniques symposia on techniques, Society for the Study of Reproduction, July, 1992
• Methodist Hospital Oncology Symposia - Award for best clinical research, April, 1993
• Dr. Eric Schwoebel, former graduate student and director of students at the Institute or Primate Research in Nairobi, Kenya. Student of twinning institute award between BCM and the Institute of Primate Research in Kenya, Student, Dr. Mary Oguna awarded “Best young scientist researcher at the Pan-African meeting of Biochemistry and Molecular Biology.
• National Institutes of Health - Honored as First Margaret Pittman Lecturer in recognition of pioneering work on contraceptive vaccine development – (October, 1994).
• Advisory board of scientific research for the National Vaccine Information Center. (1998-present)
• Advisory board of the National Humane Society. (1999- present)
• Founding member of Baylor Research and Science Scholars (BRASS) (1995- present).
• Advisory board of National Institutes of Health on International Development (Sept. 1999).
• US/India Joint working group on Population I – January 2000 – present
• Consultant to the United States Humane Society August 1999 to present
• Fulbright Scholarship to Africa (Kenya) August 2001 to August 2001
Dr. Dunbar has assisted with the following television productions and programs:
• WFAA-TV: American Broadcasting Company affiliate in Dallas, Texas as Association for the Advancement of Science Mass Media Intern (1976).
• Cancer: The Clues in the Cell, B. Dunbar, Writer, Producer, and Narrator (30 minute documentary). WFAA, 1976
• Children's Series on "Biology of the Cell" and "Marine Biology" for the Mr. Peppermint Show. B. Dunbar, Producer (10 programs). WFAA, 1976
• Live Morning Talk Shows on Medical Research, WFAA, 1976
• Channel 8: Joyce Gay Report - Interview, Houston, Texas, September, 1990
• Channels 2, 11, 29. Multiple evening news reports - Houston, Texas, 1991-1998. ABC affiliate, Miami, 1998 (Emmy award winning series on adverse reactions to Hepatitis B vaccine.
• Discovery Channel - Beyond 2000 - 20 min. segment on contraceptive vaccine research and interview (International - US 1993)
• Interview for ABC 20/20 on autoimmune reactions following Hepatitis B vaccination and viral molecular mimicry and autoimmune diseases
Patent and patient expert witness experience includes the following:
• Method of Preparation and Use for Zona Pellucida Antigens and Antibodies for Sterilization and Contraception (Patent #4,996,297 issued, 1991)
• Monoclonal antibody for diagnostic and therapeutic use in ovarian cancer. (patent issued 1995)
• Contraceptive vaccine comprising a glycosylated 55 kDa zona pellucida protein immunogen and method of use of the same in contraception (Patent #US5,637,300, 6/10/97)
• Methods of preparation and use for zona pellucida antigens and antibodies for sterilization and contraception (Patent # 5820863 issued 10/13/1998)
• Expert witness for Praxis/American Cyanamide. Successful defense of patent on Hibtiter vaccine
1. Dunbar BS. (sole author) (1987) Two-Dimensional Gel Electrophoresis and Immunological Techniques, 372 pages, Plenum Press, New York. (over 6000 copies sold) (Edition Two, In preparation)
2. Dunbar BS, O'Rand M. (Eds.) (1991) A Comparative Overview of Mammalian Fertilization (23 chapters, Plenum Press, NY).
3. Dunbar BS. (Ed.) (1993) Protein Blotting Techniques. At request of Series Editors R Rickwood and D Hames; IRL Series on Practical Approaches in Biochemistry.
4. Dunbar BS (1995-future) Series Editor on Methods in Cell and Molecular Biology Series, Plenum Press, NY. (2 books currently in print and 4 others in preparation)
[1] Dunbar BS, Shivers CS. Immunological aspects of sperm receptors on the Zona Pellucida of mammalian eggs. Immunol. Commun, 1976;5(5):375-86.
[2] Dunbar BS. Model systems to study the relationship between antibodies to zonae and infertility: Comparison to rabbit and porcine Zonae Pellucidae. Ninth Inter. Cong. on Animal Repro. and Artificial Insemination II, 1980:191–99.
[3] Dunbar BS. Characterization of antibodies to Zonae Pellucidae antigens and their role in fertility. Proceedings of the International Conference on Reproductive Immunology. T Gill, T Wegmann, eds., Oxford Univ. Press, England, 1982:505–35.
[4] Dunbar BS. Morphological, biochemical and immunochemical characterization of the mammalian Zonae Pellucidae. In: Mechanisms of Mammalian Fertilization. J Hartmann, ed., Academic Press, 1982:140–67.
[5] Dunbar BS. Protein analysis using high-resolution two-dimensional polyacrylamide gel electrophoresis. In: Handbook of Molecular Endocrinology. W Schrader, B O'Malley, eds., Houston Biol. Assn, 1983-1987.
[6] Dunbar BS, Wolgemuth D. Structure and function of the mammalian Zonae Pellucidae. In: "Modern Cell Biology", B Satir, ed., Alan R. Liss, New York, publisher, 1984.
[7] Skinner S, Dunbar B. Species variation of the morphological, immunochemical, and biochemical properties of mammalian zonae pellucidae. Fogarty Internat. Center Meeting on Reproductive Immun. P Talwar, ed., Plenum Press, New York, 1986.
[8] Gupta SK, Bhatnagar P, Dunbar BS, Sehgal S. Immunohistological studies during immunization of primates with porcine zona pellucida. Fogarty Internat. Center Meeting on Reproductive Immun. P Talwar, ed., Plenum Press, New York, 1986.
[9] Timmons TM, Dunbar BS. Antigens of mammalian Zona Pellucida. In: Current Concepts in Immunoreproduction. S Mather, CM Fredericks, eds., Hemisphere Publishing Corporation, 1988:242–60.
[10] Timmons TS, Maresh G, Dunbar BS. Protein Analysis using high-resolution two-dimensional polyacrylamide gel electrophoresis. In: Handbook of Molecular Endocrinology. W Schrader, BW O'Malley, eds., Houston Biol. Assoc, 1988.
[11] Schwoebel E, Dunbar BS. Fertility and infertility studies for benefit of animals and man. J. Amer. Vet. Med. Assoc., 1988; 9:193–205.
[12] Washenik K, Skinner S, Maresh G, Dunbar BS. Ovarian development and the formation of the Zona Pellucida. In: The Mammalian Egg Coat: Structure and Function, J Diet, ed., Springer-Verlag, New York: New York, 1989:49–60.
[13] Skinner S, Timmons T, Schwoebel E, Dunbar BS. Zona Pellucida antibodies. In: Fertility and Infertility. Immunology and Allergy Clinics of North America, 1989;10:185–97.
[14] Dunbar BS, Schwoebel E. Preparation of polyclonal antibodies. In: Guide to Protein Purification Techniques. Methods in Enzymology, M Deutcher, ed., Academic Press, New York, 1990; 128:663–9
[15] Dunbar BS, Skinner S. Preparation of monoclonal antibodies. In: Guide to Protein Purification Techniques. Methods in Enzymology, M. Deutcher, ed., Academic Press, New York, 1989;128:670–8.
[16] Timmons T, Dunbar BS. Protein blotting techniques and immunodetection. In: Guide to Protein Purification Techniques. Methods in Enzymology, M Deutcher, ed., Academic Press, New York, 1990; 128:679–87
[17] Dunbar BS. Ovarian antigens and infertility. Am. J. Reprod. Immun, 1989;21:28–31.
[18] Dunbar BS, Washenik K, Skinner S. Methods for the development and use of monoclonal and polyclonal antibodies. In: Handbook of Molecular Endocrinology. W Schrader, BW O'Malley, eds., Houston Biological Assn, 1989 and 1990.
[19] Dunbar BS, Kimura H, Timmons TM. Protein analysis using high resolution two-dimensional polyacrylamide gel electrophoresis. In: Guide to Protein Purification Techniques. Methods in Enzymology, M Deutcher, ed., Academic Press, New York, 1990; 28:441–58.
[20] Dunbar BS, Prasad M, Timmons T. Comparative mammalian Zonae Pellucidae. In: Comparative Overview of Mammalian Fertilization, BS Dunbar, M O'Rand, eds., Plenum Press, 1991:97–114.
[21] Timmons T, Skinner S, Dunbar B. Maturation of the mammalian Zona Pellucida. In: Proceedings of an International Workshop on Gamete Interaction: Prospects for Immunocontraception, N Alexander, AA Acosta, eds., 1991:277–92.
[22] Dunbar BS. Development of contraceptive vaccines. In: NIH Symposium on Contraceptive Development: Opportunities in Contraception: Research and Development. F Hazeltine, K Laguardia, eds.; submitted for publication - proceedings still not published, 1992.
[23] Dunbar BS. Application of immunological contraceptive vaccines in wildlife mannagement. In: Advances in Reproductive Research in Man and Animals. Inst. of Primate Res. National Museums of Kenya; Symposia on: Elephant Demography and Fertility Control, 1994.
[24] Wilkins B, Dunbar BS. Molecular analysis and dissection of antigenic domains of mammalian Zona Pellucida. In: 2nd International Congress on: Advances in Reproductive Research in Man and Animals. (Nairobi, Kenya,) Animal Reproduction. C Bambra, ed., 1994.
[25] Lee V, Dunbar B. Sample preparation of immunoblotting procedures. In: Protein Blotting Techniques (IRL Practical Approach Series) BS Dunbar, ed. Oxford Press, London England, 1993.
[26] Dunbar B. Introduction and basic equipment. In: Protein Blotting Techniques (IRL Practical Approach Series) BS Dunbar, ed., Oxford Press, London England, 1993.
[27] Dunbar BS. Immunocontraception in wildlife management. Symposia on Wildlife Contraception. USDA, 1995.
[28] Dunbar BS. Role of ovarian antigens in fertility and infertility. In: Immunology of Human Reproduction. Kurpisz, Fernandez, eds. BIOS Scientific Publishers LTD, Oxford, England, 1995.
[29] Skinner S, Prasad S, Ndolo R, Dunbar B. Zona Pellucida antigens: targets for contraceptive vaccines. In: International Congress on Zona Pellucida Antigens and Contraception. Gupta, ed. J Fertil. and Steril. J. Reprod, 1996;Suppl. 35(3):163–74.
[30] Ndolo R, Oguna M, Bambra C, Dunbar BS, Schwoebel.E. Immunogenicity of zona pellucida vaccines. In: International Congress on Zona Pellucida Antigens and Contraception. Gupta, ed., J. Fertil. and Steril. J. Reprod. Fertil, 1996;Suppl. 50:151–8.
[31] Prasad SV, Skinner SM, Dunbar BS. Zona Pellucida antigens and the regulation of fertility: An immunocontraceptive approach. In: New Horizzons in Reproductive Medicine, C Coutifaris, L Mastrianni, eds. The International Congres, Symposium and Seminar Series. Vol. 12. The Parthenon Publishing Group, 1997: 129–44.
[32] Dunbar BS, Prasad S, Carino C, Skinner SM. The ovary as an immune target. J Soc Gynecol Investig, 2001 Jan-Feb;8(1 Suppl.):S43–8.
[33] Prasad SV, Skinner SM, Carino C, Wang N, Cartwright J, Dunbar, BS. Structure and function of the proteins of the mammalian Zona pellucida. Cells Tissues Organs, 2000;166(2):148–64.
[34] Dunbar BS, Skinner S, Kaul G, Prasad SM. Molecular approaches for the evaluation of responses to Zona Pellucida and development of second generation ZP vaccines. Reprod. Suppl, 2002; 60:9–18.
[35] Dunbar BS, Skinner SM. The role of the female reproductive system in immunocontraception. In: “The Uterus”. (In Press) 2002.
[36] Dunbar B, Skinner S. Securite et efficacite des vaccines: questions scientifiques en suspens. Les Vaccinenations en question. P Lannoye, ed. Editions Frison-Roche, 2003.
Editor (France)
Marc Girard, MSc, MD
After a first training leading to a MSc in mathematics (partial differential equations), Marc Girard became a MD in parallel of his research on mathematical modelling. He works on drugs mainly as a consultant for pharmaceutical firms, and also practices as a psychotherapist of Freudian obedience. Besides a number of scientific papers, he published also in literary criticism, especially about Flaubert, Balzac, Zola as well as the Grimm’s tales. As a medical expert witness, he has been commissioned by French judges for reporting on most of the litigations involving drugs (growth hormone, diethylstilbestrol, hepatitis B vaccines, cerivastatine, gulf war syndrome, and others). Unprecedented, the resulting harassment exerted on him by some firms (his former clients) has been given some media coverage in France.
Professional Experience
· Research in mathematic modelling:1976-1982
· Project leader in the pharmaceutical industry (R&D): 1982-1987
· Independent consultant (clinical research, drug monitoring, pharmacoepidemiology): since 1988
· Medical expert witness (Drug and biomedical research)
· Psychotherapist
Memberships
· Association Française de Psychiatrie Biologique
· Association of European Psychiatrists
· British Association for Psychopharmacology
· Royal Society of Medicine
· Institut des Textes et Manuscrits Modernes
· Association of European Recognized Experts
Awards
· Médaille d’argent of Paris Medical University (1983)
· Depression Organon’s Award (1987)
Publications
As a number of his reports are secret by Court order and because of repeated litigations by some manufacturers to obtain disciplinary actions against his writings on drugs or pharmaceutical industry (presented as incompatible with the “impartiality” normally expected from an expert…), Dr Girard’s publications corresponds only to a small part of his work.
Scientific papers
[1] Girard M. Vaccination and auto-immunity:reassessing evidence. Medical Veritas, 2005;2(2):549–54.
[2] Girard M. L’intégrisme causal, avatar de l’inégalité des armes? Recueil Dalloz ,2005; 38(7223):2620–1.
[3] Girard M. Produits pharmaceutiques: la défectuosité, entre l’aléa et la faute. Lexbase Hebdo, 2005;182(N8714AIL).
[4] Girard M. Hepatitis B universal vaccination: learning from the French experience. Red Flags. Available online at http://www.redflagsdaily.com /articles/2005_aug10.html
[5] Comenge Y, Girard M. Multiple sclerosis and hepatitis B vaccination: adding the credibility of molecular biology to an unusual level of clinical and epidemiological evidence. Med Hypotheses 2006;66:84–6.
[6] Girard M. Les médicaments. In A. Rogier (éd). Responsabilité médicale. La référence pour les hôpitaux, médecins, juristes. Paris, Eska, 2005:827–43.
[7] Girard M. Les vaccins. In A. Rogier (éd). Responsabilité médicale. La référence pour les hôpitaux, médecins, juristes. Paris, Eska, 2005:845–56.
[8] Girard M, Girard O. Enquête nationale d’activité des experts judiciaires (01/09/03-31/08/04). Experts, 2005;67:56–8.
[9] Girard M. Causalité “certaine” ou causalité suffisante? Lexbase Hebdo 2005, 170(N4831AIR).
[10] Girard M. Autoimmune hazards of hepatitis B vaccine. Autoimmunity Reviews, 2005;4(2):96–100.
[11] Girard M. Vaccines and evidence-based medicine [Letter to the Editor]. Vaccine (sous presse).
[12] Girard M. La brutalisation du corps féminin dans la médecine moderne. CEREC, 2004 Sept; 2004:15–23.
[13] Girard M. Analyses statistiques:hypothèses ou preuves? J Gynecol Obstet Biol Reprod 2004;33:3S27–8.
[14] Girard M. L’environnement, facteur tératogène pour l’expertise. Juris-Classeur, Environnement, 2004;4:9–11.
[15] Girard M, Girard O. Enquête nationale d’activité des experts judiciaires (01/09/02-31/08/03). Experts, 2004;63:55–7.
[16] Girard M. Le « droit à un procès équitable » est menacé. Le Moniteur des Pharmacies 2003;2495:5.
[17] Girard M. Principes de précaution. Techniques Hospitalières, 2003; 673:41–2.
[18] Girard M. Hepatitis B: how to manipulate the media machine. Available online at http://bmj.bmjjournals.com/cgi/eletters/329/7474/1059#87547
[19] Girard M. Misconceptions about misconceptions. Available online at http://bmj.bmjjournals.com/cgi/eletters/329/7463/411#72515
[20] Girard M. Investing in spin doctors. Available online at http://bmj .bmjjournals.com/cgi/eletters/326/7379/45#29415
[21] Girard M, Girard O. Enquête nationale d’activité des experts judiciaires (01/09/01-31/08/02). Experts, 2003;59:53–5.
[22] Girard M. L’EBM au chevet du malade. Le Courrier de Colo-proctologie, 2002;3:39–40.
[23] Girard M. La vaccination contre l’hépatite B. Les événements de l’année 2001 en dommage corporel (éditions Eska), 2002;63–70.
[24] Girard M. Le retrait de la cérivastatine (« Affaire Bayer »). Les événements de l’année 2001 en dommage corporel (éditions Eska), 2002;59–62.
[25] Girard M. Les effets indésirables des médicaments. Dommage corporel – Expertise médicale, 2002;2 (3):54–8.
[26] Girard M. Santé, thérapeutique et principe de précaution. Experts, 2001;52:19–26.
[27] Girard M. Les principes de l’evidence-based medicine et leur apport à l’exercice de l’expertise judiciaire. Dommage corporel – Expertise médicale, 2001;1(2):29–39.
[28] Girard M. Expertise médicale:questions et ... réponses sur l’imputabilité médicamenteuse. Le Dalloz 2001;16(7025):1251–2.
[29] Girard M. Une médecine fondée sur « l’évidence » ? L’exemple de la demi-vie des antidépresseurs. Actualités en Psychiatrie, 2001;18:84–7.
[30] Girard M. Antidépresseurs et « syndrome d’interruption brutale »:une évaluation pharmacoépidémiologique. La Lettre du Pharmacologue, 2000; 14:184–7.
[31] Girard M. Place de la demi-vie dans le rapport bénéfice/risque des antidépresseurs. Actualités en Psychiatrie, 2000;17:154–7.
[32] Girard M. Meta-analysis on recombinant versus urinary follicle stimulating hormone. Human Reproduction, 2000;15:1650–1.
[33] Girard M. Hoemoeopathy. Available online at http://bmj.com/cgi/eletters /321/7259/471#9679
[34] Girard M. Episiotomy and faecal incontinence. Lancet, 1999;354:2169.
[35] Girard M. Episiotomy:a form of genital mutilation. Lancet, 1999;354:595–6.
[36] Girard M. A propos de « Américaines, Françaises, cherchez la différence ! » La Lettre du Gynécologue, 1998; 234:6.
[37] Girard M. Contraceptions orales et sein. In:Sénologie hormonale à l’usage du praticien, J.Y. Pons (éd), Zeneca Pharma, Cergy, 1998; 73–9.
[38] Grillet MH, Girard M. L’Assurance qualité au service de la pharmacovigilance. 18e journées de pharmacovigilance, Bordeaux, 1996.
[39] Girard M. Epidemiological perspectives on alcohol and the law. Lancet, 1996;347:1772.
[40] Girard M. Ear disease and schizophrenia:confounding factors. Acta Psy Scand, 1996;219–20.
[41] Girard M. Inhibiteurs calciques et traitement de première intention dans l’hypertension artérielle essentielle légère ou modérée. La Lettre du Pharmacologue, 1995;9:206–11.
[42] Girard M. Safety of acyclovir in general practice:A review of available data. Pharmacoepidemiol Drug Safety, 1996;5:325–32.
[43] Girard M. Natural family planning. Lancet 1995;346:774.
[44] Girard M. Thromboembolism and the combined oral contraceptive. Lancet 1995;346:317.
[45] Girard M, A Sainte-Croix, D Delaval, M Bonnin. Aciclovir (ZOVIRAX) - Bilan de la tolérance à 10 ans. R.I.C.A.I., Paris, 1994.
[46] Girard M. Retinoids and contraception. Dermatol, 1995;190:90.
[47] Girard M. Voie orale et voie trans- ou percutanée:le point de vue du pharmaco-épidémiologiste. Reproduction Humaine et Hormones, 1995;8:515–26.
[48] Girard M. Durée de la séquence progestative dans l'hormonothérapie substitutive (HTS):l'évidence épidémiologique. Gynécologie Internationale, 1994;3:25–7.
[49] Girard M. Au pays de la pharmacovigilance (analyse des Procédures européennes). D&P Actualités, 1994;5:13–5.
[50] Girard M. Epidémiologie des accidents digestifs dus aux anti-inflammatoires non stéroïdiens. Synoviale, 1993;26:38–40.
[51] Girard M. L'HTA vue par le pharmacoépidémiologiste. Impact Médecin, 1992;229 (suppl).
[52] Girard M. Management of hypertension. J Royal Soc Med, 1991;84:572.
[53] Girard M. Triazolam. Lancet, 1991;337:1483.
[54] Girard M. The safety of angiotensin-converting enzyme (ACE) inhibitors in moderate hypertension. Adv Drug React Toxicol Rev, 1991;3:169–85.
[55] Girard M. Spironolactone:nouvelles données pharmacologiques pour une molécule connue. La Lettre du Pharmacologue, 1991;5:5–11.
[56] Jaillon P, Girard M, Ponsonnaille J. Tolérance électrocardiographique du Bépridil (CordiumR). La Lettre du Pharmacologue, 1991;5:202–6.
[57] Girard M. Trials of homeopathy. Br Med J, 1991;302:727.
[58] Girard M. Mianserin side-effects. Lancet, 1990;336:1439.
[59] Girard M. Evaluation des risques cutanés de la pilule. Ann Dermatol Vénérol, 1990;117:436–40.
[60] Girard M. Miansérine:effets indésirables et sécurité d'emploi. Humeurs, 1990;3:31–3.
[61] Girard M. La place des examens biologiques dans les bonnes pratiques cliniques. Le Quotidien du Médecin, 1989;4382:42.
[62] Girard M. Eloge du réductionnisme. La Recherche ,1989;20:931–2.
[63] Girard M, Biscos-Garreau M. Reliability of data on haematotoxicity of antidepressants. A retrospective assessment of haematological monitoring in clinical studies on tricyclics. J Affective Disorders, 1989;17:153–8.
[64] Biscos-Garreau M, Girard M. Risques et bénéfices comparés des médicaments: problèmes méthodologiques. L'Encéphale, 1988;14:365–9.
[65] Girard M: Oral provocation:limitations. Sem Dermatol 1989;8:192–5.
[66] Girard M. Pilule et cancer:la poursuite du débat. La Recherche, 1989;20:802–3.
[67] Girard M. Trente ans d'antidépresseurs. Le Quotidien du Médecin, 1988;4166:26–8.
[68] Girard M. Perception of drug hazards. Lancet, 1988;ii:857.
[69] Girard M. Haematotoxicity of antidepressants:The need for a reappraisal. British Association for Psychopharmacology: Autumn Meeting, Galway (Irlande), 1988.
[70] Girard M. Les effets indésirables de la pilule. La Recherche, 1988;201:984–90.
[71] Girard M. Looking for a typology of haematological diseases on antidepressants. 4e Congrès européen de l'Association Européenne de Psychiatrie, Strasbourg, 1988.
[72] Girard M. Le rapport risque/bénéfice des médicaments. L'exemple des antidépresseurs. L'Encéphale, 1988;14:97–9 (Travail couronné par l'AFPB:Prix Dépression Organon, 1987).
[73] Girard M. Technical expertise as an ethical form. Towards an ethics of distance. J Med Ethics, 1988;14:25–30.
[74] Girard M. Quality of ADRs. Adv Drug React Ac Pois Rev, 1987;4:231–2.
[75] Girard M. Comparative study of tricyclics and "second generation" antidepressants: a retrospective assessment of their toxicity on blood lines. International Conference on New Directions in Affective Disorders, Jerusalem, 1987.
[76] Girard M, Bossi L, Poulain D. Tentatives de suicide au progabide. La Presse Médicale, 1987;16:681.
[77] Girard M. Les effets indésirables des médicaments. La Recherche, 1987; 185:234–41.
[78] Girard M. Conclusiveness of rechallenge in the interpretation of adverse drug reactions. Br J Clin Pharmacol, 1987;23:73–9.
[79] Girard M. Data quality in post-marketing surveillance. Adv Drug React Ac Pois Rev, 1986;2:87–95.
[80] Girard M. Post-marketing surveillance: an art or a science? Drug Inf J, 1986;20:347–9.
[81] Bassot JM, Girard M, Nicolas MT, Nicolas G. Dynamics of a transient coupling between endoplasmic reticulum paracrystals and plasma membrane. Cell Biology Congr, Budapest, Hungary, 1986.
[82] Girard M. L'affaire Galilée (Lettre). La Recherche, 1985;172:1573.
[83] Bossi L, Girard M, Poulain D. Progabide safety after massive overdose in 4 subjects. 16th Epilepsy Congress, Hamburg, Germany,1985.
[84] Girard M, Palminteri R, Coquelin JP. Pharmacovigilance des traitements antihypertenseurs: exemple du betaxolol (Kerlone). JAMA, 1985 (S 99);10:58–61.
[85] Girard M. Testing the methods of assessment for adverse drug reactions. Adv Drug React Ac Pois Rev, 1984;4:237–44.
[86] Girard M. Incertitudes théoriques et vérités empiriques en pharmacovigilance. Thérapie, 1985;40:257–62.
[87] Chazard M, Girard M. Pharmacovigilance des phases précoces: le puzzle. Thérapie, 1984;39:459–60.
[88] Girard M. L'imputation en pharmacovigilance est-elle fiable? Thérapie, 1984;39:291–6.
[89] Girard M. Les méthodes d'imputation à l'épreuve du syndrome du practolol. (MD thesis).
Editorials – Opinions - Interviews
[1] Girard M. Hepatitis-B-Impfung in Frankreich. Gen-Ethischer Informationsdienst GID, 2005;172:14–9.
[2] Girard M. Les jobards de l’expertise dans l’œil du cyclone. Le Moniteur des Pharmacies, 2005;2597:12.
[3] Girard M. Médicaments:les risques prévisibles. A quand un vaccin contre les analystes financiers? Les Echos, 27/09/05:19.
[4] Girard M. Sacrée papaye. Le Moniteur des Pharmacies, 2005;2569:34.
[5] Girard M. Deroxat:dépression avant la tempête. Le Moniteur des Pharmacies, 2005;2565:39.
[6] Girard M. Les effets indésirables du vaccin contre l’hépatite B. Votre Santé, 2005 (hors série):26–9.
[7] Girard M. Vaccination contre l’hépatite B:pas si simple. Ouest-France, 29/12/04.
[8] Girard M. Le vaccin peut être dangereux chez les bébés. Le Progrès, Nov. 15, 2004:6.
[9] Girard M. Dérive commerciale ou naufrage intellectuel? Le Moniteur des Pharmacies, 2004;2557:45.
[10] Girard M. Le marché de la prévention:un nouvel eldorado. Le Moniteur des Pharmacies, 2004;2552:43.
[11] Girard M. Conscience des pharmaciens:l’heure de la rétrocession? Le Moniteur des Pharmacies, 2004;2548:43.
[12] Girard M. Vraies terreurs et fausses pénuries. Le Moniteur des Pharmacies, 2004;2544:24.
[13] Girard M. Hypnotique ou hypnose ? Le Moniteur des Pharmacies, 2004; 2540:43.
[14] Girard M. Douste qui rit, Blazy qui pleure. Le Moniteur des Pharmacies, 2004;2536:51.
[15] Girard M. Les patients ont bon dos. Le Moniteur des Pharmacies, 2004;2531:42
[16] Girard M. Vaccination et promotion abusive:le retour. Le Moniteur des Pharmacies, 2004;2527:41.
[17] Girard M. Pas de pause pour la ménopause. Le Moniteur des Pharmacies, 2004;2523;35.
[18] Girard M. Risque des vaccins:port du voile obligatoire. Le Moniteur des Pharmacies, 2004;2519:38.
[19] Girard M. Pharmaco-épidémiologie culturelle. Le Moniteur des Pharmacies, 2003;2514:49.
[20] Girard M. Innovation, homéopathie et pornographie. Le Moniteur des Pharmacies, 2003;2510:47.
[21] Girard M. Dépenses de santé:les comptes des contes. Le Moniteur des Pharmacies, 2003;2505:47.
[22] Girard M. L’été de toutes les blagues. Le Moniteur des Pharmacies, 2003;2501:49.
[23] Girard M. Trou de la Sécu:la conjoncture explique-t-elle tout ? Le Moniteur des Pharmacies, 2003;2494:41.
[24] Girard M. Santé publique et politique:le yin ou le yang ? Le Moniteur des Pharmacies, 2003;2489:39.
[25] Girard M. Viagra et seins nus:il fallait oser. Le Moniteur des Pharmacies, 2003;2485:39.
[26] Girard M. Vaccination antiméningococcique:morales au beau fixe. Le Moniteur des Pharmacies, 2003;2481:47.
[27] Girard M. Innovation, quand tu nous tiens… Le Moniteur des Pharmacies, 2003;2477:49.
[28] Girard M. Succès commercial et publicité mensongère. Le Moniteur des Pharmacies, 2003;2473:47.
[29] Girard M. La vigilance ne doit pas être abandonnée à l’Administration. Le Moniteur des Pharmacies, 2002;2469:43.
[30] Girard M. Le patient acteur de la pharmacovigilance ? Le Moniteur des Pharmacies, 2002;2464:44.
[31] Girard M. L’innovation n’est pas une garantie de progrès. Le Point, 2002;1573:94.
[32] Girard M. La rentrée et ses prix. Le Moniteur des Pharmacies 2002; 2460:47
[33] Girard M. L’HTS en mauvaise posture. Le Moniteur des Pharmacies, 2002;2456:51.
[34] Girard M. La Justice, alliée de la santé. Libération, 07/08/2002:5.
[35] Girard M. Le retour du patient. Le Moniteur des Pharmacies, 2002; 2436:14.
[36] Girard M. Evaluer les ré-évaluations ? Le Moniteur des Pharmacies, 2000; 2343:12.
[37] Girard M. L'innovation thérapeutique, critère à géométrie variable. Décision Santé, 1992;16:22–3.
[38] Girard M. Comportements de prescription:l'oeil du pharmacovigilant. Décision Santé, 1991;3:30–1.
[39] Girard M. Quand la médecine se raconte. La Recherche, 1989;20:919.
Literary papers
[1] Girard M. Orphée médecin de campagne – Relire Madame Bovary. Actes du colloque international Jean Améry (Univ. Paris XII - Maison Heinrich Heine), 11/03/05 (in press)
[2] Girard M. Représentation de la causalité chez Zola. In La représentation du réel dans le roman. Paris, Oséa, 2002:173–9
[3] Girard M. Psychanalyse et lisibilité. La lecture littéraire, 1999;3:173–81.
[4] Girard M. Modèles et contre-modèles de l’inconscient. Une lecture freudienne de La Bête humaine. Cahiers Naturalistes, 1998;72:363–75.
[5] Girard M. Orphée médecin de campagne:Bovary au fil de Charles. Eidôlon, 1997;50:229–44.
[6] Girard M. Le défaut fondamental dans Grimm. Légendes et Sagesse, 1996;6:5–24.
[7] Girard M. Grimm:l'amour sans la mort. Nouveau Bizarre 1995;1:97–103.
[8] Girard M. Les souffrance du jeune Flaubert. Apprentissage et rupture chez l'auteur de Madame Bovary. In Mimesis et Semiosis, littérature et représentation. Paris, Nathan, 1992, 65–77.
[9] Girard M. Blanche-Neige et les huit nains. Devenir 1991;3:88–99.
[10] Girard M. Un médecin balzacien à Laval. In Ouest et Romantismes, (G. Cesbron, éditeur), actes du colloque d'Angers, 1990. Angers, P.U. Angers, 1991, 165–73.
[11] Girard M. Regard sur la révolution ou révolution du regard. A propos de Flaubert. In Litterature et Révolutions en France (G.T Harris et P.M. Wetherill, éditeurs), actes du colloque de Manchester, 1989. Amsterdam, Rodopi, 1991:121–32.
[12] Girard M. La fille de personne (A propos du conte de Grimm Jungfrau Maleen). Michigan Germanic Studies, 1987;13:19–40.
Books
[1] Girard M. PCEM I:Annales corrigées - Statistiques 1972-1977. Paris, Editions Médicales et Universitaires, 1977.
[2] Girard M, B Capelle, R Vie Le Sage:PCEM I: Annales corrigées - Statistiques, Physique, Chimie. Paris, E.M.U., 1978.
[3] Girard M. Les contes de Grimm:lecture psychanalytique. Paris, Imago, 1990 (1st edition), 1999 (2nd edition).
[4] Girard M. La passion de Charles Bovary. Paris, Imago, 1995 (Ouvrage publié avec le concours du Centre National du Livre).
[5] Kernbaum S (Ed.). Dictionnaire de médecine Flammarion – 8e édition (in press).
Editor-in-Chief (California, United States)
Gary S. Goldman, PhD
Dr. Gary S. Goldman served nearly 8 years (1995-2002) as research-analyst on the Varicella Active Surveillance and Epidemiological Studies Project conducted by the Los Angeles County Department of Health Services (LADHS), Acute Communicable Disease Control Unit in a cooperative agreement with the Centers for Disease Control and Prevention (CDC).
He graduated with honors from California State Univer-sity, Fullerton, (CSUF) in 1976 with a double major: Bachelor of Science Degree in Computer Science and B.S. Degree in Engineering. In 1980 he served as Vice-President of Systems Development of Cascade Graphics Development where he produced the first microcomputer-based computer-aided drafting (CAD) system prior to the AutoCAD system. Dr. Gilbert McCann, professor emeritus of CalTech, served on the board of directors of this corporation. Gary S. Goldman received a Ph.D. in Computer Science from Pacific Western University in September, 1982. He served as a part-time associate professor at CSUF instructing both graduate and undergraduate courses in programming and statistics, digital logic design and switching theory, and others. In collaboration with a school psychologist, he developed the Goldman-Blake method for remediation of children with specific visual process deficits which was used in an experimental study program at Hope-Haven Hospital, Florida.
Dr. Goldman enjoys heuristic programming (programs based on knowledge or intuition concerning solutions to a problem). His biography is included in Marquis’ 8th Edition 2005-2006 Who’s Who in Science and Engineering and 23rd Edition (2006) of Who’s Who in the World. He founded Medical Veritas International (MVI) Inc. and serves as Editor-in-Chief of Medical Veritas: The Journal of Medical Truth. In January, 2006, Dr. Goldman implemented a medical search engine to index the articles published in Medical Veritas® as well as other journals that presented quality manuscripts, but were not accepted for indexing on Medline/Pubmed by the National Library of Medicine—seemingly due to the fact the journals promoted natural, rather than pharmaceutical and drug interventions. (See www.Pubmednci.com)
Dr. Goldman has served as a reviewer for the Journal of the American Medical Association (JAMA), Vaccine, and The American Journal of Managed Care. In 2006, Dr. Goldman has served as a guest speaker on Radio Liberty where he was interviewed by Dr. Stanley Monteith concerning varicella vaccination. He has also addressed varicella vaccine leading to increased incidence of herpes zoster on AutismOne Radio. Mothering Magazine published “Trading Chickenpox for Shingles” based on Dr. Goldman’s research findings.
Recent publications include epidemiological studies concerning varicella, herpes zoster, and capture-recapture methods:
[1] The impact of vaccination on varicella incidence, conditional on school attendance and temperature, in Antelope Valley, CA. Goldman GS, Glasser JW, Maupin TJ, Peterson CL, Mascola L, Chen RT, and Seward, JF. Presentation by JW Glasser at 16th International Conference on Pharmacoepidemiology (ICPE); Barcelona, Spain; August 22, 2000; Pharmacoepidemiology and Drug Safety, 2000;9(Suppl 1):S67.
[2] Varicella active surveillance: use of capture-recapture methods to assess completion of surveillance data. Peterson CL, Maupin T, Goldman G, Mascola L. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. September 28 - October 1, 1997, Toronto, Canada; Abstract H-111, page 233.
[3] Decline in Varicella Incidence and Hospitalizations in Sentinel Surveillance Areas in the United States, 1995-2000. Seward J, Watson B, Peterson C, Mascola L, Pelosi J, Zhang J, Jumaan A, Maupin T, Goldman G, Perella D, Waites C, Tabony L, Wharton M. The 4th International Conference on VZV, March 3-5, 2001, Oral Presentation, La Jolla, California.
[4] Breakthrough Varicella Cases Since Vaccine Licensure in the Varicella Active Surveillance Project. April 2001 Supplement of Pediatric Research, Presented April 28-May 1, 2001 Pediatric Academic Societies Meeting, Baltimore, Maryland. Galil K1, Watson B2, Peterson C3, Mascola L3, Pelosi J4, Seward J1, Zhang J5, Maupin T3, Goldman G3, Perella D2, Waites C4, Tabony L4, Wharton M1. Centers for Disease Control and Prevention, Atlanta1, GA; Philadelphia Department of Public Health, Philadelphia, PA2; Los Angeles County Department of Health, Los Angeles, CA3; Texas Department of Health, Austin, TX4; Dyntel Corporation, Atlanta, GA5. Publication no. 843.
[5] Knowledge, Attitudes, and Practices of Healthcare Providers Regarding Varicella Vaccination in Sentinel Surveillance Area, 1996, 1997, and 1999. Maupin T, Goldman G, Peterson C, Mascola L, Seward J. Poster Session, April 28-May 1 2001, Pediatric Academic Society Annual Meeting, Baltimore, Maryland.
[6] Varicella epidemiology: six years of active surveillance data following implementation of the varicella vaccination program. Peterson C, Mascola L, Maupin T, Goldman G, Seward J, Presented at the 39th Annual Meeting of the Infectious Diseases Society of America (IDSA), Abstract 943, October 25-28, 2001; San Francisco, California.
[7] Varicella disease after introduction of varicella vaccine in the United States, 1995-2000. Seward JF, Watson BM, Peterson CL, Mascola L, Pelosi JW, Xhang JX, Maupin TJ, Goldman GS, Tabony LJ, Brodovicz KG, Jumaan AO, Wharton M. JAMA 2002;287(5):606–11.
[8] Second varicella infections: are they more common than previously thought? Hall S, Maupin T, Seward J, Jumaan AO, Peterson C, Goldman G, Mascola L, Wharton M. Pediatrics. 2002 Jun;109(6):1068–73.
[9] Varicella Susceptibility Among Adolescents in an Active Surveillance Site. Maupin T, Goldman, G, Peterson C, Mascola L, Seward J, Jumaan A, 36th National Immunization Conference of the CDC, May 1, 2002, Denver, Colorado.
[10] Varicella susceptibility and incidence of herpes zoster among children and adolescents in a community under active surveillance. Goldman G. Vaccine, October 1, 2003;21(27-30):4238–42.
[11] Incidence of herpes zoster among children and adolescents in a community with moderate varicella vaccination coverage. Goldman G. Vaccine, Oct. 1, 2003;21(27-30):4243–9.
[12] Using capture-recapture methods to assess varicella incidence in a community under active surveillance. Goldman G. Vaccine, Oct. 1, 2003; 21(27-30):4250–55.
[13] Cost-benefit analysis of universal varicella vaccination in the U.S. taking into account the closely related herpes-zoster epidemiology. Goldman GS. Vaccine, May 9, 2005;23(25):3349–55.
[14] An investigation of the association between MMR vaccination and autism in Denmark. Goldman GS, Yazbak FE. Journal of American Physicians and Surgeons, Fall 2004;9(3):70–5.
[15] Universal varicella vaccination: Efficacy trends and effect on herpes-zoster. Goldman GS. International Journal of Toxicology, 2005 Jul-Aug; 24(4):205–13.
Books Edited
[1] Orrin M. The Chickenpox Vaccine: A new epidemic of disease and corruption. Goldman GS (ed.). Medical Veritas International Inc. 2006. 296 pages, ISBN 0-9788383-1-9 (paperback); 0-9788383-2-7 (hardcover).
[2] Givner C. INJECTION! Goldman GS (ed.) Medical Veritas International Inc. 2006. 320 pages, ISBN 0-9788383-0-0 (paperback).
Editor (Kentucky, United States)
Boyd E. Haley, PhD
Dr. Haley received his BS in Chemistry / Physics from Franklin College in 1963. After a tour in the U.S. Army he completed his M.S. in Chemistry at the University of Idaho (1967) and his Ph.D. in Chemistry /Biochemistry at Washington State University (1971). He was an NIH Postdoctoral Scholar in the Department of Physiology, Yale University Medical School from 1971 to 1974. His first academic appointment was at the University of Wyoming in 1974 where he was promoted to full professor in 1983. In 1985 he was appointed as the first scientist hired in the Markey Cancer Center at the University of Kentucky with academic appointments as professor in the College of Pharmacy and in the Department of Biochemistry of the University of Kentucky Medical Center. In 1996 he was named Professor and Chair of the Department of Chemistry. He is also co-founder and scientific advisor of Affinity Labeling Technologies, Inc., a biotech company that synthesizes and markets to major research institutes nucleotide photoaffinity analogs for biomedical research. This company has developed a diagnostic marker for Alzheimer’s disease that is currently under development by others.
In the past 17 years Dr. Haley has emphasized studies on the biochemistry of Alzheimer’s disease. His research in the biochemical aberrancies in Alzheimer’s disease also lead to his identifying mercury toxicity as a major exacerbating factor, perhaps even a causal factor for this disease. He was one of the first to propose that the organic-mercury preservative (thimerosal) in infant vaccines was the most likely toxic agent involved in Gulf War Syndrome and autism related disorders. He has followed this up with research that demonstrates that several additional factors (Al3+, certain antibiotics), including testosterone, increase the toxicity of thimerosal. Further, in collaboration with others he has shown using mercury analysis of birth-hair that autistics represent a subset of the population that cannot excrete mercury effectively.
In the past few years Dr. Haley has testified before numerous government agencies on the effects of mercury toxicity from dental amalgams and vaccines. This list includes two times before the Congressional Committee on Government Reform, the Pentagon to Surgeon Generals, the Institute of Medicine of the National Academy of Sciences, and legislative committees of the states of Maine and New Hampshire. In the latter situation, both states enacted legislation requiring dentists to inform patients of the 50% mercury in dental amalgam fillings and the concern of many that emission of mercury from these amalgams affects personal health. This past year he testified before the FDA committee for Review and Analysis of the Literature on the Health Effects of Dental Amalgams and will also present before a new committee of the Institute of Medicine of the National Academy of Sciences regarding vaccines and autism.
Dr. Haley is also a member of the Autism Think Tank of the Autism Association and is on the board of the Swedish Foundation for Metal Biology. He has been invited to present lectures on the subject of mercury toxicity and neurological diseases at international conferences in England, Canada, Italy, Switzerland, Australia, Sweden, France, Germany, New Zealand, Mexico and Denmark.
Education
Institution Year Degree/Area
Franklin College 1963 B.A./Chemistry-Physics
University of Idaho 1967 M.S./Organic Chemistry
Washington State University 1971 Ph.D./Chemistry-Biochemistry
Yale University Medical Center 1971-74 Postdoctoral Fellow
Research and Professional Experience
1963-1964 Research Scholar, Food and Drug Administration.
1964-1966 U.S. Army Medic
1966-1967 Graduate Student, University of Idaho
1967-1971 Graduate Student, Washington State University
1971-1974 Postdoctoral Scholar, Yale University
1974-1979 Assistant Professor, Department of Biochemistry, University of Wyoming, Laramie, WY
1979-1981 Associate Professor, Department of Biochemistry, University of Wyoming, Laramie, WY
1981-1985 Professor, Department of Biochemistry, University of Wyoming, Laramie, WY
1985-1997 Professor of Medicinal Chemistry, College of Pharmacy, University of Kentucky, with joint appointments in Biochemistry & Chemistry
1997-present Chairman & Professor, Department of Chemistry with joint appointment in College of Pharmacy
Professional Organizations, Societies, Honors and Responsibilities
1959 President's Scholarship, Franklin College, Indiana
1962 Chi Beta Phi, Franklin College
1962 James M. Sprague Award - $400 award to outstanding undergraduate junior majoring in science.
1963 Kennedy Scholar, Food and Drug Administration, Washington, D.C.
1970 Sigma Xi
1975 Dreyfus Foundation Visiting Researcher, Enzyme Institute University of Wisconsin
1977 American Society of Biological Chemists
1981 Biophysical Society
1981 Served on NIH Physiological Chemistry Study Section
1981 Research was presented as a “highlight” in NIH report on “Cellular and Molecular Basis of Disease Program”
1984 "TOP" Professor Award, University of Wyoming
1982 Served on NIH Physiological Chemistry Study Section
1983 Served on NIH Physiological Chemistry Study Section
1985 Permanent member NIH Biomedical Sciences, Study Section
1991 Honorary Doctorate in Arts & Sciences, Franklin College
1992 Society for Neuroscience
Grant Support
1975 - 1978 National Institutes of Health, “Application of Photoaffinity Nucleotide Analogs”, $82,000, Prinicipal Investigator
1975 Research Coordination Committee, University of Wyoming $1,800
1978 - 1981 National Institutes of Health, “Application of Photoaffinity Nucleotide Analogs”, $183,696, Prinicipal Investigator
1978 - 1981 Eleanor Roosevelt Cancer Institute Grant, $11,400
1979 - 1983 PHS Research Career Development Award, $185,000
1981 - 1986 National Institutes of Health, “Application of Photoaffinity Nucleotide Analogs”, $434,000, Prinicipal Investigator
1982 ASBC Travel Award to attend 12th IVB Congress, Perth, Australia
1983 - 1984 National Science Foundation, “Melatonin Photoaffinity Probe”, $84,000, Co-Principal Investigator
1983 - 1985 National Institutes of Health, “Epididymal Sperm Nucleotide Binding proteins”, $190,000, Co-Principal Investigator
1985 - 1988 U.S. Army Mycotoxin Photoprobes, $390,000, Co-Principal Investigator
1986 - 1989 NIH, “Forskolin Photoaffinity Probes”, $170,000, Co-Principal Investigator
1986 - 1991 NIH, “Application of Photoaffinity Nucleotide Analogs” $781,661, Principal Investigator
1989 - 1994 NIH, “Nucleotide-Tubulin Interactions in Alzheimer's Disease”, $405,259, Co-Prinicipal Investigator
1990 - 1996 Lexington Clinic Foundation For Medical Education and Research, “Inhibition of Neoplastic Cell Proliferation Through Utilization of Photoactive DNA & RNA Synthesis, $100,000, P.I.
1990 - 1993 Eli Lilly, “Development of a Diagnostic Test for Alzheimer's Disease, $378,000, P.I.
1995 - 1997 Wallace Research Foundation, “Development of Diagnostic Tests Using Nucleotide Photoaffinity Probes”. $109,000 for two years.
1997-1998 Wallace Research Foundation, “Development of Diagnostic Tests Using Nucleotide Photoaffinity Probes”. $74,344.
1997-2000 NIH, “Application of Photoaffinity Nucleotide Analogs”, $378,081, P.I.
1997-1998 Isostent, Inc. “Photoattachment of 32P to angioplastic ballon cathers” $52,000.
1998-2000 Wallace Research Foundation “Studies on the Neurotoxicity of Mercury” $150,000
2000-2001 Wallace Research Foundation “Studies on Mercury Neurotoxic Effects at the Cellular Level” $116,520
2001-2002 Wallace Research Foundation “Vaccine & Thimerosal Toxicity Studies” $112,720
2002-2003 Wallace Research Foundation “Synergistic Neurotoxicity of Thimerosal & other compounds.” $78,720.
2003-2003 Autism Research Institute “Neurotoxicity of Thimerosal” $30,000
2003-2004 Wallace Research Foundation “Vaccine thimerosal exposure and its releationship to Autism” $75,704
2004-2005 Wallace Research Foundation “Synthesis of Biologically Based Mercury Chelators which Cross Cell Membrane and the Blood Brain Barrier” $109,558 Starts December 2004
Teaching Experience
· Introductory Comparative Biochemistry
· General Biochemistry
· Problems and Topics in Biochemistry
· Mercury Toxicity: Chemistry and Biochemistry Involved
· Advanced Problems and Topics in Biochemistry
· Nucleic Acids and Protein Biosynthesis
· Nucleotides in Regulation of Biological Phenomena
· Bioenergetics
· Medicinal Chemistry
· Natural Products and Bio-organics
· Graduate level Biochemistry, Protein Chemistry
Talks Given in 2003
· Wayne State University, Dept. of Chemistry Jan 17th
· Dept. Pediatrics, University of Kentucky, Grand Rounds Speaker Jan 23rd.
· Autism Society of Central Kentucky, Century Methodist Church Jan. 27
· Arizona State University , Department of Bioengineering Feb 23-25
· Mealy Vaccine Conference, Boston MA, March 6-7
· Autism One Political Rally with Congressman Dan Burton, Washington, DC March 19.
· International Academy of Oral & Medical Toxicology, Las Vegas, NV March 28th.
· Autism Society of America/OCC, Pontiac, MI March 29th.
· Zeins’s Dental Conference, Newark, NJ. April 11th.
· Greater Louisville Dental Study Group, Louisville, KY April 16th
· Speaker, UK Chemistry Dept. Awards Ceremony, April 25th.
· Autism One Conference, University of Loyala, Chicago, IL May 3-4
· Expert Witness, Congressional Committee on Government Reform, Dan Burton, Washington, DC May 7-8th
· Speaker, UK Superfund Environmental Project, Paducah, KY (by Sandra Bastin) May 13
· Defeat Autism Now (DAN) Conference, Philadelphia, PE 15-18th May
· Wallace Research Foundation, Phoeniz, AZ May 19-21st
· Wright State University , graduate recruitment seminar, May 23rd
· Swedish Heavy Metals Biology Research Group, June 11-15. I am a board member. Uppsalla, Sweden
· Heavy Metals InstituteTask Force, Washington, DC., 19-22 June
· Missouri University Research Reactor, Columbia, MO, 1-3 July
· Doctors for Disaster Prepardness Conference, Phoeniz, AZ, July 12-13
· Autism One Congressional Press Conference, Washington, DC July 23
· Mercury Medical/Neurotoxicology Conference, NY,NY Sept. 10
· American Board of Clinical Medical Toxicology (ABCMT) St. Louis, MO, Sept. 11
· Italian Congress on Metal Toxicity, Teatro congressi P. d’Abano, Largo Marconi n.1-35031 Abano Terme, Italy.November 7-12. I also served as chairman of one of the sessions.
Invited SymposiumTalks, University Invitations and other presentations given in 2004
· Attorney General’s Office, State of New York 5 January
· TV Interview WBNS-TV Columbus, OH 16 January
· Student ACS section, Lexington, KY 28 January
· NSF Progam Evaluator, Washington, DC 4 February
· NAS Institute of Medicine, 9-10 February
· Dr. Ruth Koslack Talk Show, 11 February
· Congres International Toxicite of the Heavy Metaux, Geneva, Swit zerland 27 February
· Dipartimento Di Scienze Biomolecolari Biotecnologie, University of Milan, Milan, Italy 28 February
· International Academy of Oral Medicine and Toxicology, Arlington, VA, 25-27 March
· Owensburo Country Club, A&S Fund Raiser, Owensburo, KY 15 April
· American Academy of Environmental Medicine, St louis, Mi ssouri, 19 April
· Autism One Conference, Chicago, IL 27-30 April
· Shankland Dental Conference, Columbus, OH, 24 March
· American College for the Advancement of Medicine, Orlando, FL 18-20 May
· TV Interview with CBS News in Washington, DC, 26 May
· Autism One, Chicago Illinois, May 28-30
· Congressional/IOM News Conference, Washington, DC 2 June
· Tennessee Autism Association, Chattanooga, TN 4-5 June
· Presentation to Congressman Patrick Kennedy and other US Congressmen, 16 June
· Presentation to California Legislature on Autism 22 June
· Doctors for Disaster Prepardness Conference 26-28 June
· Attorney General’s Office, State of California, 9-10 August
· University of Louisville, Department of Chemistry, 10 September
· State of California, expert witness, Sacramento, CA 14-16 September
· Tulane University Conference on Mercury Toxicity, New Orleans, LA 24 September
· Washington State University , Department of Chemistry/Biochemistry 25 September
· Autism Research Institute Think Tank Presenter, San Diego, CA 29 September
· Defeat Autism Now Conference, San Diego, CA 30 September
· International Academy of Oral Medicine and Toxicology, Nashville, TN 7-9 October
· Presentation to Senator Grassley and other Congressional members on Autism, Washington, DC., 12 October
· Pikeville College of Osteopathic Medicine, Pikeville, KY 22 October
· TV Interview WLKY of Louisville, KY 27 October
· Auburn University, Defeat Autism Now Mini-Conference, Auburn, AL 5-6 November
· Geneva Center on Autism Conference, Toronto, Canada 11-12 November
Some Selected Publications (Refereed Journals)
[1] Haley B, Yount R. Gamma-fluoradenosine triphosphate.synthesis, properties and interaction with myosin and heavy meromyosin. Biochemistry II, 1972:2863–71.
[2] Haley B, Yount R, Hoffman J. Selective inhibition of divalent metal ion requiring ATPase activity of human red cell ghost by an analog of ATP. The Physiologist, 1973;16:333–4.
[3] Haley B, Hoffman J. Interactions of photo-affinity ATP analog with cation-stimulated ATPase activities of human red cell ghost. Proc. Natl. Acad. Sci, 1974;71:3367–71.
[4] Staros JV, Haley B, Richards FM. Human erythrocytes and resealed ghost: a comparison of membrane topology. J. Biol. Chem, 1974;249: 5004–7.
[5] Pomerantz A, Rudolph SA, Haley B, Greengard P. Photoaffinity labeling of a protein kinase from bovine brain with 8-Azido-adenosine-3', 5'-monophosphate. Biochemistry, 1975;14:3852–7.
[6] Haley B. Photoaffinity labeling of cAMP binding sites of human red blood cell membranes. Biochemistry, 1975;14:3852–7.
[7] Staros JV, Richards FM, Haley B. Photochemical labeling of the cytoplasmic Surface of the membranes of intact human erythrocytes. J. Biol. Chem., 1975;250:8174–8.
[8] Malkinson AM, Krueger BV, Rudolph SA, Casnelli JE, Haley B, Greengard P. Widespread occurrence of a specific protein in vertebrate tissues and regulation by cAMP of its endogenous phosphorylation and dephosphorylation. Metabolism, 1975;24:331–41.
[9] Haley B. Photoaffinity labeling of adenosine 3', 5'-cyclic monophosphate binding sites. Methods in Enzymology, Jacoby and Wilchek, eds., 1976; 46:339–46.
[10] Owens JR, Haley BE. A study of adenosine 3', 5'-cyclic monophosphate binding sites of human erythrocyte membranes using 8-Azido-adenosine-3'-5' cyclic monophosphate. J. Supra. Mole .Structure, 1976;5:91–102.
[11] Skare K, Black JL, Pancoe WL, Haley B. Determination of the cellular location of cyclic nucleotide binding sites using 8-Azido-adenosine-3', 5'-monophosphate, A photoaffinity probe. Arch. Biochem. Biophy, 1977; 180:409–15.
[12] Lau E, Haley B, Barden R. Interactions of a photoaffinity analog of CoA with CoA enzymes. Biochemistry, 1977;16:2581–5.
[13] Owens JR, Haley B. A study of adenosine 3', 5'-cyclic nucleotide binding sites of human erythrocyte membranes using 8-Azido-adenosine 3'-5'-Cyclic Monophosphate. Cell shape and surface architecture: Progress in Clinical and Biological Research, 1977;17:65–76.
[14] Lau EP, Haley B, Barden R. The 8-azidoadenine analog of S-benzoyl (3'-dephospho) coenzyme A-A photoaffinity label for Acyl CoA; Glycine N-Acyltransferase. Biochem. Biophys. Res. Commun, 1977;76:843–9.
[15] Geahlen RT, Haley B. Interactions of a photoaffinity analog of GTP with the proteins of microtubules. Proc. Natl. Acad. Sci, 1977;74:4375–7.
[16] Owens JR, Haley B. Use of photoaffinity nucleotide analogs to determine the mechanism of ATP regulation of a membrane bound, cAMP activated protein kinase. J. Supra. Mole. Structure, 1978;9:57–68.
[17] Czarnecki J, Geahlen RT, Haley B. Synthesis and use of Azido photoaffinity analogs of adenine and guanine nucleotides. Methods in Enzymology, 1979;56:642–53.
[18] Marcus F, Haley B. Inhibition of fructose 1,6-biphosphatase by the photoreactive AMP analog, 8-Azido-AMP. J. Biol. Chem, 1979; 254:259–61.
[19] Geahlen R, Haley B, Krebs EG. Synthesis and use of 8-azidoguanosine 3', 5'-cyclic monophosphate as a photoaffinity label for cyclic GMP-dependent protein kinase. Proc. Natl. Acad. Sci, 1979; 76:2213–7.
[20] Geahlen R, Haley B. Use of GTP Photoaffinity probe to resolve aspects of the mechanism of Tubulin polymerization. J. Biol. Chem, 1979; 254:11982–7.
[21] Haley B. Application of photoaffinity nucleotide analogs to biological membrane research. Selected aspects of cancer-related protein, carbohydrate, lipid and other biochemistry, International Cancer Research Data Bank, 1979:87.
[22] Owens J, Haley B. Mechanism of MgATP regulation of membrane bound type I cAMP activated protein kinase. Transmembrane signaling. Alan R. Liss, Inc. New York, New York, 1979:149–60.
[23] Forrester IT, Schoff PK, Haley BE, Atherton RG. Determination of protein kinase activity in intact mammalian sperm. J. of Andrology, 1980; 1:70.
[24] Briggs F, Norman, Al-Jumaily W, Haley B. Photoaffinity labeling of the (Ca+Mg) ATPase of skeletal and cardiac sarcoplasmic reticulum with [32P-]-8-Azido ATP. Cell Calcium, 1980;1:205–15.
[25] Hoyer P, Owens JR, Haley BE. Use of nucleotide photoaffinity probes to elucidate molecular mechanisms of nucleotide Regulated Phenomena. Annals of New York academy of Science, 1980;346:280–301.
[26] Takemoto DJ, Haley BE, Hanse J, Pinbett P, Takemoto LJ. GTPase from rod outer segments: characterization by photoaffinity labeling and tryptic peptide mapping. Biochem. Biophys. Res. Commun, 1981;102:341–7.
[27] Leichtling BH, Coffman DS, Yaeger ES, Rickenberg HV, Al-Jumaily W, Haley BE. Occurrence of the adenylate cyclase "G-Protein" in membranes of dictyostelium discoidium, Biochem. Biophys. Res. Commun, 1981;102:1187–95.
[28] Schoff PK, Forester IT, Haley BE, Atherton R. A study of cAMP binding proteins on intact and distrupted sperm cells using 8-Azidoadenosine-3', 5'-cyclic monophosphate. J. Supra. Molecular Structure, 1982;19:1–15 .
[29] King MM, Carlson G, Haley BE. Photoaffinity-labeling of the subunit of phosphorylase kinase by 8-Azidoadenosine-5'-triphosphate and its 2', 3' -dialdehyde derivative. J. Biol. Chem, 1982;257:14058–65.
[30] Potter R, Haley BE. Photoaffinity labeling of nucleotide binding sites with 8-Azidopurine analogs. Meth. Enzymol. 1982; 91:613–33.
[31] Hoyer PB, Haley BE. Utilization of nucleotide photoaffinity probes to study protein-nucleotide interactions in cell rractions. J. Cellular Biochemistry, 1983.
[32] Haley B. Development and utilization of 8-Azidopurine nucleotide photoaffinity probes. Federation Proceedings, 1983;42:2831–6.
[33] Khatoon S, Atherton R, Al-Jumaily W, Haley BE. Use of nucleotide photoaffinity probes to study hormone action. Biology of Reproduction, 1983;28:61–73.
[34] Kaiser II, Kladianos DM, Van Kirk EA, Haley BE. Photoaffinity labeling of catechol-o-methyltransferase with 8'-Azido-S-adenosylmethionine. J. Biol. Chem, 1983;258:1747–51.
[35] Abraham K, Haley B, Modak M. Biochemistry of terminal deoxynucleotidyl transferase: 8-Azido ATP as a substrate binding site-directed photoaffinity labeling prob. Biochemistr, 1983;22:4197–203.
[36] Haley BE, Ponstingl H, Doenges KH. Photoaffinity labeling of pure tubulin using 8-Azidoguanosine triphosphate at the b-subunit. Hoppe-Seylers J. Physiol. Chem, 1983;364:1137.
[37] Woody AM, Vader CR, Woody RW, Haley BE. Photoaffinity labeling of DNA-dependent RNA polymerase from E. coli with 8-azidoadenosine-5'-triphosphate. Biochemistry, 1984;23:2843–8.
[38] Owens JR, Haley BE. Synthesis and utilization of [5'-32P]-8-Azidoguanosine-3'-phosphate-5'-phosphate: photoaffinity studies on cytosolic proteins of E. coli. J. Biol. Chem, 1984;259:14843–8.
[39] Pfister KK, Haley BE, Witman GB. The photoaffinity probe 8-azidoadenosine-5'-triphosphate. Selectivity labels the heavy chain of Chlamydomonas 12S Dynein. J. Biol. Chem, 1984;259:8499–504.
[40] Atherton RW, Khatoon S, Schoff PK, Haley BE. A Study of Rat Epididymal Sperm Adenosine-3', 5'-monophosphate-dependent Protein Kinase: Maturation Differences and Cellular Location. Biol. of Reproduction, 1985;32:155–72.
[41] McMurray MM, Hansen JS, Haley BE, Takemoto DJ, Takemoto LJ. Interspecies Conservation of Retinal Guanosine-5'-triphosphatase: Characterization by Photoaffinity Labeling and Tryptic Peptide Mapping. Biochemical Journal, 1985;225:227–32.
[42] Khatoon S, Haley BE, Atherton RW. A comparative analysis of cAMP-dependent protein kinase regulatory xubunits in sea urchin and rat sperm. J. Andrology, 1985;6:251–60.
[43] DeBortoli ME, Issa HA, Haley BE, Cho-Chung YS. Elevated levels of p2l ras protein in hormone-dependent mammary carcinomas of humans and rodents. Bioch. Biophys. Res. Commun, 1985;127:699–709.
[44] Evans R, Haley B, Roth D. Photoaffinity labeling of a viral induced protein from tobacco. J. Biol. Chem, 1985;260:7800–4.
[45] Nunamaker, R.A., Wilson, W.T. and Haley, B.E. Electrophoretic detection of Africanized honey bees (Apis mellifera scutellata) in Guatemala and Mexico based on malate dehydrogenase allozyme patterns. Journal of the Entomological Society, 1985;57:622–31.
[46] Pfister KK, Haley BE, Witman GB. Labeling of Chlamydomonas 18S Dynein polypeptides by 8-Azidoadenosine 5'-Triphosphate, a photoaffinity analog of ATP. J. Biol. Chem, 1985;260:12844–50.
[47] Hoyer PB, Fletcher P, Haley BE. Synthesis of 2', 3'-0-(2,4,6,-trinitrocyclohexadienylidine) guanosine 5'-Triphosphate and study of its inhibitory properties with adenylate cyclase. Arch. Biochem. Biophys, 1986;245:368–78.
[48] Evans RK, Johnson JD, Haley BE. 5'-Azido-2'-deoxyuridine-5'-triphosphate: a novel photoaffinity labeling reagent and tool for the enzymatic synthesis of photoactive DNA. Proc. Natl. Acad. Sci. USA, 1986;83:5382–6.
[49] Jeganathan, A., Richardson, S.K., Mani, R.S., Haley, B.E. and Watt, D.S. Selective Reactions of Azide-substituted a-Diazoamides with Olefins and Alcohols Using Rhodium (II) Catalysts. J. Org. Chem, 1986; 51:5362–7.
[50] Malkinson AM, Haley BE, Macintyre BE, Buthy MS. Changes in pulmonary adenosine triphosphate binding proteins detected by nucleotide photoaffinity labeling following treatment of mice with the tumor-modulatory agent Butylated Hydroxytoluene. Cancer Res, 1986; 46:4626–30.
[51] Evans RK, Haley BE. Synthesis and biological properties of 5-Azido-2'-deoxyuridine-5'-triphosphate: a photoactive nucleotide suitable for making light sensitive DNA. Biochemistry, 1987;26:269–76..
[52] Richardson SK, Jeganathan A, Mani RS, Haley BE, Watt DS. Synthesis and biological activity of C-4 and C-15 Aryl Azide derivatives of anguidine. Tetrahedron Letters, 1987;43:2925.
[53] Droms KA, Haley BE, and Malkinson AM. Decreased Incorporation of the Photoaffinity Probe [g3232P]-8N3 GTP into a 45KD Protein in Lung Tumors. Bioch. Biophys. Res. Commun, 1987;144:591–7.
[54] Karpel, R.L., Levin, V.Y. and Haley, B.E. Photoaffinity Labeling of T4 Bacteriophage 32Protein. J.Biol.Chem. 262, 9359–66 (1987).
[55] Suhadolnik RJ, Li Shi Wu, Sobol Jr. RW, Haley BE. 2-and 8-Azido photoaffinity probes. II. Studies on the binding process of 2-5A synthetase. Biochemistry, 1988;27:8846–51.
[56] Suhadolnik RJ, Kariko K, Sobol Jr. RW, Li Shi Wu, Richenbach NL, Haley BE 2- and 8-Azido photoaffinity probes. I. Enzymatic synthesis, characterization and biological properties of 2- and 8-Azido photoprobes of 2-5A & photolabeling of 2-5A binding proteins. Biochemistry, 1988; 27:8840–6.
[57] Droms KA, Haley BE, Smith GJ, Malkinson AM. Decreased photolabeling of Gsa with [a-32P]8N3-GTP in tumorigenic lung epithelial cell lines: association with decreased hormone responsiveness and loss of contact-inhibited growth. Experimental Cell Research, 1989;182:330–9.
[58] Francis B, Overmeyer J, John W, Marshall E, Haley B. Prevalence of nucleoside diphosphate kinase autophosphorylation in human colon carcinoma versus normal colon homogenates. Molecular Carcinogenesis, 1989;2:168–78.
[59] King SM, Haley BE, Witman GB. Structure of the a and b heavy chains of the outer Arm Dynein from Chlamydomonas Flagella. J. Biol. Chem, 1989;;264:10210–8.
[60] Khatoon, S., Campbell, S.R., Haley, B.E. and Slevin, J.T. Aberrant GTP b-Tubulin Interaction in Alzheimer's Disease. Annals of Neurology, 1989;26:210–5.
[61] Lawson SG, Mason TL, Sabin RD, Sloan ME, Drake RR, Haley BE, Wasserman BP. UDP-glucose: (1,3)-B-glucan synthase from Daucas carota L.: characterization, photoaffinity labeling and solubilization. Journal of Plant Physiology, 1989;90:101–8.
[62] Lewis CT, Haley BE, Carlson GM. Formation of an Intramolecular Cystine Disulfide During the Reaction of 8-Azido-GTP with Cytosolic Phosphoenolpyruvate Carboxykinase (GTP) Causes Inactivation without Photolabeling. Biochemistry, 1989;28:9248–55.
[63] Ho LT, Nie ZM, Mende TJ, Richardson S, Chavan A, Kolaczkowska E, Watt DS, Haley BE, Ho RJ. Modification of adenylate cyclase by photoaffinity analogs of forskolin. J. Second Messengers and Phosphoproteins, 1989;12:209–23.
[64] Wasserman BP, Read SM, Frost DJ, Mason TL, Drake RR, and Haley BE. Potential use of affinity labels in subunit identification studies of (1,3)-b-Glucan synthase. J.Applied Polymer Science Symposium (Proceeding of the Tenth Cellulose Conference, Syracuse, NY). Schuerch C, Timell T, eds.;43:827–37 (1989).
[65] Drake RR, Evans RK, Wolf MJ, Haley BE. Synthesis and properties of 5-Azido-UDP-glucose: development of photoaffinity probes for nucleotide diphosphate sugar binding sites. J. Biol. Chem, 1989;264:11928–33.
[66] Dholakia JN, Francis BR, Haley BE, Wahba A. Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-Azidopurine nucleotides. J. Biol. Chem, 1989; 264:20638–42.
[67] Campbell S, Kim H, Doukas M, Haley B. Photoaffinity labeling of ATP and NAD+ binding sites on recombinant human interleukin-2. Proc. Natl. Acad. Sci, 1990;87:1243–6.
[68] Kim H, Haley B. Synthesis and properties of 2-Azido-NAD+: a study of interactions with glutamate dehydrogenase. J. Biol. Chem, 1990;265: 3636–41.
[69] Drake R, Palamarczyk G, Haley B, Lennarz WJ. Evidence for the involvement of a 35-kDa membrane protein in the synthesis of glucosylphosphoryldolichol. Bioscience Reports, 1990;10:61–8.
[70] Marchase RB, Richardson KL, Srisomsap C, Drake R, Haley BE. Resolution of Phosphoglucomutase and the 62 kDa Acceptor for the Glucosylphosphotransferase. Arch. Biochim. Biophys, 1990;280:122–9.
[71] Salvucci ME, Haley BE. Photoaffinity labeling of ribulose bisphosphate carboxylase/oxygenase with 8-azidoadenosine 5'-triphosphate. Planta 181:287–95.
[72] Salvucci ME, Drake R, Broadbent KP, Haley BE, Hanson KR, McHale NA. Identification of the 64 kilodalton chloroplast stromal phosphoprotein as phosphoglucomutase. Plant Physiology, 1990;93:105–9.
[73] Frost DJ, Read SM, Drake R, Haley BE, Wasserman BP. Identification of the UDPG binding polypeptide of (1,3)-b-glucan synthase from a higher plant by photoaffinity labeling with 5-AzidoUDP-glucose. J. Biol. Chem, 1990;265:2162–7 (1990).
[74] Lin FC, Brown RM Jr, Drake RR, Haley BE. Characterization of cellulose synthase catalytic subunit of acetobacter xylinum using 5-Azido-UDP-glc, a photoaffinity probe. J. Biol. Chem, 1990;265:4782–4.
[75] Salvucci ME, Drake RR, Haley BE. Purification and photoaffinity labeling of sucrose phosphate synthase from spinach leaves. Arch. Biochem. Biophys, 1990;281:212–8.
[76] Chavan AJ, Kim H, Haley BE, Watt DS. A photoactive phosphonamide derivative of GTP for the identification of the GTP binding domain of b-tubulin. Bioconjugate Chemistry,1990;1(5):337–44.
[77] Kwiatkowski S, Crocker PJ, Chavan AJ, Nobuyuki I, Haley BE, Watt, DS. Thiazolidine and thiazoline derivatives of 3-Aryl 3-Trifluormethyl diazirines for the preparation of fluorescent or 35S-Radiolabeled photoaffinity probes. Tetrahedron Lett, 31, 2093-2096 (1990).
[78] Palamarczyk G, Drake R, Haley B, Lennarz WJ. Evidence that the synthesis of glucosylphosphoryl dolichol in yeast involves a 35 kDa membrane protein. Proc. Natl. Acad. Sci, 1990;87:2666–70 .
[79] King S, Kim H, Haley B. Strategies and reagents for photoaffinity labeling of mechanochemical proteins. Meth. Enzymol, 1991;196:449–66.
[80] Kim H, Haley B. Identification of peptides in the adenine ring binding domain of glutamate and lactate dehydrogenase using 2-AzidoNAD+. Bioconjugate Chemistry, 1991;2:1142–7.
[81] Mann D, Haley B, Greenberg R. Photoaffinity labeling of atrial natriurtic factor analog atriopeptin III woith [g32P]8N3GTP. Peptide Research, 1991;4(2):79-83.
[82] Drake RR, Zimniak P, Haley BE, Lester R, Elbein AD, Radominska A. Synthesis and characterization of5-Azido-UDP-glucuronic acid. J. Biol. Chem, 1991;266:23257–60.
[83] Drake RR, Zimniak P, Haley BE, Lester R, Elbein AD, Radominska A. Synthesis and Characterization of5-Azido-UDP-Glucuronic Acid. J. Biol. Chem., 1991;266:23257–60.
[84] Hiestand D, Haley B, Kindy M. Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia. Journal of the Neurological Sciences, 1992;113:31–7.
[85] Salvucci M, Chavan A, Haley B. Identification of peptides for the adenine binding domains of ATP and AMP in adenylate kinase: isolation of photoaffinity labeled peptides by metal chelate chromatography. Biochemistry, 1992;31:4479–87.
[86] Shoemaker M, Lin PC, Haley B. Identification of the guanine binding domain peptide of the GTP binding site of glucagon. Protein Science, 1992;1:884–91.
[87] Doukas M, Chavan A, Gass C, Boone T, Haley B. Identification and characterization of a nucleotide binding site on recombinant Murine granulocyte/macrophage-colony stimulating factor. Bioconjugate Chemistry, 1992;3:484–92.
[88] Segal A, West I, Wientjes F, Nugent J, Chavan A, Haley B, Garcia R, Rosen H,. Scrace G. Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH binding site of the microbicidal oxidase of phagocytes. Biochem. J, 1992;284:781–8.
[89] Hammond D, Haley B, Lesnaw J. Identification and characterization of serine/threonine protein kinase activityIntrinsic to the L protein of vesicular Stomatitis virus New Jersey. Journal of General Virology, 1992; 73:67–75.
[90 Chavan A, Nemoto Y, Narumiya S, Kozaki S, Haley B. NAD+ binding site of clostridium botulinum C3 ADP-ribosyltransferase: identification of peptide in the adenine ring binding domain using 2-Azido NAD+. J. Biol. Chem, 1992;267:14866–70.
[91] Gunnersen DJ, Haley BE. Detection of glutamine synthetase in the Cerebrospinal fluid of Alzheimer's diseased patients: a potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA, 1992;89:11949–53.
[92] Shoemaker M, Haley B. Identification of a guanine binding domain peptide of the GTP binding site of glutamate dehydrogenase: isolation with metal-chelate affinity chromatography. Biochemistry, 1993; 32:1883–90.
[93] Churn SB, Sankaran B, Haley BE, Delorenzo RJ. Ischemic brain injury selectively alters ATP binding of calcium and calmodulin-dependent protein kinase-II. Biochem. Biophys. Res. Comm, 1993;193(3):934–40.
[94] Salvucci M, Rajagopalan K, Sievert G, Haley B, Watt D. Photoaffinity labeling of rubisco activase with ATP-g-benzophenone: identification of the ATP g-phosphate binding domain. J. Biol. Chem, 1993;268:14239–44.
[95] Rajagopalan K, Chavan A, Haley B, Watt D. Bidentate cross-linking reagents: non-hydrolyzable nucleotide photoaffinity probes with two photoactive groups. J. Biol. Chem, 1993;268:14245–53.
[96] Trad C, Chavan A, Clemens J, Haley B. Identification and characterization of an NADH binding site of prolactin with 2-Azido-NAD+. Arch. Biochem. Biophys, 1993;304:58–64.
[97] Chavan A, Ensor C, Wu P, Haley B, Tai H. Photoaffinity labeling of human placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase with [a32P]-2N3NAD+: identification of a peptide in the adenine ring binding domain. J. Biol. Chem, 1993;268:16437–42.
[98] Chavan A, Richardson S, Kim H, Haley B, Watt D. Forskolin photoaffinity probes for the evaluation of tubulin binding sites.Bioconjugate Chem, 1993;4:268–74.
[99] Duhr EF, Pendergrass JC, Slevin JT, Haley B. HgEDTA Complex Inhibits GTP Interactions With The E-Site of Brain b-Tubulin. Toxicology and Applied Pharmacology, 1993;122:273–88.
[100] Jayaram B, Haley B. Identification of peptides within the base binding domains of the GTP and ATP specific binding sites of tubulin. J. Biol. Chem 1994;269 (5):3233–42.
[101] Chavan A, Haley B, Volkin D, Marfia K, Verticelli A, Bruner M, Draper J, Burke C, Middaugh R. Interaction of nucleotides with acidic fibroblast growth factor (FGF-1). Biochemistry, 1994;33:7193–202.
[102] Logan J, Hiestand D, Daram P, Huang Z, Muccio D, Hartman J, Haley B, Cook W, Sorscher E. Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide ninding. J. Clin. Invest, 1994; 94:228–36.
[103] Olcott M, Haley B. Identification of two peptides from the ATP-binding domain of creatine kinase. Biochemistry, 1994;33:11935–41.
[104] Bhattacharyya A, Chavan A, Shuffett M, Haley B. Collins D. Photoaffinity labeling of rat liver microsomal 5a-reductase by 2-Azido-NADP+. Steroids, 1994;59:634–41.
[105] Salvucci M, Chavan A, Klein R, Rajagopalan K, Haley B. Photoaffinity labeling of the ATP binding domain of Rubisco activase and a separate domain involved in the activation of Ribulose-1,5-Bisphosphate carboxylase/oxygenase. Biochemistry, 1994;33:14879–86.
[106] Pendergrass JC, Haley BE. Mercury-EDTA complex specifically blocks brain b-Tubulin-GTP interactions: similarity to observations in Alzheimer’s disease. In: Status Quo and Perspective of Amalgam and Other Dental Materials. International Symposium Proceedings. Friberg LT, Schrauzer GN, eds., Georg Thieme Verlag, Stuttgart-New York, 1995: 98–105.
[107] Doukas M, Chavan A, Gass C, Nickel P, Boone T, Haley B. Inhibition of GM-CSF activity by Suramine and Suramin analogues is correlated to interaction with the GM-CSF nucleotide binding site. Cancer Research 55:5161–3.
[108] Bhattacharyya AK, Chavan AJ, Haley B, Taylor MF, Collins DC. Identification of the NADP(H) binding site of rat liver microsomal 5a-reductase (Isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain. Biochemistry, 1995;34:3663–9.
[109] Chavan A, Gass C, Haley B, Boone T, Doukas MA. Identification of N-Terminus Peptide of Human Granulocyte/Macrophage Colony Stimulating Factor as the Site of Nucleotide Interaction. Biochem. Biophys. Res. Commun, 1995;208(1):390–6.
[110] Shoemaker M, Haley B. Identification of the adenine binding domain peptides of the ADP binding site of glutamate dehydrogenase. Bioconjugate Chemistry, 1996;7:302–10 (1996).
[111] Rajagopalan K, Pavlinkova G, Levy S, Pokkuluri R, Schiffer M, Haley B, Kohler H. Novel unconventional binding site in the variable region of immunoglobulins. Proc. Natl. Acad. Sci, 1996; 93:6019–24.
[112] Pavlinkova G, Rajagopalan K, Muller S, Chavan A, Sievert G, Lou D, O’Tolle C, Haley B, Kohler H. Site-specific photobiotinylation of immunoglobins, fragments and light chain dimers. J. Immunological Methods, 1997;201:77–88.
[113] Pendergrass JC, Haley BE. Inhibition of brain tubulin-guanosine 5’-triphosphate interactions by mercury: similarity to observations in Alzheimer’s diseased brain. In: Metal Ions in Biological Systems V34, Mercury and Its Effects on Environment and Biology, Ch. 16. Sigel H, Sigel A, eds. Marcel Dekker, Inc. 270 Madison Ave., N.Y., N.Y. 10016, 1996.
[114] McGuire M, Carroll LJ, Yankie L, Thrall SH, Dunaway-Mariano D, Hertzberg O, Jayaram B, and Haley B. Determination of the nucleotide binding site within Clostridium symbiosum pyruvate phosphate dikinase by photoaffinity labeling, site-directed mutagenesis, and structural analysis. Biochemistry, 1996;35:8544–52.
[115] Kohler H, Pavlinkova G, Haley B. Immunoglobulin nucleotide binding site: a possible superantigen receptor. In: Human B Cell Superantigens, Zouali M, ed., Chapter 13, 1996:189–94.
[116] Sankaran B, Chavan A, Haley B. Identification of adenine binding eomain peptides of the NADP+ active site within porcine heart NADP+-dependent isocitrate dehydrogenase. Biochemistry, 1996;35:13501–10.
[117] Sankaran B, Clemens J, Haley B. A comparison of changes in nucleotide-protein interactions in the striatal, hippocampus and paramedian cortex after cerebral ischemia and reperfusion: correlations to regional vulnerability. Molecular Brain Research, 1997;47:237–50.
[118] Hensley K, Cole P, Aksenov M, Aksenova M, Bummer PE, Carney JM, Haley BE, Butterfield DA. Oxidatively-Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics. J. of Neurochemistry, 1997;68:2451–7.
[119] Pendergrass JC, Haley BE, Vimy MJ, Winfield SA, Lorscheider FL. Mercury vapor inhalation inhibits binding of GTP to Tubulin in rat brain: similarity to a molecular lesion in Alzheimer’s disease brain. Neurotoxicolog, 1997;18(2):315–24.
[120] Olcott MC, Haley BE. Identification of an Adenine-nucleotide binding site on Interferon-a2. Eur. J. Biochem, 1997;247(3):762–9.
[121] David S, Shoemaker M, Haley B. Abnormal properties of creatine kinase in Alzheimer’s disease brain: correlation of feduced enzyme activity and active site photolabeling with aberrant cytosol-membrane partitioning. Molecular Brain Research, accepted 1997.
[122] Holmes AS, Blaxill MF, Haley B. Reduced levels of mercury in first baby haircuts of Autistic children. International J. of Toxicology, 2003; 22:1–9.
[123] Haley B. The relationship of the toxic effects of mercury to exacerbation of the medical condition classified as Alzheimer’s disease. Nordic J. of Biological Medicine, accepted June-July 2003.
Editor (Illinois, United States)
Betsy Hicks
Betsy Hicks is author of Cooking Healthy Gluten and Casein-Free Food for Children, Betsy is a well respected diet counselor hailed as one of the most innovative teachers of diets free of gluten, casein, soy, corn and much more. Either through IgG/IgE testing or through the use of elimination diets, Betsy helps in customizing each individual’s diet based on blood type, pH, parasite and bacteria presence, and neuropeptide affected foods. Betsy incorporates aspects of the Live Right for Your Type diet by Dr. D’Adamo for protein choices; Body Ecology by Donna Gates for cultured and fermented foods; and the Westin A. Price Foundation for fat customization. In addition to her professional nutritional expertise, Betsy is co-founder and diet counselor of Pathways Medical Advocates and is responsible for overseeing the day-to-day operations and team at Pathways with her husband, pediatrician, John H. Hicks, M.D. She develops and coordinates the public education programs offered by this innovative practice including her radio talk show for the Voice America Health and Wellness Channel and Autism One Radio, and is the Nutritional Advisor to the national non-profit organization Autism One. Betsy is the anchor of The GFCF Diet Comprehensive Video and ongoing community lectures and workshops. The mother of a son with autism, she speaks nationally on dietary and holistic interventions for children and adults with disabilities.
Editor (Costa Rica, Central America)
James A. Howenstine, MD
Dr. James Howenstine attained his M.D. from Northwestern University, Chicago, Illinois in 1954. He had a rotating internship at Indianapolis General Hospital. He served as a Pathology Resident at Chicago Wesley Memorial Hospital and as an Internal Medicine Resident at Veterans Administration Hospital (Denver, CO). From June 1957 to July 1959 Dr. Howenstine served as the Ward Medical Officer for the U.S. Naval Officer in Navy Hospital in Chaleston & Beaufort, South Carolina. He then served as Internal Medicine Resident of Boston City Hospital for one year, followed by a year at the National Institute of Health Fellowship in Renal Disease, University of California Hospital (San Francisco, California).
Dr. James A. Howenstine has served as an Assistant Clinical Professor of Medicine at the University of California Medical School in San Francisco, California from May 1963 through July 1991 during which time he engaged in a private practice in Internal Medicine. He served as head of internal medicine section of Thomas Davis Medical Center for July 1991 through July 1997.
During May 1998, Dr. Howenstine delivered lectures for two hours per day on internal medicine for the podiatry students studying to become physicians at Universidad International de las Americas, Apartado 1447-1002 San Jose, Costa Rica.
Publications
[1] Howenstine JA, Gydesen F. The carcinoid syndrome. Rocky Mountain Medical Journal 1958; 55(4):36–41.
[2] Howenstine JA. Exertion induced myoglobinuria, simulation of acute glomeruonephritis. JAMA 1960;173:494–9.
[3] Howenstine JA, Lee J, Hopper J Jr. The glomerular lesion of polycythemia. Proceedings of the 2nd International Congress of Nephrology, Prague, 1963.
[4] Morris C, Yamauchi H, Palabinskas J, Howenstine JA. Medullary sponge kidney. Am J of Med 1965;38:883–92.
[5] Howenstine JA, Slaton P, Spitalny A, Lee J. Flank pain and hematuria in a young man with renal artery arteriosclerosis. J of Urology 1974, Volume 122.
[6] Howenstine JA, A Physician’s Guide to Natural Health Products that Work. ISBN 0-9705684-8-7. Library of Congress Card No. 2001094553, Miami, FL: Penhurst Books.
[7] Howenstine JA. New ideas about the cause, spread and therapy of lyme disease. Townsend Letter for Doctors and Patients, 2004 Jul; #252:64–7.
Health articles contributed to www.NewsWithViews.com during 2003 to present included the following:
[1] Why you should avoid taking vaccines.
[2] Why do the citizens of the U.S. have such poor health?
[3] Abortions cause breast cancer.
[4] 70% of U.S. citizens lack adequate vitamin D–are you one of them?
[5] Use of CO Q 10 to treat malignancies.
[6] Why you probably have hypothyroidism.
[7] The use of natural therapies to treat hypertension.
[8] How to recover from cancer.
[9] What causes enlargement and cancer of the prostate gland?
[10] How to enlarge your brain and improve brain function.
[11] Are dental amalgams safe?
[12] What health problem causes arteriosclerosis, Type 2 Diabetes and Cancer?
[13] Use of cesium chloride to cure malignancies.
[14] Current concepts about prolonging life.
[15] Does aspirin prevent heart attacks and strokes?
[16] How do intestinal bacteria influence brain function?
[17] The overlooked relationship between infectious diseases and mental symptoms.
[18] How to decrease your risk of heart attack by 70%.
[19] Would you like to cure colds in two hours and influenza in three hours?
[20] What causes gall bladder pain and how to avoid surgery.
[21] Solved the riddle of eclampsia (toxemia of pregnancy) and birth defects in the newborn.
[22] The health hazards of blocking acid production by the stomach.
Editor (New Jersey, United States)
Paul G. King, PhD, MS
Dr. King is an analytical chemist (Ph.D.) and an inorganic chemist (MS) as well as a systems analyst and quality systems professional. His expertise covers the discovery, characterization, development, analysis and manufacture of research chemicals, biocides, drugs, and dietary supplements as well as the quality systems fundamentals and require-ments appertaining thereto. He has more than 25 years of accomplishment in analytical research and design develop-ment, laboratory and management, process development and validation, quality systems implementation, and innovation. He has more than 30 publications and articles that have provided a significant contribution to the fields they concern. Further, he has provided formal written and oral testimony to Congress, the Institute of Medicine, and the US Food and Drug Administration in areas that directly affect public health and safety and/or bear on current good manufacturing practice (CGMP) for drugs, dietary substances, and devices. Currently, his focus is the public health and safety issues associated with: a) drugs and devices that contain mercury-based compounds, b) systematic knowing non-compliance with CGMP, and c) our current treatment-centric healthcare system.
In 1969, Dr. King was awarded an MS in Inorganic Chemistry by Emory University, Atlanta, Georgia that included the following subjects of study, inorganic chemistry, organic chemistry, physical chemistry, and analytical chemistry. His thesis presented his research on “The Coordination Chemistry of Tantalum (V).”
From mid-1969 to mid-1971, Dr. King served in the Army Medical Corps as a Physical Science Assistant (MOS: 01F20). During his short active service he rose to the rank of Specialist 5 and won the Serviceman of the Quarter Awards for both Walter Reed General Hospital and the Walter Reed Army Medical Center. He received an Honorable Discharge and was awarded a Good Conduct medal.
In 1974, Dr. King was awarded a Ph.D. in Analytical Chemistry from the Emory University in Atlanta Georgia which included the following subjects of study: analytical chemistry, physical chemistry, inorganic chemistry, clinical chemistry, and statistics. His dissertation, “The Automated Development of Analytical Methods,” won a Sigma Xi award for scientific excellence.
From late-1974 through 1975, Dr. King worked at The University of Georgia in Athens, Georgia as a Graham Perdue Postdoctoral Fellow and Assistant Professor to Dr. L. B. (Buck) Rogers, Graham Perdue Professor. There he was, among other things, the System Manager, Systems Analyst, and Programmer for a Multi-User Hewlett Packard Minicomputer. Research efforts included the design and the construction of a computer-controlled system for constant-temperature (± 0.01°C) comparative study of enzymatic reaction rates of immobilized enzymes to the rates using the soluble enzyme.
From 1976 through mid-1981, Dr. King worked for American Cyanamid, West Windsor, NJ in Analytical Research and Development. During his tenure there, he:
· Developed analytical methods and techniques.
· Discovered and developed a low-ppb impurity method for the analysis of N-nitroso-amine impurities in chemical compounds.
· Led team that redeveloped the process and analytical controls for the manufacture of a nitrated herbicide active.
· Supervised the successful overhaul of Puerto Rican laboratory operations for a facility that manufactured the drug LEVAMISOL.
· Developed a modernized, solution-density-based Phase Solubility methodology.
From mid-1981 through mid-1983, Dr. King worked for BASF in Fairfield, NJ as a Senior Research Scientist. While there, he:
· Spearheaded International BASF Corporate Team that selected the Laboratory Information Management System (LIMS) vendor to be used by BASF worldwide.
· Led the successful worldwide round-robin inter-laboratory validation of a key analytical method that he had developed.
· Led the Analytical Method Team that developed innovative sampling and test methods.
· Developed method for manufacturing “acetamide” HPLC columns.
From late-1983 through mid-1984, Dr. King worked for Berlex Laboratories, a subsidiary of Schering Ag in Cedar Knolls, NJ as a Senior Scientist. During his short time there, he:
· Led a reorganization of the laboratory that increased its productivity and raised its stature.
· Developed and improved analytical methods.
· Developed improved operational protocols and test procedures.
· Found novel HPLC separation approaches for chiral compounds and chiral mixtures.
From late-1984 through mid-1985 when the firm ceased operations, Dr. King worked for At-Sea Incineration, Parsippany, NJ as Manager of Laboratory Operations. While he was there, he:
· Oversaw all aspects of both the company’s laboratory operations and the activities of the contract laboratories that performed testing for the company.
· Developed sampling-system designs for a high-temper-ature shipboard incinerator.
From 1986 through early-1991, Dr. King worked for Biocraft Laboratories (now part of Teva), in Waldwick, NJ for 0.5 year as Manager of the Quality Control laboratory and about 6 years as Director of Laboratory Quality Assurance in Elmwood Park, NJ. During his tenure there, he:
· Managed a Bulk Pharmaceutical Chemical Quality Laboratory.
· Developed improved HPLC, GC, and titrimetric methods for ingredient testing.
· Directed the auditing of the Drug-Product Laboratory
· Implemented a validated “clonable” LIMS system.
· Developed and validated stability-indicating methods and cleaning methods.
· Developed and validated an FDA-accepted sub-ppm HPLC method for detecting possible penicillin contamination.
· Traveled to China and, while there, developed a process, and controls, for the manufacture of the drug Sucralfate.
· Ascertained the solid-state structure of Sucralfate using solid-state NMR; and oversaw the writing and submission of a Type II Drug Master File for this drug.
From 1991 through late-1994, Dr. King worked for Sidmak Laboratories (now Pliva), East Hanover, NJ as their Director of Quality Control. While he was there, he:
· Took charge of the development and validation of methods; reorganized operations; restructured lab audit and control procedures; and upgraded SOPs, training and staff so that operations conformed to the quality systems expectations of ISO Guide 25 (now, ISO 17025).
· Designed, equipped, and staffed two new laboratories.
· Implemented systems for: acquisition, evaluation and archival of all data; qualification of instruments and analysts; demonstration of analyst/equipment “suitability;” and critical evaluation of results.
During 1995, Dr. King worked for Nutro Laboratories (now, a NTBY subsidiary), South Plainfield, NJ as Director of Quality. While he was there, he:
· Improved product quality by starting the critical checking of data and effecting production changes.
· Furnished the President of Nutro with detailed information on quality problems, their root causes and changes that could either eliminate the problem or reduce the risk of a recurrence.
From 1996 early 2000, Dr. King headed Paul G. King Consulting, Lake Hiawatha, NJ. During that period, he:
· Worked with a variety of clients to solve their problems, develop and validate test methods and procedures, design robust processes, and improve their quality.
· Audited proposals, systems, and suppliers as well as generated documents, methods, designs and systems as needed.
From early 2000 through early-2001, Dr. King worked for R & D Scientific Corporation, Flanders, NJ as their VP of Quality management. During his short tenure there, he:
· Spearheaded the conversion of manufacturing systems from ad hoc into documented systems that complied with the strictures of ISO 9001:1994.
· Generated requisite policy, SOP, work instruction and tool documents for quality management and related functions.
· Provided guidance to the other personnel.
· Rewrote the Users Manual for their main product to match that system’s functionalities.
From 2001 to the present, Dr. King heads Facility Automation Management Engineering (FAME) Systems, Lake Hiawatha, NJ. During this period, he has been working with clients, including the US Food and Drug Administration (FDA) and public advocacy groups, to:
· Provide training in, insight into, and analysis of the requirements of the drug CGMP statutes and regulations as well as their impacts and cost effective approaches to pro-active quality-based systems for compliance with said requirements. [Note: Areas addressed include method/process development, validation, and manufacturing, and Electronic Records.]
· Address public health and safety issues associated with current industry practices, FDA guidances and initiatives, and the CDC’s handling of the “mercury in medicines” issues.
Dr. King is currently a member of the American Chemical Society (ACS), the American Society for Quality (ASQ), the ISPE, and the PDA.
Dr. King has spent the last thirty plus years in the pursuit of knowledge. His works, writings and teachings strive to make the scientific community aware of the real purpose of its work, understanding. To further the dissemination of this understanding, he has written more than sixty white papers and published parts of some of them.
As a scientist, Dr. King understands that he must accept, as possibly true, any hypothesis, no matter how much it differs from “conventional wisdom,” until it is proven to be fatally flawed.
In addition, he accepts the validity of “Ockham’s razor” – which, in his view, is the simplest scientific explanation, no matter how “unconventional” at the time it is proposed, is often the one that proves to be most valid.
Finally, unlike many with whom he interacts in the government, industry and academia, he truly understands that a high-confidence-level (≥ 95%), population-representative sample must be tested before any valid statistics-based decision can be made about the probable nature of that population.
A more-detailed presentation of Dr. King’s credentials, including a list of his publications, white papers and other formal documents, is available through his web site http://dr-king.com.
Editor (Illinois, United States)
Andrew Maniotis, PhD
Dr. Andrew Maniotis is Program Director in the Cell and Developmental Biology of Cancer, Department of Pathology, Anatomy and Cell Biology, and Bioengineering in the College of Medicine Research Building at the University of Illinois at Chicago.
Pre-Graduate Education and Research
1980-1983 A. B., Physical anthropology. Laboratory focus: human osteology. Professors Stephen Molnar, Robert Sussman, directors. Department of Anthropology, Washington University, St. Louis, MO.
1983-1985 Research Technician, Laboratory focus: neuroexitotoxicity, and developmental neurobiolgy. Dr. John Olney, and Dr. Richard Bunge, directors. McDonnell Center for Higher Brain Function, Departments of Psychiatry, Anatomy Cell Biology, Washington University School of Medicine, St. Louis, MO.
1985-1986 Research Technician, Laboratory focus: muscle development. Professor Richard Strohman, director. Department of Zoology, University of California, Berkeley CA.
1986-1991 Ph.D., Cell biology, Laboratory of cytoskeletal biology. Professor Manfred Schliwa, director and graduate advisor. Departments of Zoology, Cell and Molecular Biology, University of California, Berkeley, CA.
1991-1992 NIH-Post-Doctoral Fellow in Cell Biology, Cell Biology Group, Dr. Thoru Pederson, director. Worcester Foundation for Experimental Biology, Shrewsbury, MA.
1992-1997 Fellow in Surgical Research, Laboratory of tumor angiogenesis, Dr. Donald Ingber, Post-Doctoral Advisor, Dr. Judah Folkman, director. Department of Surgical Research and Pathology, Harvard Medical School, Boston, MA.
1992-1997 Fellow in surgical Research. Laboratory of tumor angiogenesis. Dr. Donald Ingber, Post-Doctoral Advisor, Dr. Judah Folkman, director. Department of Surgical Research and Pathology, Harvard Medical School, Boston, MA.
1997-2000 Research Scientist, Department of Anatomy and Cell Biology, and the Iowa Cancer Center, University of Iowa, Iowa City, IA.
2000-2006 Assistant Professor of Pathology, Anatomy and Cell Biology, and Adjunct Prof. of Bioengineering. Director of the Program of The Cell and Developmental Biology of Cancer, University of Illinois, Chicago, Chicago IL. 60612.
1988 Stipend for Evolutionary studies, Museum of Vertebrate Zoology, University of California, Berkeley, CA. 1990.
1992 USDA Fellowship in the Molecular Biology of Insect Viruses, Department of Entomological Sciences, University of California, Berkeley, CA.
1994 Zum Thema Wissensbank Honorarium.
1995 Invited speaker, Gordon Confererence on “The Biological Basis of Cell and Tissue Structure and Function,” Copper Mountain, CO.
1997 Work presented by “The Second Annual Videoconference On Space Station Research,” NASA.
1997 Work presented by The Faraday Society.
1998 Work presented by “The Penrose-Hameroff Colloquium.”
1998 Work cited by The Royal Society, London. 1998.
1999 Invited Lectureship: Biological Physics Colloquium, Banff, Canada.
2000 Research Colloquium Lectureship on Integrins, Madison, WI.
2000 Earnest Orlando Lawrence Berkeley National Laboratory Lectureship, Berkeley, CA.
2001 Physicochemical processes in biological systems in space overstudy panel report.
2002 Nomination for Bodossaki Foundation Award, Athens, Greece.
2003 Who's who in American Science; 2003-2005.
2003 Invited Speaker: Gordon Conference on Polyamines, New London, CT.
2003 Invited Speaker: FASEB conference on Chromatin Structure and Cancer, Saxon Rivers, VT.
2005 Lectureship Colloquium on Polyamines, Cellgate, Pharmaceuticals, Redwood City, CA.
2005 First and second place winner, Health and Medicine Engineering, UIC., Chicago, IL.
2006 TREC Accelerator Award Recipient on Viral Assays, National Center for Supercomputing Applications, Champaign-Urbana, IL.
Other Activities: Invited Member of The Boston Vascular Task Force, Children's hospital, Boston MA. 1995-1997, Judah Folkman, director.
Study section(s): Ad Hoc Grant Reviewer: “Therapeutic Modulation of Angiogenesis in Disease.” NCI, 1998-9. Invited member: “APA, Screening Technologies Branch DTP, DCTD, NCI.” Fall 2000.
Reviewer: American Journal of Physiology, Journal of Cellular Biochemistry, FACEB Journal, American Journal of Pathology, British Medical Journal, and others.
Research Program and Goals: Melanoma and breast cancer therapeutics; vaccine adjuvants and cancer; tensegrity modeling; biochemical reconstruction of chromosomes; see mechanogenomics.com.
[1] Clifford DB, Olney JW, Maniotis A, Collins RC, Zorumski CF. The functional anatomy and pathology of Lithium-Pilocarpine and high dose pilocarpine seizures. Neuroscience 1987;23(3):953–68.
[2] Strohman RC, Bayne E, Spector D, ObinataT, Micou-Eastwood J, Maniotis A. Myogenesis and histogenesis of skeletal muscle on flexible membranes. In Vitro Cell Dev. Biology 1990;26:201–8.
[3] Maniotis A, Schliwa M. Microsurgical removal of centrosomes blocks cellular reproduction and centrosome regeneration in BSC-1 cells. Cell 1991 Nov. 1;67(3):495–504.
[4] Schutze, K., Maniotis, A., Schliwa, M. The position of the microtubule-organizing center in directionally migrating fibroblasts depends on the nature of the substratum. Proc. Nat. Acad. Sci. 1991;88:8367–71.
[5] Maniotis A, Chen C, Ingber D. Demonstration of mechanical interconnections between integrins, cytoskeletal filaments, and nuclear scaffolds that stabilize nuclear structure. Proc. Nat. Acad. Sci . 1997;94:849–54.
[6] Maniotis A, Bojanowski K, Ingber D. Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells. J. Cellular Biochem. 1997;65:114–30.
[7] Bojanowski K, Maniotis A, Ingber D. DNA toposiomerase ll can control chromatin topology and drive chromosome condensation without enzymatically modifying DNA. J. Cellular Biochem. 1998;69:127–42.
[8] Eckes B, Dogic D, Colucci-Guyon E, Wang N, Maniotis A, Ingber D, Merckling A, Aumailley M, Delouvee M, Koteliansky V, Babinet C, Krieg T. Impaired mechanical stability, migration, and contractile capacity in vimentin-deficient fibroblasts. J. Cell Science 1998;111:1897–907.
[9] Eckes B, Martin P, Smola H, Dogic D, Colucci-Guyon E, Maniotis A, Wang N, Aumailley M, Ingber D, Babinet C, Krieg T. Disruption of tensegrity in vimentin-deficient fibroblasts causes delayed wound healing in fetal and adult mice. J. of Dermatol. Sci. 1998 March;16(1001):120.
[10] Pourati J, Maniotis A, Spiegel D, Schaffer JL, Butler JP, Fredberg JJ, Ingber DE, Stamenovic D, Wang N. Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells? Am. J. Physiol. 1998 May; 274 (5 Pt 1):C1283–9.
[11] Maniotis A, Folberg R, Hess A, Seftor E, Gardner L, Pe’er J, Trent J, Meltzer P, Hendrix M. Vascular channel formation by human uveal melanoma cells in vivo and in vitro: Vasculogenic mimicry. Amer. J. Path. 1999 Sept.;I55(3):739–52.
[12] Verdolini K, Zeitels S, Maniotis A, Desloge R, Hillman R. Role of mechanical stress in tissue recovery subsequent to acute phonotrauma. Speach-Language. Path. 1999 June.
[13] Warso MA, Maniotis A, Chen X, Majumdar D, Patel NK, Shilkaitis A, Gupta TK, Folberg R. Prognostic significance of periodic acid-Schiff-positive patterns in primary cutaneous melanoma. Clin Cancer Res. 2001 Mar;7(3):473-7.
[14] Folberg R, Chen X, Boldt HC, Pe’er J, Brown CK, Woolson RF, Maniotis AJ. Microcirculation patterns other than loops and networks in choroidal and ciliary body melanomas. Ophthalmology 2001;98:996–1001.
[15] Maniotis A, Chen X, Garcia C, DeChristopher PJ, Wu D, Pe’er J, Folberg R. Control of melanoma morphogenesis endothelial survival, and perfusion by extracellular matrix. Lab Investigation 2002;82(8):1083–92.
[16] Mueller A, Maniotis A, Freeman W, Bartsch D, Schaller UC, Bergeron-Lynn G, Cheng L, Taskintuna I, Chen X, Kan-Mitchell J, Folberg R. An orthotopic model for human uveal melanoma in SCID mice. Microvasc Res. 2002 Sept.;64(2):207–13.
[17] Chen X, Maniotis AJ, Majumdar D, Pe'er J, Folberg R. Uveal melanoma cell staining for CD34 and the assessment of tumor vascularity. Invest Ophthalmol Vis Sci. 2002 Aug.; 43(8):2533–9.
[18] Chen X, Ai Z, Rasmussen M, Bajcsy P, Auvil L, Welge M, Leach L, Vangveeravong S, Maniotis AJ, Folberg R. Three-dimensional reconstruction of extravascular matrix patterns and blood vessels in human uveal melanoma tissue: techniques and preliminary findings. Investigative Ophthalmology and Visual Science 2003;44:2834–40.
[19] Seftor EA, Meltzer PS, Kirschmann DA, Pe'er J, Maniotis AJ, Trent JM, Folberg R, Hendrix MJ. Molecular determinants of human uveal melanoma invasion and metastasis. Clin Exp Metastasis 2002;19(3) 233–46.
[20] Maniotis AJ, Valyi-Nagy K, Karavitis J, Moses J, Boddipali V, Wang Y, Nuñez R, Setty S, Arbieva Z, Bissell MJ, Folberg R. Chromatin organization measured by Alu I restriction enzyme changes with malignancy and is regulated by the extracellular matrix and the cytoskeleton. Am J Pathol. 2005 Apr.;166(4):1187–203.
[21] Lin AY, Maniotis AJ, Valyi-Nagy K, Majumdar D, Setty S, Kadkol S, Leach L, Pe'er J, Folberg R. Distinguishing fibrovascular septa from vasculogenic mimicry patterns. Arch Pathol Lab Med. 2005 Jul.;129(7):884–92.
[22] Kadkol SS, Lin AY, Barak V, Kalickman I, Leach L, Valyi-Nagy K, Majumdar D, Setty S, Maniotis AJ, Folberg R, Pe'er J. Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study. Invest Ophthalmol Vis Sci. 2006 Mar.;47(3):802-6.
[23] Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chévez-Barrios P, Larsen P, Majumdar D, Pe’er J, Maniotis AJ. Tumor Cell Plasticity in Uveal Melanoma: Microenvironment Directed Dampening of the Invasive and Metastatic Genotype and Phenotype Accompanies the Generation of Vasculogenic Mimicry Patterns. Accepted, June, 2006, American Journal of Pathology, In press, October issue, 2006.
[24] Ingber D. Dike L, Hansen L, Karp S, Liley H, Maniotis A, McNamee H, Mooney D, Sims J, Wang N. Cellular tensegrity: exploring how mechanical changes in the cytoskeleton regulate cell growth, migration, and tissue pattern during morphogenesis. In: Engineering of the cytoskeleton in developmental biology. 1994;150:173–224.
[25] Goldman WF, Alonso JL, Bojanowski K, Bragwynne C, Chen CS, Chirchurel ME, Dike L, Huang S, Lee KM, Maniotis A, Mannix R, McNamee H, Meyer C, Naruse K, Parker KK, Plopper G, Polte T, Wang N, Yan L, Ingber DE. Cell shape control and mechanical signaling through the cytoskeleton. The Cytoskeleton and Signaling: A Practical Approach. Chapter 11, 1999.
[26] Chen C, Ingber D, Maniotis A.. A strategy for research in space biology and medicine in the new century. Physiology, Gravity, Space, Chapter 6, 1998.
[27] Folberg R, Hendrix M, Maniotis A. Vasculogenic mimicry and tumor angiogenesis. Am. J. Pathol. 2000 Feb.; [Review] 156(2):361–81.
[28] Folberg R, Pe’er J, Maniotis AJ. Extravascular matrix patterns in uveal melanoma: histogenesis, structure, and molecular regulation. In: Uveal Melanoma: A model for Exploring Fundamental Cancer Biology. Swets & Zeitlinger, Publishers, 2004.
[29] Gordon R, Karavitis J, Moses J, Valyi-Nagy K, Maniotis A. Differentiation waves versus positional information of morphogen gradients: which is cause and effect? Fifth International Workshop on Information Processing in Cells and Tissues, September 8 - 11, 2003 Lausanne, Switzerland.
[30] Papadopulos-Eleopulos E, Turner VF, Papadimitriou J, Page B, Causer D, Alfonso H, Mhlongo S, Miller T, Maniotis A, Fiala C. A critique of the Montagnier evidence for the HIV/AIDS hypothesis. Med Hypotheses. 2004; 63(4):597–601.
[31] Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chevez-Barrios P, Larsen P, Majumdar D, Pe’er J, Maniotis AJ. Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. Am J Pathol., 2006 Oct.;169(4):1376–89.
[32] Folberg R, Maniotis A. Vasculogenic mimicry. Acta Pathologica Microbiologica et Immunologica Scandinavica, 2004;112:508–25.
[33] Guzman G, Cotler SJ, Lin AY, Folberg R, Maniotis AJ. Expression of vasculogenic mimicry correlates with earlier hepatocellular carcinoma recurrence after orthotopic liver transplant. Submitted.
[34] Sandal T, Folberg R, Maniotis A. Targeting the extracellular matrix tumor biofilm: disrupting tumor organization by antibodies to the matrix assembly domains of fibronectin, is accompanied by tumor cell death. Submitted.
[35] Sandal T, Valyi-Nagy K, Hayee A, Marton LJ, Maniotis AJ. Sensitivity of metastatic cells to polyamine analogs depends upon DNA sequestration and phenotype. Submitted.
[36] Sandal T, Valyi-Nagy K, Folberg R, Bissell M, Spensor V, Maniotis A. Epigenetic reversion of breast carcinoma phenotype and DNA sequestration. Submitted.
[37] Valyi-Nagy K, Folberg R, Valyi-Nagy T, Maniotis AJ. Susceptibility of herpes simplex virus type I and II, the role of tumor invasiveness, the extracellular matrix, and chromatin suestration. Submitted.
Some expert critiques of primary work
Work on centrosomes and cellular microsurgury:
· Nature, 1992, 355:300–1. “Centrosome and Cell Division.”
· Current Opinions in Cell Biology, 1992; 2(5):243–5. “Double or Nothing.”
Work on cytoskeletal mechanics, tensegrity, and genomics:
· Science, 1997, 276:678–9; “Force-Carrying Web Pervades Living Cell.”
· Annu. Rev. of Physiol., 1997, 59:575–99. “Tensegrity: The Architectural Basis of Cellular Signal Transduction.”
· Scientific American, January, 1998, pp48-57, “The Architecure of Life.”
· Biochem. Cell Biol., 2001, 79:267–74. “The integration of tissue structure and nuclear function.”
Work on cancer:
· Science, September 3rd, 1999. “New type of blood vessel found in tumors.” p1475.
· The Lancet, Sept. 13, 1999. “Tumors find another way to feed themselves.” p2.
· Amer. J. Path., September, 1999, “Tumor plasticity allows vasculogenic mimicry, a novel form of angiogenic switch.” pps. 675-679.
· Focus, Number 38, 20 September, 1999. Nahung fur den Krebs. Cover story.
· Chicago Tribune, September 17, 1999. “Cancer Theory is Questioned.” Front page.
· College of American Pathologists, 2000. “Eyeing a new path for tumor growth.” Feature story.
· New Scientist: 11 Sept, 1999. “Organized Killers,” p11.
· Science, Vol. 287, 4 Feb. 2000. “Face-off over tumor blood supply,” pps. 783-4.
· Nature Medicine, Volume 6 Number 4 April 2000. “Mechanisms of angiogenesis and arteriogenesis”, p. 392.
· The Lancet Oncology Vol 3 January 2002. Melanoma–stroma interactions: structural and functional aspects. p35-43.
· Basic Pathology, W B Saunders Co. Current 2004 Edition. In: Neoplasia; “Vasculogenic mimicry in Uveal melanomas.” V Kumar, R S Cotran and S L Robbins.
· Am J Pathol. 2005 Apr;166(4):959-62. Review. Mechanogenomic control of DNA exposure and sequestration. Stein GS.
· DNA 'Packaging' Linked with Cancer; National Review of Medicine (Canada). May 15, 2005,Vol. 2, No. 9. “Protein markers flag cancer cells that are impervious to chemo.”
Current Grant Support
Project title: “Microcirculation of Uveal Melanoma”
Source: NIH RO1 10457-07
Sponsoring Institution UIC.
Dates of project: 1/01/97--12/31/06.
Total direct costs: $800,274
Role: Co-P.I. 50% Effort. Active.
Project title: “The Rapid Infectivity and Lysis Assay (RILA)”
Source: Navy
Sponsoring Institution: UIC
Dates of project: Aug. 2006-March 2006
Total direct costs: $70,000
Role: P.I. 10% effort. Active.
Project title: “The action of polyamine analogs”
Source: Cellgate Pharmaceuticals.
Dates of project: 6/2006-12/2006
Total Direct Costs $30,000
Role: P.I. 5% effort. Active.
Past Grant Support
Project title: “Determinants of Lung Parenchymal Function”
Source: NIH-Consortium Grant. PO1 HL33009-11
Sponsoring Institution: Harvard Medical School
Dates of project: 1998-2000.
Total direct costs: $6,957,825 over 5 years.
Role: Project co-investigator. Completed.
Project title: “Novel Inhibitors of Angiogenesis and Tumor Vasculogenesis”
Source: NCI. R21 CA83137-01
Sponsoring Institution University of Iowa.
Dates of project: 7/01/99--11/30/2001. Extended to August 2002.
Total direct costs: $193,256 over 2 years.
Role: P.I. Completed.
Project title: “Regulation of Uveal Melanoma Interconverted phenotype”
Source: NCI. RO1-CA 80318-01
Sponsoring Institution: University of Iowa
Dates of project: Began December 1998-2003.
Total direct costs: $993,000 over 5 years.
Role: Co-principal investigator. Completed.
Project title: “Controlling The Organization Of The Breast Cancer Cell Genome With Extracellular Matrix”
Source: DOE subcontract.
Sponsoring Institution: UIC, Lawrence Berkeley Laboratories, Mina Bissell, P.I.
Dates of project: 1/2003-2/2005
Total Direct Costs $230,000
Role: P.I. 35% effort. Completed.
Inventions
· Quantitative chromosome stability assay.
· Cytoplast morphogenesis assay.
· Three-dimensional gene sequestration and expression assay.
· Rapid Infectivity and lysis assay (RILA).
· Tumor reversion assay.
Teaching Experience
· Spring, 1983. Instructor: “Osteology”. Department of Anthropology, Washington University, St. Louis, MO.
· Fall, 1986, Spring, 1987. Instructor: “Biology 1A, 1B”. Department of Zoology, University of California, Berkeley, CA.
· Fall, 1988, Lecturer: “Cytogenetics" 110, Department of Zoology, University of California, Berkeley CA.
· Spring, 1989.Lecturer: "Cytogenetics Laboratory”. Department of Zoology, University of California, Berkeley CA.
· Fall, 1989. Instructor, “Molecular Cell Biology”. Department of Molecular Biology, University of California, Berkeley CA.
· Spring, 1990. Course Coordinator and Instructor: “Molecular Cell Biology 130”. Department of Molecular Cell Biology, University of California, Berkeley, CA.
· May, 1991. Instructor: “Advanced Quantitative Light Microscopy”. Woods Hole, MA.
· Fall 1997-8. Research Scientist. “Cell Biology”, graduate course. Department of Biochemistry. University of Iowa Medical College, Iowa City, IA.
· Fall 2000. Assistant Professor of Pathology. Bioengineering 1A. Department of Bioengineering, University of Illinois, Chicago, Chicago, IL.
· Spring, 2000. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.
· Fall 2001. Assistant Professor of Pathology. “Pathology for 2nd Year Medical students”. Department of Pathology. University of Illinois, Chicago, Chicago IL.
· Fall 2001. Assistant Professor of Pathology. “Graduate Course in Microbiology”. Department of Microbiology. University of Illinois, Chicago, Chicago, IL.
· Spring, 2002. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.
· Fall, 2002. Assistant Professor of Pathology. “Pathology for 2nd Year Medical Students. Department of Pathology, University of Illinois, Chicago, IL.
· Spring, 2003. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.
· Fall, 2004. Assistant Professor of Bioengineering. Senior Design Course. Department of Bioengineering, University of Illinois, Chicago, Chicago IL.
· Spring, 2004. Assistant Professor of Bioengineering. Senior Design Course. Department of Bioengineering, University of Illinois, Chicago, Chicago IL.
Undergraduate Students in the lab
2002-2003. Ms. Ying Wang. Synkaryon construction project as a test for the effect of matrix on microenvironmoental subzones.
2001-2003. Mr. Christopher Garcia. Developed an enucleated cell model as a test for the effect of matrix on cells lacking nuclei.
2004-2005. Bioengineering Senior Design Course, Bio E, 398.
Team 1 “Matrix Chip” group: Monika Kaniszewska, Anne Styka, Amy Peters.
Team 2 “Oncogel” group: Tiffany Moy, Priyamvada Nagar, Qian Sun.
Team 3. “Cancer Hyperthermia” group: Bob Trombley, Mateusz Zagata, Rana Deeb.
Teams 1, 2 won 1st and 2nd place awards in the UIC Health and Medicine Engineering Expo, 2005, April 12, 2005, Student Center East for the design and construction of a “Three-dimensional matrix chip for cancer diagnostics (Monika Kaniszewska, Anne Styka, Amy Peters), and for a “Constricting gel assay and therapeutic patch.” See: http://www.uic.edu/depts /enga/current_students/expo2005.htm.
2006. Bioengineering Senior Design Course, Bio E, 398. A mechanical model of gene control elements: Wajeeha Mahmood, Ravi Patel, Rishi Patel, Mariam Shafiq.
Graduate student courses and seminars at UIC
· Cell biology of normal and tumor-cell mechanics during normal morphogenesis and deregulation.
· Multiple mechanisms of tissue and molecular mimicry are exhibited by aggressive cancers and constitute a ground state of cellular and genomic deregulation.
· Cancer, AIDS,. And AIDS-related Cancers.
· Cytoplasmic imprinting during morphogenesis.
· The nucleus as a discrete state structural processor of developmental signaling.
· Role of interchromosomal sequences in genomic organization and signal processing.
· Application of specific immunomarkers, computed tomography, and atomic force microscopy in the determination of the specific order of chromosomes.
· Topological reconstruction of the malignant melanomas.
· Living cells are organized in a manner that reflects the organizational and mechanical principles of tensional integrity (tensegrity).
Editor (California, United States)
W. John Martin, MD, PhD
W. John Martin, MD, PhD, founded “The Center for Complex Infectious Diseases” for investigators to pursue independent studies on the role of viral infection in neuro-psychiatric illnesses. He was born in Australia where he obtained M.B. B.S. (M.D. equivalent) and PhD degrees from the Universities of Sydney and Melbourne, respectively. He had his initial clinical training in Sydney, Australia, and subsequently pursued a pathology residency in the U.S., at the National Naval Medical Command, Bethesda, MD. He has also trained in research in distinguished institutions in Australia, US and Europe, including the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia; Harvard University, Cambridge, MA; National Institutes of Health, Bethesda, MD; and University College, London, England. From 1975-1980, he worked on vaccine safety within the US Food and Drug Administration (FDA). Dr. Martin holds Board Certifications in both Anatomic and Clinical Pathology with subspecialty Board Certifications in Medical Microbiology and in Immuno-pathology.
Dr. Martin has served on numerous national committees for NIH, FDA, Agency for International Development, American Cancer Society, American Society for Clinical Pathology and the College of American Pathologists (CAP). He was the Founding Director of the CAP Molecular Pathology Practicum, an intensive two-week hands-on training program for practicing pathologists. He joined the University of Southern California School of Medicine in 1985 as a tenured Professor of Pathology, a position from which he took leave in 1996. Dr. Martin’s clinical appointments have included Chief of Immunology/Immunopathology Unit, Section of Laboratories and Pathology, Los Angeles County + University of Southern California Medical Center. Under his direction, the Unit was expanded to become the Immunology/Molecular Pathology Unit. Dr. Martin also served as Medical Director of USC Infectious Disease Laboratory and of USC Molecular Pathology Laboratory within the USC Clinical Laboratories, USC School of Medicine. Dr. Martin has lectured widely at both national and international medical conferences and has frequently addressed patients’ support groups. He has published over 100 research articles, many of which have ushered in new concepts in medical science. Dr. Martin enjoys re-searching for the wisdom and knowledge of prior generations. As a pathologist he is in full agreement with the opinion of Alphonse Bertollin (1853-1914) “One can only see what one observes, one observes only the things that are already in the mind.” Dr. Martin also follows the precept of Teihard de Chardin (1881-1914) “The more I look, the more I see, and the more I see, the more I look for.”
Dr. Martin has identified cell damaging (cytopathic) viruses, for which he coined the term “stealth viruses,” in patients with various neuropsychiatric illnesses, including autism, and attention deficit in children, chronic fatigue and depression in adults and dementia in the elderly. The viruses are distinguishable from conventional viruses in that they are lacking the viral components that are normally targeted by the cellular immune system. Consequently, these viruses are not effectively recognized by the immune system and do not provoke an inflammatory reaction in infected individuals. Some of these stealth-adapted viruses were originally derived from the cytomegalovirus present in monkeys used to produce live polio viral vaccines. Stealth viruses can be directly infectious between humans and even between humans and domestic pets.
Even though the cellular immune system does not provide effective protection against stealth viruses, humans and animals can counter the cytopathic effects of these viruses through the formation of alternative cellular energy pigments (ACE-pigments). Dr. Martin initially recognized these pigments in the brain of stealth virus infected individuals and in stealth virus cultures. Various natural products have been identified as having ACE-pigment-like activities and are currently being tested clinically in stealth virus infected patients. Dr. Martin participates in S3Support, a public charity for scientific, social and spiritual support of stealth virus infected individuals (www.s3support.com).
Selected Bibliography
[1] Martin WJ. Detection of viral related sequences in CFS patients using the polymerase chain reaction. In: “The Clinical and Scientific Basis of Myalgic Encephalomyelitis Chronic Fatigue Syndrome.” Byron M. Hyde, Ed. Nightingdale Research Foundation Press. Ottawa Canada 1992;278–83.
[2] Martin WJ. Viral infection in CFS patients. In: “The Clinical and Scientific Basis of Myalgic Encephalomyelitis Chronic Fatigue Syndrome.” Byron M. Hyde, ed. Nightingdale Research Foundation Press. Ottawa Canada 1992;325–7.
[3] Martin WJ. Stealth viruses as neuropathogens. CAP Today, 1994;8:67–7.
[4] Martin WJ, Zeng LC, Ahmed K, Roy M. Cytomegalovirus related sequences in an atypical cytopathic virus repeatedly isolated from a patient with the chronic fatigue syndrome. Am J Path, 1994; 145:441–52.
[5] Martin WJ. Stealth virus isolated from an autistic child. J. Aut Dev Dis, 1995;25:223–4.
[6] Martin WJ, Ahmed KN, Zeng LC, Olsen JC, Seward JG, Seehrai JS. African green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome. Clin Diag Virol. 2005;4:93–103.
[7] Martin WJ, Glass RT. Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome. Pathobiology, 1995;63:115–8.
[8] Gollard RP, Mayr A, Rice DA, Martin WJ. Herpesvirus related sequences in salivary gland tumors. J Exp Clin Can Res, 1996;15:1–4.
[9] Martin WJ. Genetic instability and fragmentation of a stealth viral genome. Pathobiology, 1996;64:9–17.
[10] Martin WJ. Severe stealth virus encephalopathy following chronic fatigue syndrome like illness: Clinical and histopathological features. Patho-biology, 1996;64:1–8.
[11] Martin WJ. Stealth viral encephalopathy: Report of a fatal case complicated by cerebral vasculitis. Pathobiology, 1996;64:59–63.
[12] Martin WJ. Simian cytomegalovirus related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy. Pathobiology, 1996;64:64–6.
[13] Martin WJ, Anderson D: Stealth virus epidemic in the Mohave Valley. Initial report of viral isolation. Pathobiology, 1997;65:51–6.
[14] Martin WJ. Cellular sequences in stealth viruses. Pathobiology, 1998; 66:53–8.
[15] Martin WJ. Bacteria related sequences in a simian cytomegalovirus-derived stealth virus culture. Exp Mol Path, 1999; 66:8–14.
[16] Martin WJ. Stealth adaptation of an African green monkey simian cytomegalovirus. Exp Mol Path, 1999;66:3–7.
[17] Martin WJ. Melanoma Growth stimulatory activity (MGSA/GRO-alpha) chemokine genes incorporated into an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus. Exp Mol Path., 1999; 66:15–8.
[18] Martin WJ, Anderson D. Stealth virus epidemic in the Mohave Valley: Severe vacuolating encephalopathy in a child presenting with a behavioral disorder. Exp Mol Pathol, 1999;66:19–30.
[19] Martin WJ. Chemokine receptor-related sequences in an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus. Exp Mol Path, 2000;69:10–6.
[20] Martin WJ. Stealth viruses. Explore for the Professional, 2001;10(4):17–22.
[21] Martin WJ. Chronic fatigue syndrome among physicians: A potential result of occupational exposure to stealth viruses. Explore for the Professional, 2001;10(5):7–10.
[22] Martin WJ. Chemokines and stealth viruses. A blueprint for therapy in infected individuals. Explore for the Professional, 2002;11(1):7–12.
[23] Martin WJ. Complex intracellular inclusions in the brain of a child with a stealth virus encephalopathy. Exp Mol Path, 2003;74:179-209.
[24] Stealth Virus Culture Pigments: A Potential Source of Cellular Energy. Exp Mol Path, 2003;74:210–23.
Editor (Colombia, South America)
Juan Manuel Martínez Méndez, MD
Dr. Juan Manuel Martínez Méndez graduated in 1987 from Pontificia Universidad Javeriana located in Bogotá, Colombia. Although alternative medicine captured his attention prior to entering the University, it was only after he attended a seminar in 1992 that he really began intense research and study of this topic. From July to December 1986 he did his internship at Hospital San Rafael de Duitama. His internship continued from January to June 1987 at Hospital Universitario San Ignacio. He completed one year of Traditional Chinese Medicine that also involved other holistic approaches. Dr. Méndez is a firm proponent of nutrition as a key in dealing with most diseases.
He is a self taught health complimentary practitioner. He began studying Homeopathy approaches in 1994. In 1999 he received a Homeopathic Therapeutics Diploma from the Centre d’Enseignement et Développement de l’ Homéopathie (C.E.D.H.) in Boiron–Balcas, Bogotá, Colombia. His three children were the inspiration for The Post-Vaccinal Syndrome, which he validated in a homeopathic course and then wrote a thesis on the topic at Fundación Instituto Colombiano de Homeopatía Luis G. Páez in 2001. He currently teaches this topic to other medical doctors and veterinarians at this institute.
During a 3-year hiatus from serving as an orthodox medical practitioner, Dr. Méndez devoted his efforts to research activities that led to his works concerning euglycaemia, progesterone sarcode, and the translation works.
Dr. Méndez is a leader in the field of Alternative Medicine and Homeopathic practice and research. He has investigated the treatment of acute and chronic diseases in depth and has been a pioneer in the area of glandular diseases and post vaccinial syndrome. His excellent reputation earned him a full scholarship during 1999 to 2003 to Homoeopathic Online Education, an Internet post graduate course in advanced homeopathy.
After working at various different medical centers from 1989 to 1999, he currently works in an HMO as a general practitioner and does private consultations. He has been a member of the The Science Advisory Board, The Scientist (http://www .science board.net/), Fundación Instituto Colombiano de Homeopatía Luis G. Páez, and National Center for Homeopathy. Alexandria, Virginia.
His personal approach involves four fundamental areas that are complimentary and interdependent, whereby when correcting one, the others follow:
1. Eucapnia, recently described by Professor Buteyko, concerns maintaining of the desirable concentration (6.5%) of CO2 in lung alveoli. This is achieved via Buteyko therapy, a simple education program aimed at reversing chronic hyperventilation that can be an underlying cause of more than 100 illnesses.
2. Eustress, previously described in studies by the late Dr. Selye, concerns not manifesting low or high stress, but the optimum (helped by sports) for healthy living.
3. Eukinetics, described by osteopathy, ortho-binonomy, etc., concerns the proper and desirable structural relation of bones, joints, ligaments which is accomplished through disciplined exercise.
4. Euglycaemia, is the work horse and research shows that an optimal level of glucose around the clock is essential to obviating acute (as well as life-threatening situations like septicemia), chronic, and degenerative conditions.
Translation into Spanish
· General Analysis Du Docteur Cyrus Maxwell Boger
· Traduction, adaptation et commentaires du Docteur Robert Séror, d’Oloron‑Sainte. Adapted and enlarged into Spanish.
· Remèdes Des Saisons, Dr. Robert Seror
· Les Tableaux Lunaires du Dr. C.M. Boger
· Les Mots Clés De La Matière Médicale Homéopathique, Dr. Robert Seror
· Première Et Deuxième Prescriptions. (Tableau synoptique). Dr. Robert Seror
· Répertoire Des Suppressions En Homéopathie Generalities.
· Key notes comparatives Docteur Robert Séror.
Publications
English
[1] The euglycaemic status and infections. A step to real immunity. Homeolinks, The Netherlands, Vol. 15, Winter 2002.
[2] The euglycaemic status and infections. A step to real immunity. Updated and revised, The Townsend Letter for Patients and Doctors, USA, Aug./Sept. 2004.
[3] Progesterone a “mother” key sarcode. The Homeopath, Dec. 2004.
Spanish
[1] Manual de las vitaminas y una alimentación saludable [Manual of vitamins and healthy eating], Dec. 1995.
[2] Antecedentes en medicina complementaria [Antecedents in complementary medicine], Dec. 1995.
[3] Dieta anti-hipoglicemica [Anti-hypoglycemic diet] enlarged and adapted from Dr. John Tintera, MD. Sept. 2003.
[4] Magnesio: El mineral esencial [Magnesium: The essential mineral], Oct. 2003.
[5] La tiroides: El segundo guardián de la salud [The thyroid: The second guardian of health], Sept. 2004.
[6] La suprarrenal. El primer guardián de la salud [The adrenals: The first guardians of health], July 2004.
[7] La gelatina. Un extraordinario suplemento [Gelatin: An extraordinary supplement], Dec. 2004.
Editor (Washington, United States)
Donald W. Miller, Jr., MD
Donald W. Miller was born in Honolulu, Hawaii on August 5, 1940 where his father, a career Navy surgeon, was then stationed. After receiving an A.B. at Dartmouth College and a M.D. degree from Harvard, he did 7 years of post-graduate surgical training, in general and cardiothoracic surgery, at three hospitals in New York City--Roosevelt Hospital (two blocks south of Lincoln Center, for five years) and then at Columbia-Presbyterian Medical Center and Harlem Hospital. Donald Miller served two years active duty in the Navy, as a Lieutenant Commander, USNR (1970-72) stationed at the Naval Hospital, Camp Lejeune, NC.
Residency training completed, he moved to Seattle and joined the faculty of the University of Washington School of Medicine. Dr. Donald Miller was appointed Chief of its Division of Cardiothoracic Surgery in 1978. After a sojourn practicing cardiac surgery at Swedish Medical Center (1980-2002), where he served as Medical Director of the Swedish Heart Institute from 1994 to 1997, he returned (in January 2003) to the University of Washington as a full-time professor of surgery.
Dr. Miller has written two books on heart surgery, The Practice of Coronary Bypass Surgery (1978) and Atlas of Cardiac Surgery (1983). His views on life are shaped from spending a lot of time over the years in the life and death setting of an open heart operating room.
Music is one of his passions. It began at an early age, playing the saxophone. He played in a student jazz band at the age of 12 and in a hard-bop jazz quintet in high school and college . His college group, The Modern Men, performed at two intercollegiate jazz festivals (in the early 1960s)—at Notre Dame and at Georgetown. Over the years, he has been collecting 78 rpm and LP recordings of jazz, opera, and classical music, notably recordings by the great conductors. Dr. Miller has served on the Board of Trustees of the Seattle Opera, was previously on the Board of the Seattle Symphony Orchestra, and is on the Visiting Committee for the School of Music at the University of Washington.
Dr. Donald Miller has maintained a long-standing interest in philosophy, focusing on Arthur Schopenhauer, and read widely on economics, history, science, and Shakespeare. When not in the operating room or doing these things, he enjoys hiking in the mountains of Washington with his wife, Linda (and when he can corral them, his four children).
Faculty Positions
· 1975-1978 Assistant Professor, Surgery, Division of Cardiothoracic Surgery, University of Washington School of Medicine
· 1978-1980 Associate Professor and Chief, Division of Cardiothoracic Surgery, UW School of Medicine
· 1980-2003 Clinical Associate Professor, Surgery, Division of Cardiothoracic Surgery, UW School of Medicine
· 2003-Present Professor, Surgery, Division of Cardiothoracic Surgery, UW School of Medicine
Hospital Positions
· 1994-1997 Medical Director, Swedish Heart Institute, Swedish Medical Center, Seattle, WA
· 1997-2003 Cardiac Surgeon, Swedish Cardiac Surgery, Swedish Medical Center
· 2003-Present Director, Cardiac Surgery, VA Puget Sound Health Care System, Seattle
· 2003-Present Staff Cardiac Surgeon, University of Washington
Medical Center Honors
· 1958 West Point Football Leadership Award. Presented at the Touchdown Club of Washington, D.C. Twenty-third Annual Dinner, by Vice-President Richard Nixon
· 1965 Boylston Society, Harvard Medical School Board Certification
Board Certification
· 1971 American Board of Surgery
· 1975 American Board of Thoracic Surgery Licensure
Licensure
· 1974-Present Washington
Private Practice
· 1974-1975 Seattle Heart Surgery, Inc. P.S.
· 1980-1992 Northwest Cardiac Surgery Associates
· 1992-1997 Miller & Gregg Cardiac Surgery
Professional Society Memberships
· American Association of Thoracic Surgery
· Western Thoracic Surgical Society
· American College of Surgeons
· Seattle Surgical Society
· Doctors for Disaster Preparedness
· Society of Thoracic Surgeons (1975-1998)
· North Pacific Surgical Association (1982-1990)
Other Professional Activities
· Laboratory Research: Investigator (with Dr. F. V. McCann), Invertebrate Intracardiac Electrophysiology, Marine Biological Laboratory; Woods Hole, Massachusetts, summer 1962.
· Member of the Search Committee to appoint a new Chairman of the Department of Medicine, University of Washington School of Medicine, 1979-1980.
· Executive Committee, Swedish Hospital Medical Center, 1985-1988.
· Surgical Council, Swedish Hospital Medical Center, 1989-1992.
· Chief Medical Consulting Officer, preventionZONE, LLC/dba iWellness, 2002-2003.
Books Written
· Miller, D.W., Jr.: The Practice of Coronary Artery Bypass Surgery (243 pages). New York: Plenum Publishing Corp., 1977. ISBN 0-306-31065-1
· Dillard, D.H. and Miller, D.W., Jr.: Atlas of Cardiac Surgery (258 pages). New York: MacMillan Publishing Corp., 1983. ISBN 0-02-329530-9
· Atlas of Cardiac Surgery translated into Japanese and published by Dobin Shoin, Tokyo, 1985.
· Miller, D.W., Jr.: Heart in Hand (251 pages) Xlibris Corp., 1999. ISBN 0-7388-0668-4 (Hardcover), 0-7388-0669-2 (Softcover).
· Book Chapter: Miller, D.W., Jr. and Johnson, D.D.: Coronary Bypass Surgery in the 1980s. In Clinical Essays on the Heart,Volume 2. Hurst, J.W., Editor. New York: McGraw Hill, 1983.
Taped Interview
· Miller DW, Jr. and Likoff W: The Practice of Coronary Artery BypassSurgery in the 1980s. ACCEL. (American College of Cardiology), 13: 4, Side 1, April, 1981.
Community and Cultural Activities (partial list)
· Board of Directors, Seattle Symphony Orchestra, 1983-1987.
· Member of the (six-person) Search Committee to appoint a new Music Director/Conductor, 1984.
· Board of Trustees, Seattle Opera Association, 1984-Present
· Development Advisory Board, College of Arts and Sciences,University of Washington, 1985-1988.
· Board of Trustees, Seattle Chamber Music Festival, 1986 to 1995.
· Visiting Committee, School of Music, College of Arts and Sciences, University of Washington, 1988-Present
· The Diet, City of Seattle, 1995-Present
· Board of Directors, Prepared Response, Inc., 2001-2002.
· Board of Directors, preventionZONE, LLC/dba iWellness, 2002-2003.
Papers Presented (Medically related) at Regional, National, and International Meetings
[1] Lower Esophageal Webs, Annual Meeting, New York Society for Thoracic Surgery; New York, New York, February 15, 1968.
[2] Celiac Artery Aneurysms: Rational for Celiac Axis Ligation with Excisional Treatment, Sixteenth Annual Meeting, American College of Angiology; New York, New York, June 25, 1970.
[3] Angina: Surgical Treatment, Family Practice Refresher Course, King County Academy of Family Physicians; Seattle, Washington, February 2, 1975.
[4] Indications for and Results of Coronary Vein Bypass Surgery, Postgraduate Course, Internal Medicine, University of Washington; Seattle, May 14, 1976.
[5] Current Practice of Coronary Artery Bypass Surgery: Results of a National Survey, Second Annual Meeting, Samson Thoracic Surgical Society; Banff, (Alberta) Canada, June 2, 1976.
[6] Surgical Experience with Bypass Grafts: Overview of a National Experience, Atherosclerotic Heart Disease, 1977, American Heart Association; Victoria, (British Columbia) Canada, July 22, 1977.
[7] Surgical Managment of Coronary Atherosclerosis, Current Concepts and Controversies in Medicine, University of Washington; Seattle, May 5-6, 1978.
[8] Surgical Therapy for Catastrophic Complications of Infarction, Annual Meeting, Pacific Northwest Chapter, American College of Chest Physicians; Seattle, Washington, July 21, 1978.
[9] Medical-Surgical Management of Angina, Grand Rounds, Kennewick General Hospital; Kennewick, Washington, July 3, 1979.
[10] Risks of Coronary Arteriography and Bypass Surgery in Patients with Left Main Coronary Stenosis, VII Asian-Pacific Congress of Cardiology; Bangkok, Thailand, November 25-30, 1979.
[11] Results of a Survey of the Professional Activities of 811 Cardiopulmonary Perfusionists, Seventh Annual Meeting of the Samson Thoracic Surgical Society; Maui, Hawaii, June 26, 1981.
[12] Constructing a Cardiac Surgery Database, Computers in Medicine Symposium: Part I, Swedish Hospital Medical Center; Seattle, Washington, July 8, 1983.
[13] Cardiac Surgery Databases, Computers in Medicine Symposium: Part III, Swedish Hospital Medical Center; Seattle, Washington, September 30, 1983.
[14] Professional Activities of Perfusionists, Pathophysiology & Techniques of Cardiopulmonary Bypass: IV; San Diego, California, March 11, 1984.
[15] Ventricular Septal Defect following Blunt Thoracic and Abdominal Trauma, Annual Scientific Program, Seattle Surgical Society; Seattle, January 16, 1987.
[16] Valve Replacement in the Elderly, Cardiology Update, American Heart Association of Washington; Seattle, October 13-14, 1988.
[17] The UW Model for Risk Stratification, Forum on Risk Stratification of the Cardiac Surgery Patient, University of Washington; Seattle, December 5, 1992
[18] Risk Stratification in the Assessment of Cardiac Surgical Outcome and Cost, Annual Scientific Program, Seattle Surgical Society; Seattle, Washington, January 23, 1993.
[19] The Art and Science of Cardiac Surgery, Festspiel for Dr. David Dillard, University of Washington; Seattle, August 27, 1993.
[20] Risk Stratification In Patients Undergoing Heart Surgery, The Crystal Conference: Cost Effective Cardiology for the Primary Care Physician; Crystal Mountain Resort, March 12, 1994
Publications (Science and Medicine)
Abstracts/Published Discussions
[1] Miller, D.W., Jr., McCann, F.V.: Action Potentials in Single Cells of a Tunicate Heart. Biological Bulletin, 123: 504, 1962.
[2] McCann, F.V., Miller, D.W., Jr.: Intracellular Cardiac Potentials in Limulus during Ganglionic Stimulation. Biological Bulletin, 123: 505, 1962.
[3] Miller, D.W., Jr.: Coronary Artery Bypass Surgery (Reply). Journal of Thoracic and Cardiovascular Surgery, 74: 814, 1977.
[4] Miller, D.W., Jr.: Discussion of Myocardial Preservation during Coronary Bypass Grafting. Thoracic and Cardiovascular Surgery, 75: 177, 1978.
[5] Miller, D.W., Jr.: Discussion of Coronary Artery Bypass with the Internal Mammary Artery. Thoracic and Cardiovascular Surgery, 75: 497, 1978.
[6] Miller, D.W., Jr., Ivey, T.D., Bailey, W.W., Johnson, D.D., Hessel, E.A., II: The Practice of Coronary Bypass Surgery in 1980. Circulation, 62: Supplement III, 95, 1980.
[7] Miller, D.W., Jr., Johnson, D.D., Ivey, T.D.: Does Preservation of Posterior Chordae Tendinea Enhance Survival during Mitral Valve Replacement? Medilex Digest Cardiology, September, 1980.
[8] Miller, D.W., Jr.: Discussion of Translocation. Thoracic and Cardiovascular Surgery, 81: 218, 1981.
Journal Articles (Peer Reviewed)
[1] Miller DW Jr, Wichern WA Jr. Lower Esophageal Rings, Webs, and Annular Strictures. Annals of Thoracic Surgery, 1968;6:401.
[2] Miller, DW Jr., Steward DF, Rosner W. Hypoglycemia Caused by Abdominal Leiomyosarcoma. American Journal Surgery, 1970;119:754.
[3] Miller DW Jr, Royster TS. Celiac Artery Aneurysms: Rationale for Celiac Axis Ligation with Excisional Treatment. Vascular Surgery, 1971;5:42.
[4] Miller DW Jr, Wichern WA Jr. Perforated Sigmoid Diverticulitis: Appraisal of Primary Versus Delayed Resection. American Journal of Surgery, 1971;121:536.
[5] Miller DW Jr, Kelly DL. Splenic Trauma in Children. Archives of Surgery, 1972;105:561.
[6] Relland JYM., Miller DW Jr, and Carberry DM. Traumatic Rupture of the Tracheobronchial Tree. New York State Journal of Medicine, 1973; 73:1291.
[7] Miller DW Jr, Hutchinson JE III, Malm JR. The Nature of Chest Trauma in an Urban Ghetto. New York State Journal of Medicine, 1976;76:1102.
[8] Miller DW Jr, Hessel EA II, Wintersheid LC, Merendino KA, and Dillard DH: Current Practice of Coronary Artery Bypass Surgery. Journal of Thoracic and Cardiovascular Surgery, 1977;73:75.
[9] Miller DW Jr, Dodge HT. The Benefits of Coronary Artery Bypass Surgery. Archives of Internal Medicine, 1977;137:1439.
[10] Miller DW Jr, Bruce RA, Dodge HT: Physiologic Improvement Following Coronary Artery Bypass Surgery. Circulation, 1978;57:831.
[11] Miller DW Jr, Johnson DD, Ivey TD. Does Preservation of the Posterior Chordae Tendeneae Enhance Survival after Mitral Valve Replacement? Annals of Thoracic Surgery, 1979;27:543.
[12] Sands MP, Dillard DH, Hessel EA II, Miller DW Jr. Improved Anesthesia for Deep Surface Induced Hypothermia: The Halothanediethyl Ether Azeotrope. Annals of Thoracic Surgery, 1980;29:123.
[13] Miller DW Jr, Ivey TD. Selection of Patients for Coronary Artery Bypass Operations. Western Journal of Medicine, 1980;133:210.
[14] Hessel EA II, Johnson DD, Ivey TD, Miller DW Jr. Membrane Versus Bubble Oxygenator for Cardiac Operations: A Prospective Randomized Study. Journal of Thoracic and Cardiovascular Surgery, 1980;80:111.
[15] Miller DW Jr, Ivey TD, Bailey WW, Johnson DD, Hessel EA II. The Practice of Coronary Bypass Surgery in 1980. Journal of Thoracic and Cardiovascular Surgery, 1981;81:413.
[16] Miller DW Jr, Tobis F, Ivey TD, Rubenstein SA. Risks of Coronary Arteriography and Bypass Surgery for Left Main Coronary Stenosis. Chest, 1981;79:387.
[17] Breslau PJ, Fell G, Ivey TD, Bailey WW, Miller DW Jr, Strandness DE Jr. Carotid Arterial Disease In Patients Undergoing Coronary Artery Bypass Operations. Journal of Thoracic and Cardiovascular Surgery, 1981; 82:765–67.
[18] Ivey TE, Simonwitz DA, Dillard DH, Miller DW Jr. Boerhaaves Syndrome: Conservative Management in Three Patients with Late Presentation. American Journal of Surgery, 1981;141:531.
[19] Miller DW Jr, Binford JM, Hessel EA II. Results of a Survey of the Professional Activities of 811 Cardiopulmonary Perfusionists. Journal of Thoracic and Cardiovascular Surgery, 1982;83:385.
[20] Bailey WW, Ivey TD, Miller DW Jr. Dacron Patch Closure of Aorticc Annulus Mycotic Aneurysms. Circulation, 1982;66(Supplement I):127.
[21] Ivey MF, Ivey TD, Bailey WW, Williams DB, Hessel EA II, Miller DW Jr. Influence of Propanolol on Supraventricular Tachycardia Early After Coronary Artery Revascularization: A Randomized Trial. Journal of Thoracic and Cardiovascular Surgery, 1983;85:214.
[22] Miller DW Jr., Johnson DD. Omental Pedicle Graft in the Management of Infected Ascending Aortic Prothesis. Annals of Thoracic Surgery, 1987;44:614.
[23] Sparrow JG, Miller DW Jr. Ventricular Septal Defect following Blunt Thoracic and Abdominal Trauma: Case Report. Journal of Trauma, 1989; 29:349.
[24] Bruce R A, Johnson AD, Ivey TD, Miller DW Jr, et al. Relation of Survival After Coronary Artery Bypass Grafting to Functional Adequacy of Surgical Results. Coronary Artery Disease, 1990;1:331.
[25] Eddy AC, Miller DW Jr, Johnson DD, Gartman D, et al. Anterior Sternal Retraction for Reoperative Median Sternotomy. American Journal of Surgery, 1991;161:556.
Editor (Delhi, India)
Santosh Kumar Mittal, MB BS, MD
Dr. S.K. Mittal received his M.B. B.S. and M.D. degrees from A.I.I.M.S. in New Delhi, India in 1967 and 1972, respectively. In 1984 he did fellowship training in pediatric gastroenterology at the Birmingham Children Hospital. Presently, Dr. Mittal is Pediatric Gastroenterologist and Head of the Department of Pediatrics at MAX hospital in New Delhi. Previously he was Director Professor and Head of the Department of Pediatrics at Maulana Azad Medical College, also in New Delhi. Dr. S.K. Mittal has served as a member of the Academic Council of the University of Delhi and Medical Council of India. In 1995 he was President, Delhi Medical Association. He has also served as President of IAP Chapter Pediatric Gastroenterology (Indian Society of Pediatric Gastroenterology & Hepatology). Additional, he has been Convenor of CME, CAPGAN, as well as an executive member of IAP for 4 years, secretary of Delhi Branch IAP (1983), president of Delhi Branch IAP (1989), and a member of the National Immunization Committee (IAP) from 1989 to 1993.
Dr. S.K. Mittal was honored with the F.I.A.P. award in 1986 and received the Delhi State Doctors Award in 1997. In 1986 he established the Pediatric G.I. Endoscopy Unit at M.A.M.C. and the Pediatric G.I. & Hepatology Unit at M.A.M.C. & LN Hospital in New Delhi.
Editorial Experience
§ Chief Editor, Pediatrics Today.(1999-2003)
§ Member, Editorial Advisory Board Ind. J. Pediatrics.
§ Asstt. Editor, Indian Pediatrics (1978-1986).
§ Editor,(Pediatric Section)Tropical Gastroenterology.
Books Written/Edited
§ An approach to Pediatric Problem, 4th Edition.2001
§ Management of Acute & Chronic Diarrhea in children.3rd Edition 2003
§ Immunization in Practice.2nd Edition 1991
§ Early Schooling: Problems & Perpective, 1995.
§ Update in Pediatric Gastroenterology, 1986.
§ Immunization Practices in Children, 2nd Edition 1993
Members of Professional Bodies
§ Indian Academy of Pediatrics
§ Indian Medical Association.
§ Indian Society of Gastroenterology
§ Indian Society of Gastrointestinal Endoscopy.
§ Common Wealth Association of Pediatric Gastro
§ Enterology, Hepatology & Nutriion.(CAPGHAN)
§ I.A.P. Chapter, Pediatric Gastroenterology.
§ American Academy of Prediatrics (Associate Member).
§ I.M.A. Academy of Medical Specialists.
Dr. S.K. Mittal has over 150 peer-reviewed publications to his credit, some of which are given below.
Publications
[1] Mittal SK. Chronic diarrhea in tropics [Review]. Indian J Pediatr, 1999; 66(1 Suppl):S4–15.
[2] Kalra KK, Jain N, Mittal SK. Management of celiac disease [Review]. Indian J Pediatr, 1999;66(1 Suppl):S32–6.
[3] Thakar R, Rath B, Prakash SK, Mittal SK, Talukdar B. Urinary tract infection in infants and young children with diarrhea. Indian Pediatr, 2000 Aug;37(8):886–9.
[4] Mittal SK, Kalra KK, Khanijo CM, Rajeshwari K. Benign oesophageal strictures in children of north India. Trop Gastroenterol., 2000 Jan-Mar;21(1):37–40.
[5] Mittal SK, Aggarwal V, Rastogi A, Saini N. Does B.C.G. vaccination prevent or postpone the occurrence of tuberculous meningitis? Indian J Pediatr, 1996 Sep-Oct;63(5):659–64.
[6] Mittal SK. Pulse Polio Program--a national perspective [Review]. Indian J Pediatr, 1996 Jan-Feb;63(1):1–8.
[7] Dutta AK, Seth A, Goyal PK, Aggarwal V, Mittal SK, Sharma R, Bahl L, Thakur JS, Verma M, Chhatwal J, Chacko B, Saini V, Singhal A, Sharma P, Sharma U, Chaturvedi P, Kumar S, Prajapati NC, Vaidya J, Garg N, Basu SN, Lahiri M, Das CK, Pal DK, Lall SB, et al. Poisoning in children: Indian scenario. Indian J Pediatr, 1998 May-Jun;65(3):365–70.
[8] Mittal SK, Rastogi A. Immunogenecity of hepatitis A vaccine in children below 2 years of age. Indian Pediatr, 1999 Jan;36(1):97.
[9] Maria A, Ramji S, Mittal SK. Prevalence of post partum amenorrhoea and it's relation to infant feeding practices in Indian mothers. J Indian Med Assoc, 1999 Jan;97(1):32.
[10] Rastogi A, Malhotra V, Uppal B, Aggarwal V, Kalra KK, Mittal SK. Aetiology of chronic diarrhoea in tropical children. Trop Gastroenterol, 1999 Jan-Mar;20(1):45–9.
[11] Rajeshwari K, Mittal SK. Post-transfusion chronic liver disease in thalassemics. Trop Gastroenterol, 1998 Oct-Dec;19(4):159–62.
[12] Mittal SK, Rastogi A, Rastogi A, Kumar N, Talukdar B, Kar P. Seroprevalence of hepatitis A in children--implications for hepatitis A vaccine. Trop Gastroenterol, 1998 Jul-Sep;19(3):120–1.
[13] Juneja M, Dubey AP, Kumari S, Prakash C, Mittal SK. Hepatitis B and hepatitis C in multitransfused children. Trop Gastroenterol, 1998 Jan-Mar;19(1):34–6.
[14] Dangwal TR, Aggarwal V, Malhotra V, Baveja U, Mittal SK. Clinical spectrum of chronic liver disease in north Indian children. Trop Gastroenterol, 1997 Oct-Dec;18(4):174–6.
[15] Mittal SK, Panicker J, Kalra KK, Kumar N. Endoscopic diagnosis and treatment of an oesophageal bezoar in a child. Trop Gastroenterol. 1997 Jul-Sep;18(3):125–-6.
[16] Mittal SK, Kalra KK, Khanijo CM, Kumar N. Esophageal stenosis. Indian Pediatr, 1996 Oct;33(10):861–3.
[17] Mittal SK, Rao S, Rastogi A, Aggarwal V, Kumari S. Hepatitis B--potential of perinatal transmission in India. Trop Gastroenterol, 1996 Jul-Sep;17(3):190–2.
[18] Mittal SK, Aggarwal V. Hepatitis B vaccination in the expanded programme of immunization. Trop Gastroenterol, 1996 Jul-Sep;17(3):188-90.
[19] Rajeshwari K, Jaggi N, Aggarwal V, Kalra KK, Mittal SK, Baveja U. Determinants of symptomatic giardiasis in childhood. Trop Gastroenterol, 1996 Apr-Jun;17(2):70–6.
[20] Mittal SK, Aggarwal V, Kalra KK. Gastro-intestinal endoscopy in children. Trop Gastroenterol, 1996 Apr-Jun;17(2):35–42.
[21] Mittal SK. Heat illnesses in children. Indian Pediatr, 1981 Jun;18(6):401–4.
[22] Mittal SK, Saxena S, Mundkur N, Srivastava G, Gupta S. Acute diarrhea in malnourished children. Clinical, biochemical and bacteriological profile. Indian Pediatr, 1980 Mar;17(3):247-54.
[23] Mundkur N, Mittal SK. Isolated pyogenic liver abscess in a child following measles. Indian Pediatr, 1980 Feb;17(2):179–80.
[24] Saxena S, Anand NK, Saini L, Mittal SK. Bacterial infections among home delivered neonates. Clinical picture and bacteriological profile. Indian Pediatr, 1980 Jan;17(1):17–24.
[25] Mittal SK. Febrile convulsions. Indian Pediatr, 1979 Sep;16(9):741–2.
[26] Mittal SK, Gulati A, Kumari P, Bala V, Gupta S. Seroconversion following measles immunisation. Indian Pediatr, 1979 Apr;16(4):309–11.
[27] Mittal SK, Khanna SR, Gupta A. Diazepam therapy in post neonatal pediatric tetanus. Indian Pediatr.,1979 Mar;16(3):255–7. [28] Mittal SK, Zaidi I, Puri N, Duggal S, Rath B, Bhargava SK. Communication disabilities: emerging problems of childhood. Indian Pediatr, 1977 Oct;14(10):811–5.
[29] Jain TS, Mittal SK. Diarrhea and dehydration in pediatric practice. Indian Pediatr, 1977 May;14(5):401–4.
[30] Bhargava SK, Mittal SK, Kumari S, Kumar A, Ghosh S. Heat injury in the newborn. Indian J Med Res, 1977 May;65(5):688–95.
[31] Ghosh S, Gidwani S, Mittal SK, Verma RK. Socio-cultural factors affecting breast feeding and other infant feeding practices in an urban community. Indian Pediatr, 1976 Nov;13(11):827–32.
[32] Hooja V, Ghosh S, Mittal SK, Verma RK. Immunisation status in an urban community. Indian Pediatr, 1976 Oct;13(10):747–50. [33] Mittal SK, Singh PA, Gupta RC. Intrauterine growth and low birth weight criteria in Punjabi infants. Indian Pediatr, 1976 Sep;13(9):679–82.
[34] Ghosh S, Rath B, Mittal SK. Physical growth in Delhi children: some observations. Indian J Physiol Pharmacol, 1976;20(5 Suppl 1):277-80.
[35] Mittal SK, Mitra AK, Berry AM, Ghosh S. A study of heat hyperpyrexia in infants and children. Indian Pediatr, 1974 Sep;11(9):623-7.
[36] Bhargava SK, Mittal SK, Saxena HM, Sagreiya K. An outbreak of necrotizing enterocolitis in a special care newborn nursery. Indian Pediatr, 1973 Sep;10(9):551–3.
[37] Sinclair S, Mittal SK, Basu N, Ghai OP, Bhide NK. Hazard from lead to children in Delhi. Indian Pediatr, 1973 Jan;10(1):13–8. [38] Mittal SK, Kumar V, Sinclair S. Letterer-Siwe disease. Report of a case. Indian J Pediatr, 1971 May;38(280):246–9.
[39] Sinclair S, Mittal SK, Singh M. Neonatal transfusion malaria. (A case report). Indian Pediatr, 1971 May;8(5):219–20.
[40] Mittal SK, Sinclair S. Criggler-Najjar syndrome. Report of a case. Indian J Pediatr, 1971 Jan;38(276):39–41.
[41] Mittal SK. Upper gastrointestinal endoscopy in children. Indian Pediatr, 1989 Feb;26(2):134–8.
[42] Sachdev HP, Mittal NK, Mittal SK, Yadav HS. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. J Pediatr Gastroenterol Nutr, 1988 Nov-Dec;7(6):877–81.
[43] Mittal SK. National workshop on child health and manpower: 2000 AD. Indian Pediatr, 1988 Jul;25(7):667–72.
[44] Saluja S, Mittal SK, Varghese A, Ramachandran VG. Role of enteroinvasive E. coli in acute invasive diarrhea. Indian Pediatr, 1988 May; 25(5):422–7.
[45] Mittal SK. Bowel pattern and weight gain in breast fed infants. Indian Pediatr, 1988 Feb;25(2):216–7.
[46] Kapoor R, Gomber S, Saha MM, Chaturvedi U, Mittal SK, Gupta AK. Malignant pleural mesothelioma in a child—a case report. Australas Radol, 1988 Feb;32(1):134–7.
[47] Rastogi V, Singhal PK, Aseri A, Khalil A, Taneja SB, Mittal SK. Trichobezoars. Indian J Gastroenterol, 1988 Jan;7(1):55–6.
[48] Mittal SK, Lloyd D, Brown G, McNeish AS. Thymidine kinase and disaccharidase activities in intestinal mucosa in health and disease. Indian Pediatr, 1988 Jan;25(1):51–5.
[49] Mittal SK, Kanwar A, Saluja S, Nakra S. Enteropathogens, feeding practices and biochemical disturbances in diarrheal dehydration. Indian Pediatr, 1987 Nov;24(11):999–1005.
[50] Mittal SK. Oral rehydration: universal solution. Indian Pediatr, 1986 Nov; 23(11):895-7.
[51] Mittal SK, Gupta RK. Heat stroke [Review]. Indian Pediatr, 1986 Oct; 23(Suppl):155-60.
[52] Mehta R, Saini L, Mittal SK. A critical evaluation of B.C.G. test applicability in pediatric practice. Indian Pediatr, 1986 Jun;23(6):419–28.
[53] Kanwar A, Mittal SK, Ramachandran VG, Varghese A. Antibiotic resistance of gram negative rectal flora. Indian Pediatr. 1984 Sep;21(9):729–35.
[54] Nakra SK, Mittal SK, Sarkar R. Enzyme linked immunosorbent assay (ELISA) for detection of rotavirus in acute gastroenteritis. Indian Pediatr, 1984 Jun;21(6):457–62.
[55] Kanwar A, Mittal SK, Ramachandran VG, Varghese A. A critical study of Escherichia coli as a pathogen in acute gastroenteritis. Indian Pediatr, 1983 Feb;20(2):113–9.
[56] Mittal SK, Kanwar A, Varghese A, Ramachandran VG. Gut flora in breast and bottle fed infants with and without diarrhea. Indian Pediatr, 1983 Jan;20(1):21–6.
[57] Narula P, Mittal SK, Gupta S, Saha K. Cellular and humoral factors of human milk in relation to nutritional status in lactating mothers. Indian J Med Res, 1982 Sep;76:415–23.
[58] Bhargava SK, Mittal SK. The challenge of infant mortality--need for a national commitment. Indian Pediatr, 1982 Apr;19(4):287–9.
[59] Saini G, Mittal SK, Tayal G, Saini L. Chloramphenicol kinetics in malnutrition. Indian Pediatr, 1981 Nov;18(11):805–10.
[60] Kumari S, Mittal SK, Gupta S, Mishra SL, Roy DD. Family welfare and child health: a reappraisal of community based postpartum programme. Indian Pediatr, 1981 Sep;18(9):619–23.
[61] Bhardwaj A, Aggarwal V, Chakravarty A, Mittal SK. Does Rota virus infection cause persistent diarrhoea in childhood? Trop Gastroenterol, 1996 Jan-Mar;17(1):18–21.
[62] Mittal SK. Pulse immunization against poliomyelitis in India. Indian Pediatr, 1995 Aug;32(8):939–40; discussion 940-2.
[63] Mittal SK. Pediatric gastroenterology. Trop Gastroenterol, 1995 Apr-Jun;16(2):72–3.
[64] Aggarwal V, Mittal SK, Kumar N, Chowdhury V. A comparative study of double contrast barium enema and colonoscopy for evaluation of rectal bleeding in children. Trop Gastroenterol, 1995 Apr-Jun;16(2):132–7.
[65] Jaggi N, Rajeshwari S, Mittal SK, Mathur MD, Baveja UK. Assessment of the immune and nutritional status of the host in childhood diarrhoea due to cryptosporidium. J Commun Dis, 1994 Dec;26(4):181–5.
[66] Mittal SK, Kalra KK, Aggarwal V. Diagnostic upper GI endoscopy for hemetemesis in children: experience from a pediatric gastroenterology centre in north India. Indian J Pediatr, 1994 Nov-Dec;61(6):651–4.
[67] Mittal SK, Aggarwal V, Kalra KK. Chronic diarrhea in children of tropics. Indian J Pediatr. 1994 Nov-Dec;61(6):635–42.
[68] Mittal SK, Rao S, Kumari S, Aggarwal V, Prakash C, Thirupuram S. Simultaneous administration of hepatitis B vaccine with other E.P.I. vaccines. Indian J Pediatr, 1994 Mar-Apr;61(2):183–8.
[69] Chhabra P, Garg S, Mittal SK, Satyanarayan L, Mehra M, Sharma N. Magnitude of acute respiratory infections in under five. Indian Pediatr, 1993 Nov;30(11):1315–9.
[70] Chakravarti A, Broor S, Natarajan R, Setty VS, Mittal SK. Epidemiological and clinical characteristics of acute diarrhoea in children due to human rotavirus. J Trop Pediatr, 1992 Aug;38(4):192–3.
[71] Chakravarti A, Kumar S, Mittal SK, Broor S. Clinical and epidemiological features of acute gastroenteritis caused by human rotavirus subgroups. J Diarrhoeal Dis Res, 1992 Mar;10(1):21–4.
[72] Taneja K, Mittal SK, Marya SK, Mehrotra G, Shiv VK, Bhargava SK. Acute osteomyelitis: early diagnosis by ultrasonography. Australas Radiol, 1992 Feb;36(1):77–9.
[73] Chowdhary V, Gulati P, Sachdev A, Mittal SK. Pyogenic meningitis: sonographic evaluation. Indian Pediatr, 1991 Jul;28(7):749–55.
[74] Chakravarti A, Kumar S, Mittal SK, Broor S. Comparison of latex agglutination and polyacrylamide gel electrophoresis with enzyme linked immunosorbent assay for detecting human rotavirus in stool specimens. Indian Pediatr, 1991 May;28(5):507–10.
[75] Khalil A, Chadha V, Mandapati R, Mathur NB, Mittal SK, Gulati P, Chowdhury V, Tyagi S, Khalilullah M. Hemobilia in a child with liver abscess. J Pediatr Gastroenterol Nutr, 1991 Jan;12(1):136–8.
[76] Mittal SK, Aggarwal V. Acute respiratory infections. Indian Pediatr, 1990 Sep;27(9):1000–7.
[77] Mittal SK, Ramji S. Child health and manpower: 2000 AD. Indian Pediatr, 1990 Jun;27(6):549–56.
[78] Mittal SK, Ramji S. Health services in urban India. Indian J Pediatr, 1989 Nov-Dec;56(6):679–81.
[79] Mittal SK, Ramji S. Health for all and rural Medicare. Indian J Pediatr. 1989 Sep-Oct;56(5):559–62.
[80] Mittal SK. Polio vaccination. Indian Pediatr, 1989 May;26(5):509.
[81] Verma IC, Mittal SK, Ghai OP. Autoimmune hemolytic anemia in infancy and childhood. Indian J Pediatr, 1970 Jul;37(270):326–31.
[82] Mittal SK. Consumptive coagulopathy. Indian J Pediatr, 1970 Feb; 37(265):73–6.
[83] Mittal SK. Cerebellar disorders in childhood. A review. Indian J Pediatr, 1969 Aug;36(259):294–300.
[84] Singh M, Mittal SK. Exchange transfusion in the newborn. A four-year experience. Indian J Pediatr, 1969 May;36(256):161–8.
[85] Sethi AS, Verma IC, Mittal SK, Khanna KK. Idiopathic hypoparathyroidism. Report of two cases. Indian J Pediatr, 1968 Oct;35(249):490–5.
Editor (Egypt)
Ali Saber Mohamed, MB, BCH, D Psych
Dr. Ali S. Mohamed serves as a neuropsychiatrist at Al-Soliman Hospital in Port Said, Egypt. His scientific interests include developmental disorders (e.g., autism, ADHD, and learning disorders), schizophrenia and bipolar disorder, as well as the neurobiological, cognitive, and behavioral basis of disorders. He has authored three books in UAE, Sharjah.
Dr. Mohamed shared in the establishment of the Pan African Federation of Disabled People. He also serves as head physician of the committee of rehabilitation in Port Said governorate, Egypt.
Dr. Mohamed is highly concerned with Psychology and Legislation of disability, as he himself had his right leg amputated at 15 years old.
Education
• Bachelor of Medicine December 1987
• Master Thesis on Prevalence of Disability among children attending health centers, 1993
• Resident physician Physical Med. And Rehab. until 1993
• Resident physician Psychiatry 1993 – 2000
• Diploma of Neurological and Psychiatric diseases, 2000
• Specialist of Neuropsychiatry since 2000
•
Books
• Psycho-social Aspects of Disability
• Family of disabled child
• Characteristics of children 1-18 years old
In press
1) Mental Retardation
2) Child Personality
Articles
Many on medical, neurologic and psychiatric issues in Arabic magazines.
1) Series in the Monthly (Almanal Magazine, UAE, Sharjah) as regular writer:
- Autism Diagnosis and Treatment
- Psychology of disability
- Family of disabled child
- Disabled people in war time and disasters
- Stem cells in medicine
- How media portrayed disabled
- Others
2) Schizophrenic can kill. Rose Al-Yousef Magazine, Egypt
3) Mental Health of Deaf. Proceedings of 8th Conference of Arab Deaf Association 2005, Tunisia.
4) How Disabled can reach media. Proceedings of 4th annual meeting of almanal at UAE 2005.
5) Legislation and disability. The quarterly magazine of Egyptian Disabled Association.
Editor (California, United States)
Garth L. Nicolson, PhD
Professor Garth L. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. Born in 1943 in Los Angeles, Dr. Nicolson received his B.S. in Chemistry from University of California at Los Angeles in 1965 and his Ph.D. in Biochemistry and Cell Biology from the University of California at San Diego in 1970. He is currently Professor of Integrative Medicine at Capitol University of Integrative Medicine and a Conjoint Professor at the University of Newcastle (Australia). He was formally the David Bruton Jr. Chair in Cancer Research and Professor and Chairman of the Department of Tumor Biology at the University of Texas M. D. Anderson Cancer Center in Houston, and he was Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Professor of Comparative Pathology at Texas A & M University.
Professor Nicolson has published over 550 medical and scientific papers (including 3 Current Contents Citation Classics), edited 14 books, served on the Editorial Boards of 20 medical and scientific journals. Professor Nicolson has won many awards, such as the Burroughs Wellcome Medal of the Royal Society of Medicine (United Kingdom), Stephen Paget Award of the Metastasis Research Society, the U. S. National Cancer Institute Outstanding Investigator Award, and the Innovative Medicine Award of Canada. He is also a Colonel (Honorary) of the U. S. Army Special Forces and a U. S. Navy SEAL (Honorary) for his work on Armed Forces and veterans’ illnesses.
Professional Experience
Primary Appointment
1996-Present, President, Chief Scientific Officer and Research Professor, The Institute for Molecular Medicine, 16371 Gothard Street H, Huntington Beach, CA 92647
Secondary Appointments
2003-Present, Conjoint Professor, Faculty of Science and Technology, University of Newcastle, Newcastle, Australia
2001-Present, Professor of Integrative Medicine, Capital University of Integrative Medicine, Washington DC
Previous Appointments
1989-99, Professor, Department of Internal Medicine, The University of Texas Medical School, Houston, TX
1981-98, Adjunct Professor, Department of Pathology, School of Veterinary Medicine, Texas A & M University, College Station, TX
1982-98, Professor, Department of Pathology and Laboratory Medicine, The University of Texas Medical School, Houston, TX
1980-96, David Bruton Jr. Chair in Cancer Research, Professor and Chairman, Tumor Biology, The University of Texas
M. D. Anderson Cancer Center, Houston, TX
1980-96, Professor, The Graduate School of Biomedical Sciences, The University of Texas Health Science
Center, Houston, TX
1980-87, Florence M. Thomas Professor of Cancer Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX
1978-80, Professor, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, CA
1977-80, Associate Director, Oncology Program, University of California, Irvine, CA
1975-80, Professor, Department of Developmental and Cell Biology, University of California, Irvine, CA
1974-76, Chairman, Department of Cancer Biology, The Salk Institute, La Jolla, CA
1972-74, Head, Cancer Council Laboratory, Director, Electron Microscopy Laboratory, The Salk Institute, La Jolla, CA
1970-71, Senior Research Associate, Cancer Council Laboratory, The Salk Institute, La Jolla, CA
1967-70, USPHS Predoctoral Fellow University of California, San Diego, CA
National and International Committee Memberships
Member, Board of Advisors, The Healthy Foundation, 2001-present
Member, Board of Advisors, Road Back Foundation, 2000-present
Member, Susan Koman Foundation for Breast Cancer Research Review Committee, 1995-98
Chairman, Medical-Scientific Panel, Persian Gulf War Veterans Conference, 1995
Chairman, American Cancer Society Review Committee, Personnel B Review Committee, 1990-94
Chairman, USAMRDC Review Committee on Breast Cancer, Endocrinology-2 Committee, 1994
Member, Extramural Scientific Advisory Committee, Moffitt Cancer Center, The University of South Florida, 1995-98
Member, Extramural Scientific Advisory Committee, The University of Arizona Health Sciences Center, 1991-99
Member, Extramural Scientific Advisory Committee, Roswell Park Memorial Institute, Buffalo, NY, 1988-93
Member, Extramural Scientific Advisory Committee, The University of Nebraska Health Sciences Center, 1994-96
Reviewer, National Cancer Institute Cancer Centers Program, 1974-93
Member, National Cancer Institute Large Bowel Cancer Project, 1984-88
Member, National Cancer Institute Organ Systems Program, 1984-88
Member, National Cancer Institute Construction Review Committee, 1982-86
Member, National Cancer Institute Breast Cancer Task Force, 1983-86
Chairman, American Cancer Society Review Committee, Cell and Developmental Biology, 1979‑83
Member (Ad Hoc), NIH Pathology B Study Section, 1976-81
Member, U.S.-Japan Cooperative Cancer Research Program, 1976-80
Member, Advisory Committee, Division of Cancer Cause and Prevention, National Cancer Institute, 1974-79
Member, National Cancer Institute Virus-Cancer Program Review Committee, 1974-79
Member, World Health Organization Task Force on Human Fertility, 1973-76
Editor
· Clinical & Experimental Metastasis (Founding Editor)
· Journal of Cellular Biochemistry (Field Editor)
· Cell Surface Reviews, 1975-88
· Experimental Cell Research, 1978-94
Associate Editor
· Biochimica et Biophysica Acta, 1973-79
· Cancer Biology Reviews, 1978-84
· Cancer Communications, 1988-92
· Cancer & Metastasis Reviews
· Cancer Molecular Biology; Cancer Research, 1981-84, 1985-89, 1990-95
· Cancer Reviews, 1984-90
· Current Cancer Treatment Reviews
· Experimental Cell Biology, 1985-91
· Experimental Cell Research, 1978-94
· Gamete Research, 1978-84
· International Journal of Cancer, 1984-93
· International Journal of Molecular Biology
· Invasion & Metastasis, 1974-99
· Journal of the American Nutraceutical Association
· Journal of Chronic Fatigue Syndrome
· Journal of Experimental Therapeutics and Oncology
· Molecular Biology of Cancer
· Molecular & Cellular Biochemistry
· Natural Immunity & Cell Growth Regulation,1985-89
· Oncology Research, 1990-03
· Pathobiology, 1991-99
· Receptors & Recognition, 1975-79
· Yearbook of Cancer, 1982-87
Honors and Awards
· Innovative Medicine Award (Canada), 2002
· Stephen Paget Award, Metastasis Research Society, 1998
· Albert Schweitzer Award, Portugal, 1998
· First Norman N. Durham Lectureship, OSU, 1996
· Indo-American Society for Health & Laboratory Professionals Award, 1996
· Distinguished Presentation Award, Third International Cancer Molecular Biology Symposium, 1996
· COLONEL (Honorary), U. S. Army Special Forces, 1995
· SEAL (Honorary), U.S. Navy Special Forces, 1995
· Haskel Visiting Professorship, University of Pennsylvania, 1995
· Burroughs Wellcome Medal, Royal Society of Medicine Foundation, London, 1991
· Outstanding Faculty Award, The University of Texas Health Sci ence Center at Houston, 1991
· National Cancer Institute, U.S.S.R. Scientist Exchange Award for Collaborative Research on Molecular and Genetic Aspects of Tumor Metastasis, 1991
· Evan and Marion Helfaer Distinguished Lectureship, The Cancer Center of the Medical College of Wisconsin, 1990
· Dean's Teaching Excellence List, The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, 1985-1994
· Teaching Excellence Award for Best Course, The University of Texas Medical School at Houston, 1990
· NCI Outstanding Investigator Award, 1987
· Annual Award of the Japan Histochemical Society, 1976
· Eli Nadel Memorial Lecture in Biochemistry, 1983
· Rita Ferdinand Memorial Lectureship, 1982
· Guy Lipscomb Memorial Lecture in Chemistry, 1980
· Upjohn Biology Education Award, 1976
· Presidential Award, Electron Microscopy Society of America, 1971
Society Memberships with Offices Held
· American Association for Cancer Research
Member, Board of Directors, 1985-1988; Chairman, Rhoades Award Committee, 1987-1988; Chairman, Nomination Committee, 1985-1988; Member, Program Committee, 1984-1988; Member, Local Arrangements Committee, 1991.
· Metastasis Research Society
President, 1988-90; Sec. Treas., 1990-98; Vice Pres., 1986-88.
· American Academy of Environmental Medicine
· American College for the Advancement of Medicine
· American Society of Biological Chemists
· American Society for Cell Biology
· Biophysical Society
· Electron Microscopy Society of America
· New York Academy of Sciences
U.S. Congressional Committee and Presidential Commission Testimony
· Testimony of Dr. Garth L. Nicolson, House Committee on Government Reform, Subcommittee on National Security, Veterans' Affairs and International Relations, United States House of Representatives, January 24, 2002.
· Testimony of Dr. Garth L. Nicolson, House Committee on Veterans' Affairs, Subcommittee on Health, United States House of Representatives, January 24, 2002.
· Testimony Of Dr. Garth L. Nicolson, Special Oversight Board For Department Of Defense Investigations Of Gulf War Chemical And Biological Incidents, U. S. Senate Hart Office Building SH-216, November 19, 1998.
· Testimony Of Dr. Garth L. Nicolson, House Committee on Veterans' Affairs, Subcommittee on Benefits, United States House of Representatives, July 16, 1998.
· Testimony Of Dr. Garth L. Nicolson and Dr. Nancy L. Nicolson, House Committee On Government Reform and Oversight, Subcommittee on Human Resource and Intergovernmental Relations, United States House of Representatives, June 26, 1997.
· Testimony of Dr. Garth L. Nicolson and Dr. Nancy L. Nicolson, House Committee On Government Reform And Oversight, Subcommittee on Human Resource and Intergovernmental Relations, United States House of Representatives, April 2, 1996.
· Testimony of Garth Nicolson and Nancy L. Nicolson, Mycoplasmal Infections in Gulf War Illnesses, President's Advisory Panel on Gulf War Veterans’ Illnesses, Washington D.C., August 14-16, 1995.
Patents Pending and Granted
U.S. Patent Issued: (No. 4,859,581) Endoglycosidase Assay, invented by GL Nicolson, M Nakajima, T Irimura, 1989.
U.S. Patent Issued: (No. 5,030,559) Methods and Compos-itions for the Identification of Metastatic Human Tumors, invented by GL Nicolson, SM North, PA Steck, 1991.
U.S. Patent Issued: (No. 5,164,489) Lung Growth Stimulatory and Inhibitory Factors for Carcinoma Tumor Cells, invented by GL Nicolson, PG Cavanaugh, 1992.
U.S. Patent Issued: (No. 5,262,403) Glycosaminoglycan Derivatives and their use as Inhibitors of Tumor Invasiveness or Metastatic Profusion-II, invented by GL Nicolson, T Irimura, M Nakajima, 1993.
U.S. Patent Pending: (UTMDACC:115) Metastasis Associated Collagenolytic Metalloproteinase, invented by M Nakajima, GL Nicolson.
U.S. Patent Pending: (UTMDACC:193) Immunochemical Localization of Heparanase in Mouse and Human Melanomas, invented by GL Nicolson, L Jin, M Nakajima.
U.S. Patent Issued: (No. 5,332,812) Endoglycosidase Immunoassay, invented by GL Nicolson, M Nakajima, T Irimura.
U.S. Patent Pending: (UTDMACC:270) Liver-Derived Tumor Cell Growth Inhibitor, invented by PG Cavanaugh, GL Nicolson.
U.S. Patent Pending: (UTDMACC:387) Metastasis-Associated Gene, invented by GL Nicolson, Y Toh, and S Pencil.
Publications
Of the some 550 manuscripts authored or co-authored by Garth L. Nicolson from 1969 through 2004, below is a listing of the most recent 120 manuscripts published between 1997 and 2004.
[1] Wakabayashi H, Nicolson GL. Transfilter cell invasion assays. In: Cell Biology: A Laboratory Handbook, JE Celis, ed., Academic Press, New York, 1997;1:296–301.
[2] Nicolson GL. Breast cancer metastasis-associated genes: role in tumor progression to the metastatic state. In: Mammary Development and Cancer, P.S. Rudland, D.G. Fernig, S. Leinster, G.G. Lunt, eds., The Biochemical Society Symp, 1997;63: 231–43.
[3] Yun Z, Smith TW, Menter DG, McIntire LV, Nicolson GL. Differential adhesion of metastatic RAW117 large-cell lymphoma cells under static or hydrodynamic conditions: role of integrin αvβ3. Clin. Expl. Metastasis, 1997;15:3–11.
[4] Ahn SH, Sawada H, Ro JY, and Nicolson GL. Expression of annexin I in human mammary ductal epithelial cells from normal tissue and benign and malignant breast lesions. Clin. Expl. Metastasis, 1997;15:151–6.
[5] Go Y, Chintala SK, Mohanam S, Gokaslan Z, Bjerking R, Oka K, Nicolson GL, Sawaya R, Rao JS. Inhibition of in vivo tumorigenicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors. Clin. Expl. Metastasis, 1997;15:440–6.
[6] Marchetti D, Nicolson GL. Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Adv. Enzyme Regul, 1997;37:111–34.
[7] Toh Y, Oki E, Oda S, Tokunaga E, Ohno S, Maehara Y, Nicolson GL, Sugimachi K. Overexpression of MTA1 gene in colorectal and gastrointestinal carcinomas: correlation with invasion and metastasis. Intern. J. Cancer, 1997;74:459–63.
[8] Nicolson GL, Nicolson NL. The eight myths of Operation Desert Storm and Gulf War Syndrome. Medicine, Conflict & Survival, 1997;13:140–6.
[9] Go Y, Chintala SK, Rayford A, Gagercas E, Ali-Osman F, Venkaiah B, Sawaya R, Gokaslan Z, Nicolson GL, Rao JS. Inhibition of in vivo tumorigenicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors. Clin. Expl. Metastasis, 1996;15:440–6.
[10] Nicolson GL, Nicolson NL, Nasralla M. Mycoplasmal infections and Fibromyalgia/Chronic Fatigue Illness (Gulf War Illness) associated with deployment to Operation Desert Storm. Intern. J. Med, 1997;1:80–92.
[11] Go Y, Chintala SK, Rayford A, Gagercas E, Ali-Osman F, Venkaiah B, Sawaya R, Gokaslan Z, Nicolson GL, Rao JS. Cisplatin but not BCNU inhibits urokinase-type plasminogen activator levels in human glioblastoma cell lines in vitro. Clin. Expl. Metastasis, 1997;15:447–52.
[12] Cavanaugh PG, Nicolson GL. Selection of highly metastatic rat MTLn2 mammary adenocarcinoma cell variants using in vitro growth response to transferrin. J. Cell. Physiol, 1997;174:48–57.
[13] Rao VH, Singh RK, Bridge JA, Neff JR, Scoffer GB, Delaminate DC, Dunn CM, Sager WG, Buehler BA, Sawaya R, Nicolson GL, Rao JS. Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone. Clin. Expl. Metastasis, 1997;15:400–9.
[14] Marchetti D, Nicolson GL. Human melanoma cell invasion: Selected neurotrophin enhancement of melanoma invasion and heparanase activity. J. Investig. Determatol. Symp. 1997;2:99–105.
[15] Hu M, Pollock RE, Nicolson GL. Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells. Identification as an N-terminal fragment of human fibronectin. Cancer Res, 1997;57: 3577–84.
[16] Nicolson GL, Nakajima M, Wakabayashi H, Boyd D, Diaz D, Irimura T. Cancer cell heparanase associated with invasion and metastasis. Adv. Enzyme Regulat, 1998;38:19–32.
[17] Moustafa A, Nicolson GL. Breast cancer metastasis-associated genes: prognostic significance and therapeutic implications. Oncol. Res, 1998; 9:505–25.
[18] Nicolson GL, Nicolson NL. Gulf War Illnesses: complex medical, scientific and political paradox. Med. Conflict & Survival, 1998; 14:156–65.
[19] Nicolson NL, Nicolson GL. Politics interfere with diagnosis and treatment of Gulf War Illnesses. Intern. J. Med, 1998;1:161–4.
[20] Gokaslan ZL, Chintala SK, York JE, Boyapati V, Jasti S, Sawaya R, Fuller G, Wildrick DM, Nicolson GL, Rao JS. Expression and localization of urokinase-type plasminogen activator in human spinal column tumors. Clin. Expl. Metastasis, 1998;16:713–9.
[21] Nicolson GL. Chronic infections as a common etiology for many patients with Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. Intern. J. Med, 1998;1:42–6.
[22] Gokaslan ZL, Chintala SK, York JE, Boyapati V, Jasti S, Sawaya R, Fuller G, Wildrick DM, Nicolson GL, Rao JS. Expression and role of matrix metalloporteinases MMP-2 and MMP-9 in human spinal column tumors. Clin. Expl. Metastasis, 1998;16:721–8.
[23] Nicolson GL, Nicolson NL, Nasralla M. Mycoplasmal infections and Chronic Fatigue Illness (Gulf War Illness) associated with deployment to Operation Desert Storm. Intern. J. Med, 1998;1:80–92.
[24] Nicolson GL. Considerations when undergoing treatment for chronic infections found in Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. Part 1: Commentary. Part 2: Antibiotics and General Considerations. Intern. J. Med, 1998;1:115–7 (Part 1), 123–8 (Part 2).
[25] Nicolson GL, Nasralla M, Hier J, Nicolson NL. Diagnosis and treatment of chronic mycoplasmal infections in Fibromyalgia Syndrome and Chronic Fatigue Syndrome: relationship to Gulf War Illness. Biomed. Therapy, 1998;16:266–71.
[26] Nicolson GL, Moustafa AS. Metastasis-associated genes and metastatic tumor progression. In Vivo, 1998;12:579–88.
[27] Haier J, Nasralla M, Buhr HJ, Nicolson GL. Different integrin-mediated adehsion of poorly and highly metastatic colon carcinoma cell lines on extracellular matrix. Langebecks Arch. Surg, 1998;103:307–13.
[28] Leisure KM, Nicolson NL, Nicolson GL. Hospitalizations for unexplained illnesses among U.S. veterans of the Persian Gulf War. [letter] Emerg. Infect. Dis, 1998;4:707–9.
[29] Nasralla M, Haier J, Nicolson GL. Mycoplasmal infections in blood from patients with Chronic Fatigue Syndrome, Fibromyalgia Syndrome or Gulf War Illness. In: The Clinical and Scientific Basis of Chronic Fatigue Syndrome, TK Roberts, ed., Proc. Intern. CFS Congress, Lloyd Scott Enterp., Sydney, 1998:16–20.
[30] Toh Y, Kuwano H, Mori M, Nicolson GL, Sugimachi K. Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. Brit. J. Cancer, 1999;79:1723–6.
[31] Cavanaugh PG, Jia L, Nicolson GL. Transferrin receptor overexpression enhances transferrin responsiveness and the metastatic capability of a rat mammary adenocarcinoma cells. Breast Cancer Res. Treat, 1999;56:203–17.
[32] Nicolson GL. Brain invasion, trophic factors and central nervous system metastasis. In: Brain Tumor Invasion: Biological, Clinical and Therapeutic Considerations, R. Bjerkvig, OD Laerum, ML Rosenblum, eds., Wiley-Liss, NY, 1999:357–74.
[33] Haier J, Nasralla M, Franco AR, Nicolson GL. Detection of mycoplasmal infections in blood of patients with rheumatoid arthritis. Rheumatol, 1999;38:504–9.
[34] Haier J, Nicolson GL. Role of the vascular endothelium in cancer metastasis. In: Intramolecular Cross-talk in Metastasis, G Skouteris, GL Nicolson, eds., NATO ASI series, IOS Press, Amsterdam, 1999:225–49.
[35] Nicolson GL, Moustafa M. Gene expression in tumor metastasis and malignant cell progression. In: Intramolecular Cross-talk in Metastasis, G Skouteris, GL Nicolson, eds., NATO ASI series, IOS Press, Amsterdam, 1999:1–9.
[36] Haier J, Nasralla M, Nicolson GL. Different adhesion properties of poorly and highly metastatic HT-29 colon carcinoma cell lines with extracellular matrix components: role of integrin expression and cytoskeletal components. Brit. J. Cancer, 1999;80:1867–74.
[37] Nicolson GL, Nasralla M, Haier J, Erwin R, Nicolson NL, Ngwenya R. Mycoplasmal infections in chronic illnesses: Fibromyalgia and Chronic Fatigue Syndromes, Gulf War Illness, HIV-AIDS and Rheumatoid Arthritis. Med. Sentinel, 1999;4:172–6.
[38] Haier J, Nasralla M, Nicolson GL. Influence of phosphotyrosine kinase inhibitors on adhesive properties of highly and poorly metastatic HT-29 colon carcinoma cells to collagen. Int. J. Colorectal Dis, 1999;14:119–27.
[39] Nasralla M, Haier J, Nicolson GL. Multiple mycoplasmal infections detected in bood of Chronic Fatigue Syndrome and Fibromyalgia Syndrome patients. Eur. J. Clin. Microbiol. Infect. Dis, 1999;18:859–65.
[40] Nicolson GL. The role of microorganism infections in chronic illnesses: support for antibiotic regimens. CFIDS Chronicle, 1999;12(3):19–21.
[41] Zucker S, Hymowitz M, Conner C, Zarrabi HM, Hurewitz AN, Matrisian L, Boyd D, Nicolson GL, Montana S. Measurement of matrix metallo-proteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in blood and tissues: clinical and experimental applications. Ann. N. Y. Acad. Sci, 1999;818:212–27.
[42] Haier J, Nasralla M, Nicolson GL. β1-integrin mediated dynamic adhesion of colon carcinoma cells to extracellular matrix under laminar flow. Clin. Expl. Metastasis, 1999;17:377–87.
[43] Nicolson NL, Nicolson GL. Nucleoprotein Gene Tracking: localization of specific HIV-1 genes to subchromatin nucleprotein complexes in HIV-1 infected human cells. J. Cell. Biochem, 1999;32(Suppl):158–65.
[44] Nicolson GL, Nasralla M, Nicolson NL. The pathogenesis and treatment of mycoplasmal infections. Antimicrob. Infect. Dis. Newsl, 1999; 17(11): 81–8.
[45] Nicolson GL, Nasralla M, Haier J, Erwin R, Nicolson NL, Ngwenya R. The role of chronic infections in the maintainance and progression of Chronic Fatigue Syndrome, Fibromyalgia Syndrome Rheumatoid Arthritis, Immune Deficiency Syndromes and Gulf War Illness. In: The Challenge of Chronic Illness: A role for Complex Infections and Channel-opathy, TK Roberts, ed., Lloyd Scott Enterp. Ltd., Sydney, Australia, 1999;1–8.
[46] Haier J, Nicolson GL. Role of the cytoskeleton in adhesion stabilization of human colorectal carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow. Clin. Expl. Metastasis, 1999;17:713–21.
[47] Haier, J. and Nicolson, G.L. Tumor cell adhesion of human colon carconoma cells with different metastatic properties to extracellular matrix under dynamic conditions of laminar flow. J. Cancer Res. Clin. Oncol, 2000;126:699–709.
[48] Nicolson NL, Nicolson GL. HIV-1 genes are localized in specific nucleoproteins in subchromatin complexes in HIV-1 infected human cells. Int. J. Med. Biol. Environ,2000;28(1):25–31.
[49] Haier J, Nasralla M, Nicolson GL. Cell Surface molecules and their prognostic values in assessing colorectal carcinomas. Ann. Surgery, 2000;231(1):11–24.
[50] Papadimitriou MNB, Menter DM, Konstantopoulos K, Nicolson GL, and McIntire LV. Integrin α4β1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under laminar flow. Clin. Expl. Metastasis, 2000;17:669–76.
[51] Haier J, Nicolson GL. Role of the cytoskeleton in adhesion stabilization of human colorectal carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow. Clin. Expl. Metastasis, 2000;17:713–21.
[52] Toh Y, Kininaka S, Endo H, Ohshiro T, Ikeda Y, Nakashima H, Baba H, Kohnoe S, Okamura T, Nicolson GL, Sugimachi K. Molecular analysis of a candidate metastasis-associate gene mta1: interaction with histone deacetylase. J. Exp. Clin. Cancer Res, 2000;19:105–11.
[53] Nicolson GL, Nass M, Nicolson NL. Safety and efficacy problems with the anthrax vaccine. Why we must not use this vaccine for military personnel. J. Degenerative Disease, 2000; 2(1): 5–11.
[54] Haier J, Nicolson GL. Time-dependent dephosphorylation through Ser/Thr phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cells to collagen. Anticancer Res, 2000;20: 2265–71.
[55] Nasralla M, Haier J, Nicolson NL, Nicolson GL. Examination of mycoplasmas in blood of 565 Chronic Illness patients by polymerase chain reaction. Int. J. Med. Biol. Environ, 2000;28(1):15–23.
[56] Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H, Toh Y, Funitaka K, Nicolson GL. Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J. Cell. Biochem, 2000;79:202–12.
[57] Haier J, Nicolson GL. Prognostic value of cell surface molecules in colorectal carcinomas. Visceralchirurgie, 2000;35:172–81.
[58] Nicolson GL, Haier J, Nasralla M, Nicolson NL, Ngwenya R, De Meirleir K. Mycoplasmal infections in Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illness. J. Chron. Fatigue Synd, 2000;6(3/4):23–39.
[59] Mohan PM, Lakka SS, Mohanam S, Yoshiaki K, Sawaya Y, Kyritsis AP, Nicolson GL, Rao JS. Down-regulation of urokinase-type plasminogen activator receptor by antisense construct is due to inhibition of protein translation. Clin. Exp. Metastasis, 2000;17:617–21.
[60] Nicolson GL, Nasralla M, Franco AR, Nicolson NL, Erwin R, Ngwenya R, Berns PA. Diagnosis and integrative treatment of intracellular bacterial infections in Chronic Fatigue and Fibromyalgia Syndromes, Gulf War Illness, Rheumatoid Arthritis and other chronic illnesses. Clin. Pract. Alt. Med, 2000;1(2):92–102.
[61] Nicolson GL, Nass M, Nicolson, NL. Anthrax vaccine: controversy over safety and efficacy. Antimicrob Infect Dis Newsl 2000;18(1):1–6.
[62] Nawa A, Sawada H, Toh Y, Nishimori K, and Nicolson GL. Tumor metastasis-associated human MTA1 gene: effects of antisense oligonucleotides on cell growth. Int. J. Med. Biol. Environ, 2000;28(1):33–9.
[63] Nicolson GL, Nass M, Nicolson NL. The anthrax vaccine controversy. Questions about its efficacy, safety and strategy. Medical Sentinel, 2000;5(2):97–101.
[64] Haier J, Gallick GE, Buhr HJ, Nicolson GL. Adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix is regulated by pp60src under dynamic conditions of laminar flow. Owen Wangensteen Surgical Forum LI, 2000:260–2.
[65] Nicolson GL, Nasralla M, Hier J, Nicolson NL. Gulf War Illnesses: role of chemical, radiological and biological exposures. In: War or Health, H Tapanainen, ed., Zed Press, Helsinki, 2001:431–46.
[66] Haier J, Nicolson GL. Role of tumor cell adhesion as an important factor in formation of distant metastases. Diseases Colon Rect, 2001;44:876–84.
[67] Yanamandra N, Konduri SD, Mohanam S, Dinh DH, Olivero WC, Gujrati M, Nicolson GL, Rao JS. Down-regulation of urokinase-type plasminogen activator receptor (uPAR) induces capase- mediated cell death in human glioblastoma cells. Clin. Expl. Metastasis, 2001; 18:611–5.
[68] Nicolson GL, Nasralla M. Advantages and limitations of models for cancer and malignant cell progression in breast cancer. In: Cancer Handbook, M Alison, ed., Macmillan Publishers, 2001:863-72.
[69] Haier J, Nicolson GL. Cell biology and clinical implications of adhesion molecules in colorectal diseases: colorectal cancers, infections and inflammatory bowel diseases. Clin. Expl. Metastasis, 2001;18:623–38.
[70] Haier J, Nicolson GL. Models for tumor cell adhesion and invasion. In: Cancer Handbook, M Alison, ed., Macmillan Publishers, London, 2001:983–98.
[71] Lakka SS, Jasti SL, Kyritsis AP, Yung WKA, Ali-Osman F, Nicolson GL, Rao JS. Regulation of MMP-9 (Type IV Collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and Jun amino-terminal kinase signaling cascades. Clin. Expl. Metastasis, 2001;18:245–52.
[72] Lakka SS, Konduri SD, Mohanam S, Nicolson GL, Rao JS. In vitro modulation of human lung cancer cell line invasiveness by antisense cDNA of tissue pathway inhibitor-2. Clin. Expl. Metastasis, 2000; 18:239–44.
[73] Marchetti D, Nicolson GL. Human heparanase: a molecular determinant of brain metastasis. Adv. Enzyme Regulat, 2001;41:343–59.
[74] Chandrasekar N, Jasti S, Yung AWK, Ali-Osman F, Kyritsis AP, Nicolson GL, Rao JS, Mohanam S. Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. Clin. Expl. Metastasis, 2001;18:337–42.
[75] Nicolson GL, Nawa A, Sawada H, Toh Y, Taniguchi S, Nishimori K. Tumor metastasis-associated human MTA1 gene: role in epithelial cell proflieration and regulation. In: Cancer Metastasis--related Genes, D Welch, ed., Kluwer Publishers, Amsterdam, 2001:51–63.
[76] Nicolson GL, Nasralla MY. Advantages and limitations of models for cancer and malignant cell progression. In: Cancer Handbook, M Alison, ed., Macmillan Publishers, London, 2001;863–72.
[77] Konduri SD, Tasiou A, Chandrasekar N, Nicolson GL, Rao JS. Role of Tissue Factor Pathway Inhbitor-2 in amelanotic melanoma (C-32) invasion. Clin. Expl. Metastasis, 2001;18:303–8.
[78] Haier J, Nicolson GL. Tumor cell adhesion under hydrodynamic conditions of fluid flow. Acta Pathol Microbiol. Infect. Scand, 2001; 109:241–62.
[79] Nicolson GL, Berns P. Tracking down a treatable cause of Chronic Fatigue Syndrome [Letter]. Consultant Prim. Care, 2001;41:168–9.
[80] Nicolson GL. Gulf War Illnesses—Causes and Treatments. Armed Forces Med. Develop, 2001;2:41–4.
[81] Nicolson GL, Ngwenya R. Dietary considerations for patients with chronic illnesses and multiple chronic infections. A brief outline of eighteen dietary steps to better health. Townsend Lett. Doctors, 2001;219:62–5.
[82] Nicolson GL. Gulf War illnesses—their causes and new treatments. Emerg. Resp. Disaster Manag, 2001;3:41–4.
[83] Haier J, Nicolson GL. Hematological malignancies in cancer research. In: Cancer Handbook, M Alison, ed., Macmillan Publishers, London, 2001:1101–14.
[84] Cavanaugh PG, Nicolson GL. Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastatic cell lines: identification as an active subunit of arginase. Clin. Expl. Metastasis, 2001;18:509–18.
[85] Nicolson GL. Protection from bioterror and biological warfare agents. Towsend Lett. Doctors, 2001;221:62–7.
[86] Haier J, Nicolson GL. Cell surface molecules as indicators of prognosis in colorectal carcinomas. New Surg, 2001;1:152–7.
[87] De Meirleir K, De Becker P, Nijs J, Perterson DL, Nicolson GL, Patarca-Montero R, Englebienne P. CFS etiology, the immune system and infection. In: Chronic Fatigue Syndrome: a Biological Approach. K Meirleir, P Englebienne, eds., CRC Press, New York, 2002:201–28.
[88] Nicolson GL, Nasralla M, Haier J, Pomfret J. High frequency of systemic mycoplasmal infections in Gulf War veterans and civilians with Amytrophic Lateral Sclerosis (ALS). J. Clin. Neurosci, 2002;9:525–9.
[89] Nicolson GL. Autocrine and paracrine growth mechanisms in cancer progression and metastasis. In: Encyclopedia of Cancer, JR Bertino, ed., 2nd Edition, Academic Press, San Diego, 2002;1:165–77.
[90] Nicolson GL. Bioterror and biological warfare agents—A brief summary. Emerg. Resp. Disas. Manag, 2002;4:61–6.
[91] Nijs J, Nicolson GL, De Becker P, Coomans D, De Meirleir K. High prevalence of mycoplasmal infections among European Chronic Fatigue Syndrome patients. Examination of four Mycoplasma species in Chronic Fatigue Syndrome patients. FEMS Immunol. Med. Microbiol, 2002;34:209–14.
[92] Haier J, Nicolson GL. PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow. Oncogene, 2002;21:1450–60.
[93] Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K. Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin. Expl. Metastasis, 2002;20:14–9.
[94] Nicolson GL, Nasralla M, De Meirleir K, Haier J. Bacterial and viral co-infections in Chronic Fatigue Syndrome (CFS/ME) patients. In: Clinical and Scientific Aspects of Myalgic Encepthalopathy/Chronic Fatigue Syndrome, the Practitioners Challenge, Alison Hunter Foundation, Sydney, Australia, 2002:27–34.
[95] Haier J, Gallick GE, Nicolson GL. Src protein kinase pp60c-src influences adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow J. Exp. Therapeutics Oncol, 2002;2:237–46.
[96] Nass M, Nicolson GL. Anthrax vaccine: historical perspective and current controversy. J. Nut. Environ. Med, 2002;14(4):277–86.
[97] Nigs J, De Meirleir K, Coomans D, De Becker P, Nicolson GL. Associations between mycoplasmae and 2.5A synthetase RNase L antiviral pathway in Chronic Fatigue Syndrome. In: Clinical and Scientific Aspects of Myalgic Encepthalopathy/Chronic Fatigue Syndrome, the Practitioners Challenge, Alison Hunter Foundation, Sydney, Australia, 2002; 43–8.
[98] Nigs J, Nicolson GL, De Becker P, De Meirleir K. Prevalence of mycoplasmal infections among Belgium CFS patients. In: Clinical and Scientific Aspects of Myalgic Encepthalopathy/Chronic Fatigue Syndrome, the Practitioners Challenge, Alison Hunter Foundation, Sydney, Australia, 2002:179–80.
[99] De Meirlier K, De Becker P, Nijs J, Peterson DL, Nicolson GL, Patarca-Montero R, Englebienne P. CFS etiology, the immune system, and infection. In: Chronic Fatigue Syndrome: A biological approach, P. Englebienne, K De Meirlier, eds., CRC Press, Boca Raton, 2002:201–28.
[100] Nicolson GL, Berns P, Nasralla M, Haier J, Nicolson NL, Nass M. Gulf War Illnesses: chemical, radiological and biological exposures resulting in chronic fatiguing illnesses can be identified and treated. J. Chronic Fatigue Syndr. 11(1):135–54 (2003).
[101] Nicolson GL, Nasralla M, Gan R, Haier J, De Meirleir K. Evidence for bacterial (Mycoplasma, Chlamydia) and viral (HHV-6) co-infections in chronic fatigue syndrome patients. J. Chronic Fatigue Syndr, 2003; 11(2):7–20.
[102] Nicolson GL, Nasralla M, Nicolson NL, Haier J. High prevalence of mycoplasmal infections in symptomatic (Chronic Fatigue Syndrome) family members of mycoplasma-positive Gulf War Illness patients. J. Chronic Fatigue Syndr. 11(2): 21–36 (2003).
[103] Nijs J, De Meirleir K, Coomans D, De Becker P, Nicolson GL. Deregulation of the 2.5A synthetase RNase L antiviral pathway by mycoplasmas in subsets of Chronic Fatigue Syndrome. J. Chronic Fatigue Syndr, 2003;11(2):37–50.
[104] Nijs J, De Meirlier K, Coomans D, De Becker P, Nicolson GL. Immunophenotyping predictive of mycoplasma infection in patients with chronic fatigue Syndrome. J. Chronic Fatigue Syndr,2003;11(2):51–70.
[105] Nicolson GL, Gan R, Haier J. Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. Acta Pathol. Microbiol. Immunol. Scand, 2003;111: 557–66.
[106] Ellithorpe RR, Settineri R, Nicolson GL. Pilot Study: Reduction of fatigue by use of a dietary supplement containing glycophospholipids. J. Am. Nutraceut. Assoc, 2003; 6:23–8.
[107] Nicolson GL. Chronic fatigue, aging, mitochondrial function and nutritional supplements. Townsend Letter Doctors, 2003;240:72–6.
[108] Yanamandra N, Berhow MA, Konduri S, Dinh DH, Olivero WC, Nicolson GL, Rao JS. Triterpenoids from Glycine max decrease invasiveness and induce caspase-mediated cell death in human SNB19 glioma cells. Clin. Expl. Metastasis, 2003;20:375–83.
[109] Nicolson GL. Lipid replacement as an adjunct therapy in chronic fatigue, anti-aging and restoration of mitochondrial function. J. Am. Nutraceut. Assoc, 2003;6(3):22–8.
[110] Agadjanyan M, Vasilevko V, Ghochikyan A, Berns P, Kesslak P, Settineri RA, Nicolson GL. Nutritional supplement (NT Factor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects. J. Chronic Fatigue Syndr, 2003;11(3):23–36.
[111] Vasilevko V, Ghochikyan A, Sadzikava N, Petrushina I, Tran M, Cohen, EP, Kesslak PJ, Cribbs DH, Nicolson GL, Agadjanyan MG. Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of syngenic mouse mammary tumors. Clin. Expl. Metastasis, 2003;20:489–98.
[112] Nicolson GL. Lipid replacement/antioxidant therapy for anti-aging, fatigue and restoration of mitochondrial function. AgroFood High Tech, 2004;16(3):20–3.
[113] Nicolson GL, Gan R, Haier J. Evidence for Brucella spp. and Mycoplasma spp. co-infections in the blood of chronic fatigue syndrome patients. J. Chronic Fatigue Syndr. 12: in press, 2004.
[114] Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, Okamura T, Nicolson GL. Expression of the metastasis-associated MTA1 protein and its relationship to deacylation of the histone H4 in esophageal squamous cell carcinomas. Int. J. Cancer, 2004;110:362–7.
[115] von Sengbusch A, Gassmann P, Fisch K, Nicolson GL, Haier J. Focal adhesion kinase regulates dynamic adhesion of carcinoma cells to collagens. Am. J. Pathol, in press, 2004.
[116] Nicolson GL. Transfilter cell invasion assays. In: Cell Biology: A Laboratory Handbook, 3rd Edition, JE Celis, ed., Academic Press, New York, in press, 2004.
[117] Nigs J, Nicolson GL Gulf War veterans: Evidence for chromosomal alterations and their significance. J. Chronic Fatigue Syndr, 2004; 12(1):7 9–83.
[118] Gassmann P, Haier J, Nicolson GL. Cell adhesion and invasion during secondary tumor formation. In: Cancer Growth and Progression, vol. 3, Kluwer, Amsterdam, in press, 2004.
[119] Nicolson GL, Ellithrope R. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. J. Chronic Fatigue Syndr. 12: in press, 2004.
Books and Monographs Edited
[1] Nicolson GL, Raftery MA, Rodbell M, Fox CF, eds. Cell Surface Receptors, Vol. 8 of Prog. Clin. Biol. Res., Alan R. Liss, Inc., New York (1976), 396 pp.
[2] Poste G, Nicolson GL, eds. The Cell Surface in Animal Embyrogenesis and Development, Elsevier, North-Holland, Amsterdam (1976), 766 pp.
[3] Poste G, Nicolson GL, eds. Virus Infection and the Cell Surface, Elsevier, North-Holland, Amsterdam (1976), 442 pp.
[4] Poste G, Nicolson GL, eds. Dynamic aspects of Cell Surface Organization, Elsevier, North-Holland, Amsterdam (1977), 744 pp.
[5] Poste G, Nicolson GL, eds. Membrane Assembly and Turnover, Elsevier, North-Holland, New York (1977), 883 pp.
[6] Poste G, Nicolson GL, eds. Membrane Fusion, Elsevier, North-Holland, New York (1978), 863 pp.
[7] Cotman C, Poste G, Nicolson GL, eds. The Cell Surface and Neuronal Function, Elsevier, North-Holland, Amsterdam (1980), 546 pp.
[8] Poste G, Nicolson GL, eds. Cytoskeletal Elements and Plasma Membrane Organization, Elsevier, North-Holland, Amsterdam (1981), 349 pp.
[9] Poste G, Nicolson GL, eds. Membrane Reconstitution, Elsevier, New York (1982), 273 pp.
[10] Moloy P, Nicolson GL, eds. Cellular Oncology: New Approaches in Biology, Diagnosis and Treatment, Praeger, New York (l983) 305 pp.
[11] Nicolson GL, Milas L, eds. Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects, Raven Press, New York (1984), 481 pp.
[12] Moloy P, Nicolson GL, eds. Regional Nodal Metastasis: Biology, Diagnosis and Treatment, Praeger Press, New York (1987), 256 pp.
[13] Nicolson GL, Fidler IJ, eds. Tumor Progression and Metastasis, Alan R. Liss, New York (1988), 302 pp.
[14] Skouteris G, Nicolson GL, eds. Intramolecular Cross-talk in Metastasis, NATO ASI series, IOS Press, Amsterdam, (1999), 309 pp.
Editor (United Kingdom)
Michel Odent, MD
Michel Odent was born in France in 1930. He studied Medicine in Paris and was originally educated in the 1950s as a surgeon. In 1958-1959, during the independence war in Algeria, he was in the French army, practicing war surgery and civilian emergency surgery. It is via the caesarean section that he developed his interest for birth physiology and became an obstetrician. He is familiarly known as the obstetrician who introduced in a state general hospital—in the 1970s—the concepts of birthing pools and home-like birthing rooms.
After his hospital career he practiced home birth and founded the Primal Health Research Centre in London (UK), whose objective is to study the long-term consequences of early experiences. The Primal Health Research data bank can be explored on the web (www.birthworks.org/primalhealth).
He recently developed a preconceptional program to minimize the effects of intrauterine and milk pollutions by synthetic fat soluble chemicals such as dioxins, PCBs, etc. Author of more than 50 papers in the medical literature and 12 books published in 21 languages. The Scientification of Love, The Farmer and the Obstetrician, and The Caesarean are his latest published books.
Editor (India)
Yash Paul, MB BS, DCH
Yash Paul was born on March 13, 1937 in Gujranwalla, which is now a part of Pakistan. His early education occurred in Karachi, which is also now a part of Pakistan and Delhi, the capital of India. He received his M.B. B.S. medical degree in 1961 from S.M.S. Medical College, Jaipur and D.C.H. in 1963 from M.G.M. Medical College, Indore. Dr. Yash Paul joined Rajasthan Medical Services in 1963. From 1969 to 1975 he served as Lecturer in Pediatrics in various Medical Colleges in Rajasthan. He worked in Children’s Hospital, Tripoli, Libya from November 1975 to March 1980. In 1982 he took voluntary retirement from the service and currently practices as a Consultant Pediatrician in Jaipur.
Dr. Yash Paul has three daughters, two of whom serve as medical doctors. One is a gynecologist married to a pediatrician and the other is a pediatrician, all practice in Jaipur.
Dr. Yash Paul published his first medical article in 1972 in the Indian Journal of Pediatrics. Many subsequent articles and letters have been published in Academy Today (a bulletin of the Indian Academy of Pediatrics), Indian Journal of Practical Pediatrics, Indian Pediatrics, Indian Journal of Pediatrics, Indian Journal of Medical Microbiology, Indian Journal of Gastroenterology, Indian Journal of Medical Ethics, Indian Journal of Community Medicine, Bioethics, Medical Veritas, Asian Journal of Paediatric Practice, The Antiseptic, British Medical Journal-South Asia Edition, and Vaccine.
Dr. Yash Paul has defined the distinction between herd immunity and herd protection provided by the vaccines [57]. Dr. Yash Paul has also described a method whereby liver borders can be localized clinically by auscultation and not by percussion method as is the current practice [69].
Publications
[1] Paul Y. Face of the child as an index of disease. Indian J Pediatr, 1972; 39:76–83.
[2] Paul Y. Examination of the Newborn I. Indian J Pediatr 1973;40:69–78.
[3] Paul Y. Examination of the Newborn II. Indian J Pediatr 1973;40:114–23
[4] Paul Y. Examination of the Newborn III. Indian J Pediatr 1973;40:156–66.
[5] Paul Y. Incidence of Mitral Valve Prolopse in Children Indian Pediatr 1992;29:1175.
[6] Paul Y. Immunization practices amongst pediatricians: a postal survey. Indian Pediatr 1994;31:949–55.
[7] Paul Y, Singh J. Cutaneous larva migrans in an infant. Indian Pediatr, 1994;31:1089–91.
[8] Paul Y. Undigested food presenting as bizarre objects in stool. Indian Pediatr 1994;31:1130–1.
[9] Paul Y. The liver: enlarged or pushed down? Indian J Pediatr 1995; 65:127–8.
[10] Paul Y. Can BCG be given along with DPT and Polio? Indian Pediatr 1995;32:699.
[11] Paul Y. Does BCG immunization prevent tuberculosis? Indian Pediatr 1995;32:1135.
[12] Paul Y. Iron deficiency anemia in pregnancy. Indian Pediatr, 1996; 33:969.
[13] Paul Y. Baby Friendly Hospital. Indian Pediatr, 1997;34:749.
[14] Paul Y. Should we revise the Primary Immunization Schedule? Indian Pediatr, 1997;34:839.
[15] Paul Y. A cheap alternative to a stadiometer and infantometer. Indian Pediatr, 1997;34:949.
[16] Paul Y. secret of examination of a newborn. IAP Journal of Practical Pediatrics, 1997;5:253
[17] Paul Y. Loperamide: Is it harmful? IAP Journal of Practical Pediatrics 1998; 6:79.
[18] Paul Y. Safe vaccines. IAP Journal of Practical Pediatrics, 1998;6:277.
[19] Paul Y. Right age for Meningococal vaccine. Indian Pediatr, 1998;35:669.
[20] Paul Y. Immunization against Tentanus. Indian Pediatr, 1998;35:477.
[21] Paul Y. The making of a pediatrician. Indian Pediatr, 1998;35:479.
[22] Paul Y. Baby born to a mother with tuberculosis. Indian Pediatr, 1998; 35:491.
[23] Paul Y. BCG vaccination with antitubercular therapy. Indian Pediatr, 1998;35:493.
[24] Paul Y. The Updates are for the audience. Indian Pediatr, 1998;35:571.
[25] Paul Y. Interval between immunization sessions. Indian Pediatr, 1998; 35:1029.
[26] Paul Y. Role of DPT or TT vaccines after injury as prophylaxis. Indian Pediatr, 1999;36:198–9.
[27] Paul Y. Need of Rabies Vaccine After a Course of Rabies Vaccination. Indian Pediatr, 1999;36:199.
[28] Paul Y. Contraindications of OPV. Indian Pediatr, 1999;36:318–9.
[29] Paul Y. HIV infection and tuberculosis. Indian ediatr, 1999;36:431.
[30] Paul Y. Pacifiers, feeding bottles and the pleasure of sucking. Indian J Pract Pediatr, 1999;1:205
[31] Paul Y. Should a sick child be immunized? Indian Pediatr 1999;36:837–8.
[32] Paul Y. Polio virus isolates from AFP cases. Indian Pediatr 1999; 36:1061.
[33] Paul Y. Pulse polio campaign. Indian Pediatr, 1999;36:1064–5.
[34] Paul Y. How to avoid multiple injections? Indian Pediatr, 1999;36:1168.
[35] Paul Y. Should Hib vaccine be given priority over Hepatitis B vaccine? Indian Pediatr, 2000;37:105.
[36] Paul Y. Is Hepatitis B immunization necessary for all? Indian J Pract Pediatr, 2000;2:188.
[37] Paul Y. Safeguard against tuberculosis for children in schools. Indian Pediatr, 2000; 37:446.
[38] Paul Y. HIV infection and immunization. Indian Pediatr, 2000;37:559.
[39] Paul Y. Should Tetanus Toxoid be administered every 5 years? Indian Pediatr, 2000; 37:795.
[40] Paul Y. Polio eradication strategy: need for re-appriasal. Indian Pediatr, 2000; 37:913–6.
[41 ] Paul Y. Polio eradication strategy: need for re-appraisal (Reply). Indian Pediatr, 2000; 37:1396–400.
[42] Paul Y. Age limit for polio vaccine. Indian Pediatr, 2000;37:906.
[43] Paul Y. Which is optional vaccine. Indian Pediatr, 2001;38:99.
[44] Paul Y. Medical negligence and vaccine associated paralytic poliomyelitis. Indian Pediatr, 2001;38:1068.
[45] Paul Y. Risk factors for recurrence of febrile convalrious. Indian Pediatr, 2001;38:1433.
[46] Paul Y. How do the vaccine polio viruses replace the wild polio viruses? Indian J Med Microbiology, 2002;20:56.
[47] Paul Y. Hepatitis B immunization schedule recommended by IAP. Indian Pediatr, 2002;39:503–4.
[48] Paul Y. SSPE and Measles Vaccine. Indian J Med Microbiology, 2002; 20:226.
[49] Paul Y. Accuracy of the National Polio Surveillance Project Data in Rajasthan. Indian J Pediatr, 2002; 69:667–73.
[50] Paul Y. Are we teaching some wrong facts pertaining to Oral Polio Vaccine? Indian J Pediatr, 2002; 69:1101–2.
[51] Paul Y. Economical way to control typhoid infections in South Asia. BMJ-South Asia Edition, 2002;18:217.
[52] Paul Y. An inexpensive but effective breathing exercise appliance for children. BMJ-South Asia Edition, 2002;18:787.
[53] Paul Y. The making of a polio free India. Indian J Pediatr, 2003;70:113–4.
[54] Paul Y. Impact of daily versus weekly hematinics supplementation on anemia in pregnancy. Indian Pediatr, 2003;40:273.
[55] Paul Y. Can Polio be eradicated from India through present Polio Eradication Program? BMJ-South Asia Edition, 2003;19:499–501.
[56] Paul Y. Polio eradication in India. Indian Pediatr, 2003; 40:1100–1.
[57] Paul Y. Herd immunity and herd protection. Vaccine, 2004;22:301–2.
[58] Paul Y. Why have we failed to eradicate polio from India? Medical Veritas, 2004;1(1):1–3.
[59] Paul Y. Misinformation regarding National Polio Surveillance Project Data in Rajasthan (Reply) Indian J Pediatrics 2003;70:684.
[60] Paul Y. Set back in polio eradication in 2002: reasons and remedies. Indian Pediatr, 2004;41:202–3.
[61] Paul Y. Need for re-appraisal of acute flaccid paralysis (AFP) case classification. Vaccine, 2004;22:3829–30.
[62] Paul Y, Priya. Polio eradication in India: some observations. Vaccine 2004;22:4144–8.
[63] Paul Y. Herd immunity redefined. The Antisaptic, 2004;101:242.
[64] Paul Y, Priya. What does India need—superspecialists or general pediatricians? Asian J Paediatric Practice, 2004;8:22–4, 31–2.
[65] Paul Y, Priya. Doctor’s dilemma: which vaccines to recommend? The Antiseptic, 2004;101:524–5.
[66] Paul Y. Red Cross Emblem. BMJ-South Asia Edition, 2004;20:497.
[67] Paul Y. Polio Eradication: A Mirage? Indian J Clinical Practice, 2004; 15(7):41–4.
[68] Paul Y. Probiotics in diarrhea: to prescribe or not to prescribe. The Antiseptic, 2005;102:52.
[69] Paul Y. Localisation of the liver borders by auscultation to measure the liver span. Indian J Gastroentrology, 2004;23:193–4.
[70] Paul Y. Polio eradication: let us face the facts and accept the reality. Indian Pediatr, 2005;42:728–9.
[71] Paul Y. Evaouation of OPV efficacy is required for polio eradication in India. Vaccine, 2005;23:3097–8.
[72] Paul Y. Compassion for the animals, no concern for the children. Vaccine 2004;23:280.
[73] Paul Y. Dawson A. Some ethical issues arising from polio eradication programme in India. Bioethics 2005;19:393–406.
[74] Paul Y. Avoidance of food allergens in asthmatics. Indian Pediatr 2005;42:964.
[75] Paul Y. Polio eradication programme: some ethical issues. Indian J Medical Ethics, 2005;2:115–6.
[76] Paul Y, Dawson A. Some ethical issues arising from polio eradication programmes in India. Bioethics, 2005;19:393–406.
[77] Paul Y. Some exaggerated or non-existing properties of OPV. Indian J Community Medicine 2005;30:152.
[78] Paul Y. Polio eradication: experts have misled us. Medical Veritas, 2006;3(1):781–5.
Books and Chapters
[1] Paul Y. A Manual of Examination of the Newborn. London: William Heinemann Medical Books Ltd. 1976.
[2] Paul Y. Essentials of Immunizations: Guidelines for Parents. 1997.
[3] Paul Y, Priya. Current Controversies in Immunization. In: Gupte S, ed. Recent Advances in Pediatrics, Special Volume 11, Community Pediatrics. New Delhi, India: Jaypee Brothers, 2002;65–86.
[4] Paul Y, Singh J Immunization and seizure Disorders. In: Mathur GP, Mathur S, eds. Seizures in Children and Adolescents. New Delhi India: Academa Publishers, 2005;138–40.
[5] Paul Y, Marwah P. Immunization in Adolescents. In: Recent Advances in Pediatrics, Gupte S, ed., Special Vol. 17, Adolescents. New Delhi, India: Jaypee Brothers, 2006:356–70
Senior Editor (Australia)
Michael K. Primero, BSc, MScSoc
Michael K. Primero was born in Sydney, Australia, in 1966. He attended the University of New South Wales from which he received a Bachelor of Science (B.Sc.) in Psychology and a Master’s Degree in Science and Technology Studies (M.Sc.Soc.) in 1996. For the Master’s degree he wrote a treatise on ‘HIV dissidents’ (namely, experts and others who consider that AIDS is not caused by “HIV”) in the context of the concerns of partisanship and commitment of the sociological analyst of science.
Michael K. Primero believes that the arena of medicine is most appropriately studied via research methodologies that clearly acknowledge the contingent and socially negotiated nature of the science of medicine. In accordance with this stance, many of the topics of dissent to modern medical research and practice can be best understood and addressed when we advance from a limited positivistic framework of the understanding of science, which almost inevitably employs an obfuscating “rhetoric of objectivity" that fails to acknowledge social interests. Considering the effect of the social on the very formation of medical scientific knowledge leads us to the potential for reconstructions of medical science and practice that embody more socially just ideals.
Michael K. Primero’s interests also include consumercide, a word he coined to denote the impact that consumer society has in contributing toward unhealthy environments. His website devoted to this topic (www.consumercide.com) is a diverse array of materials concerned with medical, social, psychological and environmental issues, presenting dissident or marginalised but potentially valuable concepts for these arenas of common concern.
Michael K. Primero is presently involved in studies leading towards a Ph.D. in Science and Technology Studies. He is engaged in research that includes the socio-political analysis of controversies surrounding the science of vaccination.
Editor (Kansas, United States)
Walter R. Schumm, PhD
Walter R. Schumm is married and has seven children. He received a B.S. in Physics and was awarded an M.S. degree in Family and Child Development in 1976 from Kansas State University. In 1979 he earned a Ph.D. from Purdue University. From 1990 to the present he has served as Professor in the School of Family Studies and Human Services, Kansas State University.
Dr. Schumm is affiliated with the following professional affiliations: the National Council on Family Relations (NCFR), American Home Economics Association (AHEA), Omicron Nu (Home Economics), Phi Upsilon Omicron (Home Economics), Gamma Sigma Delta (Agriculture), and the Society for the Scientific Study of Religion (SSSR)
In 1987 Dr. Schumm was certified as a Professional Home Economist by the American Home Economics Association and as a Family Life Educator by the National Council on Family Relations. In 1990 he was recipient of the MORAN Resarch Excellence Award from the American Home Economics Association. In 1997, he received the Dawley-Scholer Faculty Research Excellence Award by the College of Human Ecology, Kansas State University.
Dr. Schumm currently serves as a manuscript reviewer for American Journal of Epidemiology, Psychological Reports, Journal of Psychology and Theology, Family Relations, Journal of Applied Developmental Psychology, Marriage and Family Review, Journal of Teaching Marriage and Family, Journal of Rehabilitation Research and Development, Journal of Marriage and the Family, and the Journal of Family Issues.
Dr. Walter R. Schumm is credited with the publication of over 200 articles, chapters, book reviews, or handbooks in areas concerning (1) family theory, research methodology, (2) military family and health research, and (3) other topics.
In the area of family theory, research methodology, the Sourcebook of Family Theories and Methods by Boss, Doherty, LaRossa, Schumm, & Steinmetz [1] has been the standard volume on theory and research in the field of family studies for the past decade; it sold over 25,000 copies despite it high cost and over 900 page length. Schumm [2] represents a summarization of five different two dimensional family theory models, derived from over 20 years of teaching family theory, including an elaboration of the family strengths model first presented in Schumm [3]. Schumm [4], an invited paper keyed to Schumm’s extensive research on satisfaction in families, represents an integration of pleasure, happiness, satisfaction, and joy as four distinct but interrelated aspects of positive affect. Schumm [5], Schumm [6], Schumm & Bugaighis [7], and Schumm & Kirn [8] all represent Schumm’s expanding application of social exchange and equity theories to difficult and controversial aspects of close relationships.
In the area of family measurement research, Akagi et al. [9] and Schumm et al. [10] represent the continuing pursuit of further evaluation and development of the Kansas Marital Satisfaction Scale, observed by Sabatelli [11] to be one of the most valid brief measures of marital quality in the field. Schumm & Hemesath [12] is the most recent summary and integration of family measurement research published over the past ten years in the family field. Schumm [13, 14] in the Handbook of Family Measurement, a Behavioral Book Club selection, helped earn the author the 1990 Moran Memorial Research Award (Best Scientist of the Year) from the American Home Economics Association, now the American Association of Family and Consumer Science.
In the area of data analysis, including research methodology, scholarship of teaching, and critiques, Schumm et al. [15] represents a culmination of Schumm’s scholarship of learning with respect to student learning objectives for research methodology and statistics as applied in the family field. Acock & Schumm [16] has remained one of the key papers on the use of multivariate statistical methods in the family area. Schumm [17] and Schumm et al. [18] were cited for many years past their publication date because of their success at integrating measurement, data analysis, and theory in the family research process, something few papers had done previously. Schumm [19] represents only the most recent example in which Schumm observed a scholar publishing material that revealed an ignorance of the linkage between theory, measurement, and analysis, with the result having been the acceptance of conclusions that were, in fact, entirely erroneous. When the author of that published paper was asked to reanalyze his data, he avoided the issue by reporting that he had “lost” his data (the same year he had published it).
In the area of program evaluation research, including evaluations of premarital education and counseling programs, Silliman & Schumm [20, 21], as well as Schumm & Denton [22], are widely cited because of their comprehensive review of the premarital education and counseling literature over a period of 20 years. Schumm’s numerous articles in the program evaluation area serve his students well when they take FSHS 893, Program Evaluation, from Dr. Schumm. Schumm’s articles with Turek and others [23, 24, 25] represent some very rare published field research with Reserve Component units with respect to the assessment of their training programs.
In the area of military family and health research, Schumm and his colleagues [26] have been the first ever to publish data that supports the hypothesis that overseas deployments are associated with increases in divorce rates among U.S. military personnel, overturning years of Department of Defense arguments to the contrary. They have also published many of the best recent reports on what the military needs to do to support its families [27, 28], including papers published internationally [29].
Schumm and his students have published several reports on vaccines [30, 31] and pyridostigmine bromide pills [32] as possible causes of Gulf War illness; recently, the Government Accounting Office (GAO) itself released a report (GAO, 2002) which cited Schumm et al. [30] as evidence that anthrax vaccine was a cause of Gulf War illness. Lea Steele, who headed up Gulf War research in Kansas under the Kansas Commission on Veterans Affairs and now heads up a national committee on Gulf War issues from her office at the VA Medical Center in Topeka, stated recently (October, 2003) that Schumm’s Gulf War research is being cited more and more frequently in medical articles on the topic. Most recently, Schumm and others have published research on organizational commitment in the military and its consequences. The only recent summary of what is known about humane treatment in prisoner of war operations was published by Schumm et al. [33]. Also a bit ahead of its time, another report by Schumm et al. [34] investigated the prospective attitudes of reservists if the military were to change its policy of mobilization frequency and begin asking reservists to accept frequent, year long mobilizations as part of their normal reserve career.
In the area of marital/family outcomes (interaction and satisfaction), Silliman, Schumm, et al. [35] recently provided the field with an integration of what is known about marital satisfaction as it relates to the prevention of marital problems. In a variety of reports, the most recent being Schumm, Webb, and Bollman [36], Schumm has tested the Jessie Bernard (1972) hypothesis of the “his and hers” marriage, finding that her view is correct for a minority of marriages, even though gender main effect sizes are typically rather small (0.10). Gwanfogbe, Schumm, et al. [37] was one of very few recent papers to evaluate marital satisfaction and life satisfaction across monogamous and polygamous marriages. Schumm’s research experience in the areas of family communication, family violence, gender roles, marital quality, family life cycle issues, child discipline, and other topics serves well in his graduate teaching of the courses Marital Interaction (FSHS 862) and Family Studies (FSHS 850).
[1] Boss PB, Doherty W, LaRossa R, Schumm WR, Steinmetz S. (eds.) Sourcebook of family theories and methods: a contextual approach. New York: Plenum, 1993
[2] Schumm WR. Comments on marriage in contemporary culture: five models that might help families. Journal of Psychology and Theology, 2003; 31: 213–23.
[3] Schumm WR. Beyond relationship characteristics of strong families: constructing a model of family strengths. Family Perspective, 1995;19(1):1–9. Reprinted (in part): Larson LE, Goltz JW, Hobart CW. Families in Canada: social context, continuities, and changes. Scarborough, Ontario: Prentice-Hall, Canada, 1993
[4] Schumm WR. Satisfaction. Selection, In: D Levinson, JJ Ponzetti, Jr., PF Jorgensen (eds.), Encyclopedia of Human Emotions. (Volume 2). New York: MacMillan References, 1999:583–90.
[5] Schumm WR, Ripley J. (In press) Book review of John M. Gottman’s The Mathematics of Marriage. Journal of Sex Research.
[6] Schumm WR. Feminism and family studies: another viewpoint. Journal of Family Issues, 1987; 8:253–56.
[7] Schumm WR, Bugaighis MA. Marital quality and marital stability: resolving a controversy. Journal of Divorce, 1985;9(1):73–7.
[8] Schumm WR, Kirn JE. Evaluating equity in the marital relationship: An alternative approach. Psychological Reports, 1982;51:759–62.
[9] Akagi CA, Schumm WR, Bergen MB. Dimensionality of the Kansas Family strengths Scale and the Kansas Marital Satisfaction Scale as revised to capture changes in marital satisfaction. Psychological Reports, 2003;93:1267–74.
[10] Schumm WR, Bollman SR, Jurich AP, Hatch RC. Family strengths and the Kansas Marital Satisfaction Scale: a factor analytic study. Psychological Reports, 2001;88:965–73.
[11] Sabatelli RM. Measurement issues in marital research: a review and critique of contemporary survey instruments. Journal of Marriage and the Family, 1988;50:891–915.
[12] Schumm WR, Hemesath KK. Measurement in family studies. In: M Sussman, SK Steinmetz, G Peterson (eds.), Handbook of Marriage and the Family, New York: Plenum, 1999:291–305.
[13] Schumm WR. Evolution of the family field: measurement principles and techniques. In: J Touliatos, BF Perlmutter, MA Straus (eds.), Handbook of Family Measurement Techniques, Newbury Park , CA: Sage, 1990:23–6.
[14] Schumm WR Intimacy and family values. In: J Touliatos, BF Perlmutter, & M. A. Straus (eds.), Handbook of Family Measurement Technniques, Newbury Park, CA: Sage, 1990:164–79.
[15] Schumm WR, Webb FJ, Castelo CC, Akagi CA, Jensen EJ, Ditto RM, Spencer-Carver E, Brown B. Enhancing learning in statistics classes through the use of concrete historical examples. Teaching Sociology, 2002;30:361–75.
[16] Acock AC, Schumm WR. Analysis of covariance structures applied to family research and theory. In: PB Boss, W Doherty, R LaRossa, WR Schumm, SK Steinmetz (eds.), Sourcebook of Family Theories and Methods: A Contextual Approach, New York: Plenum, 1993:451–68.
[17] Schumm WR. Integrating theory, measurement, and statistical analysis in family studies survey research. Journal of Marriage and the Family, 1982;44:983–98.
[18] Schumm WR, Southerly WT, Figley CR. Stumbling block or steppingstone: path analysis in family studies. Journal of Marriage and the Family, 1980;42:251–62.
[19] Schumm WR. A reanalysis of Price’s ‘Islam and human rights: a case of deceptive first appearances.’” Psychological Reports, 2003;93:1335–8.
[20] Silliman B, Schumm WR. Marriage preparation programs: a literature review. The Family Journal, 2000;8:133–42.
[21] Silliman B, Schumm WR. Improving practice in marriage preparation. Journal of Sex & Marital Therapy, 1999;25:23–43.
[22] Schumm WR, Denton W. Trends in premarital counseling. Journal of Marital and Family Therapy, 1979;5(4): 23–32.
[23] Schumm WR, Turek DE. Distance-learning: first CAS3 class outcomes. Military Review, 2003;83(5):66–70.
[24] Schumm WR, Turek DE, Jones KD. Comparing learning environments in U.S. military officer educational settings: a field test. Psychological Reports, 2003;92:1131–2.
[25] Schumm WR, Turek DE, McCarthy D. Evaluating an all-ranks military staff ride. Psychological Reports, 2003;93:1156–8.
[26] Schumm WR, Bell DB, Gade PA. Effects of a military overseas peacekeeping deployment on marital quality, satisfaction, and stability. Psychological Reports, 2000;87:815–21.
[27] Bell DB, Schumm WR. Providing family support during military deployments. In: JA Martin, LN Rosen, LR Sparacino (eds.), The Military Family. Westport, CT: Greenwood Publishing Company, 2000:139–52.
[28] Schumm WR, Bell DB, Segal MW, Milan LM. The Family Readiness Group (FRG) Leader’s Handbook. (Study Report 2000-02, April). Alexandria, VA.: U.S. Army Research Institute for the Behavioral and Social Sciences, 2000.
[29] Bell DB, Segal MW, Schumm WR. U.S. Army family support services and family experiences during overseas deployments. Kernvraag, 2000; 123:91-102.
[30] Schumm WR, Reppert EJ, Jurich AP, Bollman SR, Webb FJ, Castelo CS, Stever JC, Sanders D, Bonjour GN, Brown BFC, Hall CA, Owens BL, Krehbiel M, Deng L, Kaufman M. Self-reported changes in subjective health and anthrax vaccination as reported by over 900 Persian Gulf War era veterans. Psychological Reports, 2002;90:639–53.
[31] Schumm WR, Webb FJ, Jurich AP, Bollman SR. Comments on the Institute of Medicine’s 2002 report on the safety of anthrax vaccine. Psychological Reports, 2002:91:187–91.
[32] Schumm WR, Reppert EJ, Jurich AP, Bollman SR, Webb FJ, Castelo CS, Stever JC, Kaufman M, Deng L, Krehbiel M, Owens BL, Hall CA, Brown BFC, Lash JF, Fink CJ, Crow JR, Bonjour GN. Pyridostigmine bromide and the long-term subjective health status of a sample of over 700 male Reserve Component Gulf War era veterans. Psychological Reports, 2002; 90:707–21.
[33] Schumm WR, Polk BB, Bryan J, Fornataro F, Curry J. Treating prisoners humanely. Military Review, 1998;78:83–93.
[34] Schumm WR, Jurich AP, Stever JA, Sanders D, Castelo CS, Bollman SR Attitudes of Reserve Component servicemembers regarding the consequences of frequent overseas deployments. Psychological Reports, 1998; 83:983–9.
[35] Silliman B, Schumm WR, Parker R, Simons M. Marital satisfaction, adulthood. In: TP Gullotta, M Bloom (eds.), Encyclopedia of Primary Prevention and Health Promotion. New York: Kluwer Academic/Plenum, 2003:677–83.
[36] Schumm WR, Webb FJ, Bollman SR. Gender and marital satisfaction: data from the National Survey of Families and Households. Psychological Reports, 1998;83:319–27.
[37] Gwanfogbe PN, Schumm WR, Smith M, Furrow JL. Polygyny and marital/life satisfaction: an exploratory study from rural Cameroon. Journal of Comparative Family Studies, 1997;28:55–71.
Editor (New South Wales, Australia)
Viera Scheibner, PhD
Viera Scheibner was born March 27, 1935 in Bratislava (formerly Czechoslovakia, now Slovak Republic). Her parents were employed in Law Courts. She first married in 1954 and had two daughters. In 1953, Viera Scheibner studied medicine at the Medical Faculty of Jan Masaryk University in Brno. She changed to the Faculty of Natural Sciences of the same university, and in 1954 transferred to the Jan Amos Comenius University in Bratislava where she graduated in 1958. She was awarded a doctorate in Natural Sciences (RNDR) from the Jan Amos Comenius University in Bratislava in 1964. Dr. Scheibner served as Senior Associate Professor (Docent) in 1967. Thereafter, she served as a principal research scientist until her retirement from the Department of Mineral Resources in 1987.
In 1991, Dr. Scheibner presented some of the results of her findings from the Cotwatch breathing monitor to the Second Immunisation Conference in Canberra, Australia. In 1993, she authored the book entitled Vaccination which was subsequently translated into several languages. From 1996 to the present, she has prepared some 90 reports for Shaken Baby Syndrome (SBS) cases and/or vaccine injury compensation cases in the U.S., U.K., Germany, Iceland, Sweden, and Australia. Dr. Scheibner has also authored several books on adverse vaccination effects.
Since 1994, Dr. Scheibner has traveled extensively throughout Australia, Europe, United Kingdom, Republic of Ireland, Scandinavia, the U.S., and Canada, holding seminars on the dangers and ineffectiveness of vaccination, as documented by orthodox medical research, for parents and health and medical professionals
Dr. Scheibner perceives her task as that of liaising with pediatricians and other medical experts, and of evaluation of the scientific research dealing with vaccination issues in general—and more particularly, with mass vaccination of infants and children. She has gathered a solid, extensive and irrefutable block of scientific evidence documenting vaccines as ineffective in the prevention of diseases, and has time and again issued warnings about a variety of real dangers, including brain hemorrhages and other brain damage, retinal hemorrhages and other ophthalmological injuries, as well as vaccine fatalities. The biological mechanisms of these injries are principally immunological and toxic-chemical. Dr. Scheibner has analyzed medical records and results of medical tests of some babies adversely affected or killed by vaccination and has documented the damage by case examples of the same vaccine damage described in orthodox medical literature.
An additional major subject of Dr. Scheibner’s research includes immunological and other non-accidential injuries in babies who suffered medication (antibiotics and pain killers) and/or birth injuries. She has documented the damage (including death) by case examples of identical non-accidental injuries as a result of iatrogenic (physician caused) immune or other disorders as described in medical literature.
Employment
1958-1961: Lecturer at the Department of Geology and Palaeontology of Jan Amos Comenius University, Bratislava. Lectured in Biology and Micropalaeontology
1962-1967: Senior Lecturer at the Department of Geology and Palaeontology of Jan Amos Comenius University, Bratislava
1967-1968: Docent (equivalent to Senior Associate Professor) at the Department of Geology and Palaentology of Jan Amos Comenius University, Bratislava
1968-1987: Micropalaeontologist by the Geological Survey of New South Wales, Dept. of Mines (later, Dept. of Mineral Resources)
1971-1973: Research Scientist (Department of Mineral Resources)
1973-1976: Senior Research Scientist (Dept. of Mineral Resources)
1976-1978: Principal Research Scientist1, category I
1978-1981: Principal Research Scientist1, category II
1981-1987: Principal Research Scientist1, category III
1987: Retired from the Department of Mineral Resources
1Note: The pre-requisite for these appointments required “Demon-stration of a considerable world standing in one’s research speacialty.”
Research Interests
1958 First scientific paper in Micropalaeontology of the Cretaccous Sequences of the Carpathian Klippen Belt in Slovakia published while a student at the Jan Amos Comenius University in Bratislava
1958 to 1968 Published 35 scientific papers (and one monograph) dealing with the Cretaceous and Jurassic Foraminifera of the Carpathian Klippen Belt in Slovakia
1968 to 1987 Studied Cretaceous and Permian Foraminifera of the Great Australian Basin in New South Wales, and South Australian and the Carnarvon Basins in Western Australia; South Africa and the Indian Peninsula, and Permian Foraminifera of the Sydney Basin
1972 to 1976 Invited to participate in the highly prestigious Deep Sea Drilling Project (DSDP) conducted under the auspices of the Scripps Institution of Oceanography (U.S.A.), in the Atlantic and Indian Oceans; results of these studies are published in the Initial Reports of the DSDP; invited to write a Synopsis of Cretaceous Foraminifera of the Indian Ocean, published in amonograph entitled, Synopsis of the DSDP in the Indian Ocean
1993 Book published entitled, “Vaccination” (296 pp) based on an extensive study of vaccination issues as published in refereed medical journals; book has been published in German by Hirthammer Verlag, Dutch by Lemniscast Publishers, and Finnish by Kustantaja Lasse Vajaranta
1994 Produced a 2-hour video of lecture on the dangers and ineffectiveness of vaccination.
1994 Lectured for students of chiropractic at a number of chiropractic colleges in the U.S.A.
1995 Invited and accepted as an expert on vaccination and cot death by the College of Physicians Montreal, Canada; Dec. 11, 1995 gave evidence on the subject Vaccination and Cot Death before the Disciplinary Committee of the College of Physicians in Montreal, Canada as an expert for Dr. Guillaine Lanctot.
1996 to present Provided expert reports for court cases of vaccine injuries/deaths; prepared 90 reports for Shaken Baby Syndrome (SBS) cases and/or vaccine injury compensation cases in the U.S., U.K. Germany, Iceland, Sweden, and Australia.
1996 Invited to deliver luncheon talk on dangers and ineffec-tiveness of vaccination to the medical staff of the Research Hospital in Kansas City, MO.
1997 Delivered lecture entitled, Vaccination, yes or no? at seminar organized by a professional organization of Dutch medical doctors in Utrecht, Holland.
1996 to 1997 Several lectures at Chiropractic Colleges in the U.S.
1996 Participated in the Maroochydore (Queensland, Australia) hearing of the Equal Opportunity and Anti-discrimination Commission as an expert on the dangers and ineffectiveness of vaccination, and the link between vaccination and cot death.
1997 Delivered lecture entitled, Vaccination, yes or no? at seminar organized by a professional organization of Dutch medical doctors in Utrecht, Holland.
1996 to 1997 Several lectures at Chiropractic Colleges in the U.S.
1996 Participated in the Maroochydore (Queensland, Australia) hearing of the Equal Opportunity and Anti-discrimination Commission as an expert on the dangers and ineffectiveness of vacci nation, and the link between vaccination and cot death.
1997 Invited by the Faculty of Nursing, Sydney University to present lecture on The Dangers of Vaccination
1997 Participated at a public debate on vaccination at Sydney University in Sydney, Australia.
1997 to 1998 Invited to participate in the Training Program of the Royal Australian College of General Practitioners (RACOP), Sydney, New South Wales, as one of two expert panelists in debates on whether immunization should or should not be mandatory, presenting the case against vaccination based on the study of published orthodox medical research.
1998 Invited to address the Medical (MBOG) Congress in Utrecht, Holland on the Effect of Vaccination on the Immune System
1998 Invited to participate in a debate on vaccination convened by the organization WDDTY (What Doctors Don’t Tell You) in Londing, U.K.
Medical Journal Publications
[1] Scheibner V. Evidence of the association between non-specific stress syndrome, DPT injections, and cot death. Immunisation: The Old and the New. Proceedings of the Second National Immunisation Conference. Canbera, Public Health Association of Australia; May 27-29, 1991:90–1.
[2] Tye K, Pollard I, Karlsson L, Scheibner V, Tye G. Caffeine exposure in utero increases the incidence of apnea in adult rats. Reprod. Toxicol. 1993 Sep./Oct.;7(5):449–52.
[3] Scheibner V. Response to Leask and McIntyre’s attack on Viera Scheibner as a public opponent of vaccination. Vaccine, 2003 Dec. 8;:22(1):vi–ix.
Papers published in magazines, chiropractic journals, etc.
[1] Scheibner V, Karlsson L. Cot death and vaccination link. Natural Health Magazine 1991;4(5-6) Aug./Sept. and Oct./Nov. 1991:2-4.
[2] Scheibner V, Karlsson L. The vaccination debate. Natural Health Magazine 1991;4(5-6) Aug./Sep. and Oct./Nov. 191:5–8.
[3] Scheibner V. Facts about Haemophilus influenzae B vaccines: what every doctor—and all parents—should know about. Natural Health Magazine 1992 Oct./Nov.:1–3.
[4] Scheibner V. Cotwatch breathing monitor guards against cot death. Natural Health Magazine Dec. 1992-Jan. 1993:12e
[5] Scheibner V. Should I vaccinate my child? Natural Health Magazine Dec. 1992/Jan. 1993.
[6] Scheibner V. Flu vaccinaation—is it safe? Natural Health Magazine 1993 Jun./Jul.
[7] Scheibner V. Embracing vaccination...lamentably wrong! The chiropractic Journal (USA); Oct. 1994:41–5.
[8] Scheibner V. Chiropractic attitudes towards immunizatgion. International Chiropractic Association (USA); Sep./Oct. 1996:45–9.
[9] Scheibner V. Vaccination: Is prevention really the best cure? Conscious Living (Health) 1996::36–7.
[10] Scheibner V. Shaken Baby Syndrome diagnosis—on shaky ground. J ACEM 2001 Aug.;20(2):5–8, & 15.
[11] Scheibner V. Dynamics of critical days as part of the dynamics of non-specific stress syndrome discovered during monitoring with Cotwatch breathing monitor. J ACNEM 2004;23(3):10–4.
[12] Scheibner V. Cot deaths linked to vaccination. Nexus Magazine (Australia); 2(5), Oct./Nov. 1991.
[13] Scheibner V. Brain-eating bugs: the vaccination connection. Nexus Magazine (Australia); 3(3), Apr./May 1996.
[14] Scheibner V. Shaken Baby Syndrome: the vaccination link. Nexus Magazine (Australia); 5(5) Aug./Sept. 1998.
[15] Scheibner V. Adverse effects of adjuvants in vaccines. Part 1. Nexus Magazine (Australia); 8(1), Dec. 2000/Jan. 2001.
[16] Scheibner V. Adverse effects of adjuvants in vaccines. Part 2. Nexus Magazine (Australia); 8(2), Feb./Mar. 2001.
[17] Scheibner V. Vaccinations and the dynamics of critical days. Nexus Magazine (Australia);12(6) Oct./Nov. 2005. Reprinted from J ACNEM. Also reprinted by Nexus Magazine in France and other countries.
Letters to the Editor of Medical Observer (Australia) and Australian Doctor
[1] Scheibner V. Vaccination challenge. Medical Observer 1999 Mar. 19:24.
[2] Scheibner V. Why all the fear of the measles virus? Medical Observer 2001 Mar. 9:33.
[3] Scheibner V. Unreal world of the pro-vaccinators. Medical Observer 2001 April 6.
[4] Scheibner V. Study first, judge later. Australian Doctor 2003 May 2.
Letters to the Editor in BMJ.COM Rapid Responses
[1] Scheibner V. Unreliability of scientific papers as evidence. 2004 March 24. BMJ.
http://www.bmj.com/cgi/eletters/328/7440/602-c#54389
[2] Scheibner V. Patterns of presentation of the shaken baby syndrome may not be caused by trauma at all. 2004 April 2. BMJ.
http://bmj.bmjjournals.com/cgi/eletters/328/7442/766#55368
[3] Scheibner V. Study first, judge later. 2004 June 29. BMJ.
http://www.bmj.com/cgi/eletters/328/7451/1309#64944
[4] Scheibner V. Study first, judge later. 2004 July 3. BMJ.
http://www.bmj.com/cgi/eletters/328/7451/1309#64944
[5] Scheibner V. Some questions for Clive Davies or anyone. 2004 July 21. BMJ.
http://www.bmj.com/cgi/eletters/328/7451/1309#68034
[6] Scheibner V. History repeats itself because people forget history. 2004 Sep. 13. BMJ.
http://www.bmj.com/cgi/eletters/329/7463/411#74079
[7] Scheibner V. Gold standards. 2005 Feb. 8. BMJ.
http://www.bmj.com/cgi/eletters/330/7485/206?ck=nck#95978
[8] Scheibner V. The Richardson hypothesis. 2005 Feb. 10. BMJ.
http://www.bmj.com/cgi/eletters/330/7485/206#96219
[9] Scheibner V. A fatal misdiagnosis. 2005 Feb. 17. BMJ.
http://www.bmj.com/cgi/eletters/330/7485/216-b#96841
[10] Scheibner V. A fatal misdiagnosis. 2005 Feb. 22. BMJ.
http://www.bmj.com/cgi/eletters/330/7485/216-b#96841
[11] Scheibner V. Doctors don’t like the taste of their own medicine. 2005 Mar. 5. BMJ.
http://www.bmj.com/cgi/eletters/330/7489/485#99122
[12] Scheibner V. Intramuscular, not intravenous. 2005 Mar. 5. BMJ.
http://www.bmj.com/cgi/eletters/330/7483/112-d#99120
[13] Scheibner V. MMR and Japan: a commentary by Wakefield and Stott. 2005 Mar. 10. BMJ.
http://www.bmj.com/cgi/eletters/330/7483/112-d#99926
[14] Scheibner V. Epidemiology aint epidemiology (just like oils aint oils). 2005 Mar. 18. BMJ.
http://www.bmj.com/cgi/eletters/330/7491/558-a#100768
[15] Scheibner V. Simply a concerned parent: parents must do more research. 2005 Mar. 24. BMJ.
http://www.bmj.com/cgi/eletters/330/7491/552#101411
[16] Scheibner V. Existing research is revealing and accessible. 2005 Mar. 24. BMJ.
http://www.bmj.com/cgi/eletters/330/7491/552#101398
Books and booklets on vaccination issues
[1] Scheibner V. Vaccination 100 years of scientific research shows that vaccines represent a medical assault on the immune system. Victoria: Australian Print Group, 1993; pp 296.
[2] Scheibner V. Behavioural problems in childhood—the link to vaccination. 2000; pp 297. Also translated into Swedish by an organization of parents dealing with children’s health.
[3] Scheibner V. Answers to the CDC’s instructions how to counteract the anti-vaccination argument. 1998; pp 22.
Editor (Massachusettes, United States)
Eileen Nicole Simon, PhD, RN
Eileen Nicole Simon’s interests are: (a) The neurological basis of autism, schizophrenia, and “character” disorders, (b) Brainstem impairments, as in Wernicke’s encephalopathy, (c) How and why brainstem nuclei of high metabolic rate differ in vulnerability under different conditions of compromise, and (d) History of science. She received a doctorate in biochemistry from Boston University in 1975. After a long career in computer science, she returned to school for teacher certification and nursing. She has worked in the Massachusetts hospital for mentally ill prison inmates over the past 14 years and has become aware that many inmates had developmental disabilities. She notes that the majority left or quit school without skills or motivation to work. Deviant behaviors (some trivial, some tragic) led to incarceration—the costliest kind of long-term care! Prenatal exposure to drugs and alcohol, physical abuse and head injury account for some developmental problems, but many records contain mothers’ reports of oxygen deficiency and other complications at birth, information that merits greater consideration.
Education
● PhD, Biochemistry, Boston University, Boston MA
● MS, Mathematics, Northeastern University, Boston MA
● BA, Chemistry, Barnard College, New York NY
● Teacher Certification, UMASS Boston
● Nursing, Laboure College, Boston MA
Current Employment
● Instructional Aide, Special Education, Diamond Middle School, Lexington MA, since February 2005.
● Nurse & Mental Health Worker, Bridgewater State Hospital, Bridgewater MA, 1991-present
Former Career in Computer Science
● Software Engineer & Instructor, Digital Equipment Corporation (now Hewlett Packard), Littleton MA, 1979-1990
● Software Engineer, American Science & Engineering, Cambridge MA, 1977-1979
● Software Developer, Bolt Beranek & Newman, Cambridge MA, 1975-1977, 1991
● Programmer (EEG evoked potentials), Boston University School of Medicine, Boston MA, 1969-1971
● Programmer, Smithsonian Astrophysical Observatory, Cambridge MA, 1960-1969
Publications
[1] Simon EN. Auditory agnosia caused by a tectal germinoma. Neurology, 2005 Jul 26;65(2):339 [letter].
[2] Simon EN. Autism as a birth defect. Birth Defects Res Part A Clin Mol Teratol, 2004 Jun;70(6):416 [letter].
[3] Simon EN. The lessons of MMR. Lancet, 2004 May 1;363(9419):1473–4 [letter].
[4] Simon N. Autism's home in the brain. Neurol., 2000; 54:269–70 [letter].
[5] Simon N. Auditory dysfunction in autism: a submicroscopic form of Wernicke's encephalopathy? Journal of Autism and Developmental Disorders, 1999; 29:426–7 [letter].
[6] Simon N. The auditory system, brain maturation, and development in autistic children. Journal of Autism and Developmental Disorders, 1999;29:94–5 [letter].
[7] Simon N. Hemoglobin and the brain: a piece of the autism puzzle? Journal of Autism and Developmental Disorders, 1998; 28:579–80 [letter].
[8] Simon N. Autism and the inferior colliculus. Journal of Autism and Developmental Disorders, 1997; 27:494–6 [letter].
[9] Simon N. Infantile autism and Wernicke's encephalopathy. Medical Hypotheses, 1990; 32:169–72.
[10] Simon N. Kaspar Hauser's recovery and autopsy: A perspective on neurological and sociological requirements for language development. Journal of Autism and Childhood Schizophrenia, 1978;8:209–17. Reprinted in J. Money and G. Williams (eds.) Traumatic Abuse and Neglect of Children at Home, Chapter 6. Johns Hopkins Press: Baltimore, 1979:56–62. Also reprinted in S. Chess and A. Thomas (eds.), Annual Progress in Child Psychiatry and Child Development 1979, Vol. 12, Chapter 11, Brunner/Mazel: New York, 1979: 215–24.
[11] Simon N, Volicer L. Neonatal asphyxia in the rat: Greater vulnerability of males and persistent effects on brain monoamine synthesis. Journal of Neurochemistry, 1978;26:893–900.
[12] Simon N. Echolalic speech in childhood autism: Consideration of possible underlying loci of brain damage. Archives of General Psychiatry, 1975; 32:1439–46. Reprinted in S. Chess and A. Thomas (eds.) Annual Progress in Child Psychiatry and Child Development 1976, Vol. 9, Chapter 25, Brunner/Mazel: New York, 1977:471–90.
[13] Simon EN (1975) Long-term Effects of Neonatal Asphyxia in the Rat. Doctoral Dissertation, Boston University, Boston MA, 1974, 193 pp. University Microfilms, Ann Arbor MI. Available online at http://www.umi. com/umi/dissertations/ or http://wwwlib.umi.com/dxweb/gateway (Order No. 7505520).
Website : http://conradsimon.org/
Editor (New Mexico, United States)
Kenneth P. Stoller, MD
Kenneth P. Stoller, MD, Medical Director of the Hyperbaric Medical Center of New Mexico, is President of the International Hyper-baric Medical Association, a Fellow of the American Academy of Pediatrics, a Diplomat of the American Board of Pediatrics, a Diplomat of the American Board of Hyperbaric Medicine, a member of the American College for Hyperbaric Medicine. He was University of California President's Undergraduate Fellow in the UCLA Medical Center's Department of Anesthesiology, and a former Clinical Assistant Professor of Pediatrics, UNM School of Medicine Dr. Stoller is also part of the Divers Alert Network Physician Referral Network
Dr. Stoller is a founding board member of the International Hyperbaric Medical Association, and its current President. He was also a founding board member of the Humane Farming Association, Science Editor of the Animals' Voice Magazine where he was nominated for a Maggie. His Op-Ed pieces have appeared in several newspapers and periodicals from The Atlanta Constitution, Los Angeles Times, Abq Tribune to The Scientist. He has served on both the Injury Prevention Committee and the Environmental Hazards Committee of the American Academy of Pediatrics.
Experience
2001-2006
• Medical Director, Hyperbaric Medical Center of New Mexico
• Medical Director, Hyperbaric oxygen Clinic of Sacramento (2004-2006)
• Founding Board of Directors, International Hyperbaric Med Assoc (IHMA)
• President, IHMA, Officer, American Board Hyperbaric Medicine
• Clinical Assistant Professor, Pediatrics, UNM School of Med (2002-2005)
1999-2000
• Solo private practice, Santa Fe, New Mexico
• Director of Pediatric Medicine, Santa Fe County Youth Development Program. (Medical Director SFCCF Nov. 1999/Feb. 2000)
1998-1999
• Director, Clinica de Salud Para Ninos, Van Nuys, California
• Columnist for Nutrition Insights (Let’s Live Magazine)
• Visiting pediatrician Chickasaw Nation Hospital, Ada, OK
1986-1997
• Private Practice Recertified American Board of Ped. 1997, 2003
• Active Staff St. Joseph's Medical Center, Burbank CA;
• Vice Chairman of Pediatric Department (SJMC)
• Active Staff Huntington Memorial Hospital
• Environmental Hazard Committee Amer Acad of Pediatrics Chapt II
• Advisor, Medical Research Modernization Committee
1984-1986
• Injury Prevention Committee, Amer. Acad. of Pediatrics, District IX
• Founding Board of Directors Humane Farming Association
• Science Editor Animal’s Voice Magazine
1978-1981
• Consultant, Multiple Risk Factor Intervention Trial (MRFIT), USC School of Medicine
1975-1976
• Pre-doctoral Research Fellow, Department of Anesthesiology, UCLA School of Medicine
Publications
[1] Stoller KP. Quantification of neurocognitive changes before, and after hyperbaric oxygenation therapy in a case of fetal alcohol syndrome. Pediatrics, 2005 Oct;116(4):e586–91.
[2] Stoller KP. Autism Spectrum Disorders: An Update of Federal Gvernment Initiatives and Revolutionary New Treatments of Neurodevelopmental Diseases. Federal Register. Congressional Testimony before the U.S. House of Rep. Subcommittee on Human Rights and Wellness, May 6, 2004.
[3] Stoller KP. Restoration of Sudden Hearing Loss. Proceedings of the XIV International congress of Hyperbaric Medicine, Best Publishing Co., Flagstaff, AZ.
[4] Preface to Proceedings of the II International Symposium for cerebral Palsy & the Brain-injured child, Best Publishing Co., 2002, Flagstaff, AZ.
[5] Stoller KP. Baby Fae: The Unlearned Lesson. In: Perspectives on Medical Research. M Research Mod. Com., New York, 1990.
[6] Stoller KP. Rats! to Animal Models. In: Perspectives on Animal Research. M Research Mod. Com., New York, 1989.
[7] Stoller KP, Taff BE. Remote physiological sensing: historical perspective, theories and preliminary developments. Med. Instrum., 1986 Sep./Oct.; 20(5):260–5.
[8] Stoller KP, Brooks PG. Detection of ovulation via finger tip electrical potentials: a preliminary report. Mt. Sinai J. Med., 1986 Sep.;53(7):506–9.
[9] Ruderman JW, Stoller KP, Pomerance JJ. Bloodstream invasion with Shigella sonnei in an asymptomatic newborn infant. Pediatr. Infect. Dis., 1986 May-Jun.;5(3):379–80.
[10] Stoller KP, Losey R. Inadvertent intra-arterial injection of penicillin: an unseen danger. Pediatrics, 1985 Apr.;75(4):785–6.
[11] Doyle DE, Stoller KP. Intranasal airway/pack: description of a new device. Laryngoscope, 1983 June;93(6):808–9
[12] Stoller KP. Are we prepared to prevent cancer? In: Stress & Cancer, C.J. Hogrefe, Inc. Toronto, 1981.
[13] Stoller KP. Sewer science and pound seizure. International J for the Study of Animal Problems, 1981;5:241.
[14] Stoller K, Swanson GD, Bellville JW. Effects on visual tracking of Δ9-tetrahydrocannabinol and pentobarbital, 1976 May-Jun.;16(5-6):271–5.
[15] Stoller KP, Belleville JP, Bellville JW. Visual tracking following lorazepam or pentobarbital. Anesthesiology, 1976 Nov;45(5):565–8.
[16] Stoller, K. Shaughnessy, MF, Greathouse, DL. An Interview with Kenneth Stoller about Hyperbaric Medicine and Brain Injury Trauma. North American Journal of Psychology, 2005; 7(2):217–28.
Editor (Arizona, United States)
Tomas G. Teskey, DVM
Tomas G. Teskey received his D.V.M. in 1995 from Colorado State University and has been a private practitioner in Arizona since that time, taking a specialty approach to the equine hoof. He has studied the teachings of all other equine podiatrists that have contributed to the science over the last 200 years. Using specialized trimming techniques based on anatomical landmarks and extensive study of both feral and working horses, most diseased hooves can be brought to soundness and a higher level of performance. Abandoning the use of metal appliances, the nature of the equine hoof itself has become the focus for providing a solid foundation for domestic horses the world over. Dr. Teskey has held numerous workshops on hoof care across Arizona, has spoken to veterinary student audiences at Colorado State University, and continues to plan for engagements in the United States and Internationally.
Editor (Surrey, United Kingdom)
Andrew J. Wakefield, MB BS, FRCS, FRCPath
Dr. Wakefield currently serves as Executive Director, Thoughtful House Center for Children, Austin Texas, 78746. He received his medical education at St. Mary’s Hospital Medical School, London (1976-1981) and his MB BS degree from the University of London (1981). Dr. Wakefield completed primary and Final fellowship at the Royal College of Surgeons (London) during 1983 and 1985, respectively. He completed a fellowship of the Royal College of Pathologists (U.K.) in 2001.
Dr. Wakefield is the recipient of of the 1987 Toronto General Hospital Resident’s Research Prize, the 1988 First Prize from the Basic Science, Mount Sinai Hospital Department of Medicine (Toronto), the 1992-3 SMART I Award and 1993-4 SMART II Award for Research and Technology from the Department of Trade and Industry, and the 2000 NVIC Courage in Science Award.
Dr. Wakefield has been a reviewer to the following scientific journals: Lancet, American Journal of Gastroenterology, Gastroenterology, Gut, Digestive Diseases and Science, European Journal of Gastroenterology and Hepatology, Alimentary Pharmacology and Therapeutics.
Appointments
• House Surgeon to Mr. D. C. Britton, Royal United Hospitals, Bath, Avon, Aug 1981 - Feb 1982
• House Physician to Dr. J. G. Walker, Dr. R. Elkeles, Dr. C. Coulter and Professor Wickramasinghe, St. Mary’s Hospital, London, W2, Feb 1982 - Aug 1982
• Two year appointment to St. George’s Hospital, General Surgical Senior House Officer Rotation Casualty Officer, St. George’s Hospital, Tooting (Mr. A. Barker), Aug 1982 - Feb 1983
• The Royal Marsden Hospital, Sutton. Mr. J-C Gazet, Mr N Breech, Dr. J. Ford, Dr. J. Glees, Feb 1983 - Aug 1983
• Frimley Park Hospital, Surrey. Mr. A. H. Amery, Mr. H. Hills, Mr. K. P. R. Rutter, Mr. M. J. Solan, Mr. R. C. Lallemand, Aug 1983 - Aug 1984
• Two year appointment to Queen Mary’s University Hospital, Roehampton, Surgical Registrar Rotation:
• Registrar to Mr. R. A. D. Booth, General and Colorectal surgery, Sep 1984 - May 1985
• Registrar to Mr. K. P. Robinson, General and Vascular surgery, May 1985 - Jan 1986
• Registrar to Mr. J. McLean-Singleton, General and Urological surgery, Jan 1986 - Apr 1986
• Appointment to St. George’s Hospital, Tooting, Surgical Registrar Rotation
• Registrar to Miss E. M. Gordon, Paediatric surgery, Apr 1986 - Nov 1986
• Appointment as Wellcome Research Fellow to the Surgical Unit, Toronto General Hospital and the Faculty of Medicine of the University of Toronto, Toronto, Ontario, Canada: Dr. Z. Cohen and Professor B. Langer, Nov 1986 - Nov 1988
• Appointment as Wellcome Research Fellow, Royal Free School of Medicine, Nov 1988 – Sept 1990
• Senior Lecturer in Experimental Gastroenterology, Departments of Medicine & Histopathology Oct 1990 – Sept 1997
• Reader in Experimental Gastroenterology, Department of Medicine & Histopathology,Oct 1997 – Nov 2001,Royal Free & University College Medical School, London.
• Honorary Consultant in Experimental Gastroenterology to Royal Free Hampstead NHS Trust, London.
• Director of Research and Chairman, Inflammatory Bowel Disease Study Group, RFHSM.
• Senior Medical Adviser to the UK registered Charity VISCERAL, Dec 2001 Dec 2004
• Executive Director, Thoughtful House Center for Children, Austin Texas, Dec 2004 -
Honors, Scholarships and Awards
• Wellcome Trust Travelling Fellowship, 1986-9
• Runcorn Travelling Scholarship, Westminster Medical School Research Trust, 1986
• AMI Travelling Scholarship, Royal College of Surgeons, England, 1986
• Ethicon Foundation Scholarship, Ethicon; Foundation Fund, Royal College of Surgeons, England, 1986
• Anglo-Canadian Scientific Exchange Scholarship, The Royal Society and the Natural Sciences and Engineering Research Council, Canada, 1986-1987
• Wellcome Trust Travelling Fellowship, The Wellcome Trust, London, 1986-1989
• Curie Foundation Travelling Scholarship, 1989
• Three year extension of Wellcome Trust Fellowship, 1990-1993
• Membre D’Honneur Etranger de la Societem, Royal Belge de Gastro-Enterologie, 1995
• Fellow of the Royal Collage of Pathologists, 2001
Research and Development Interests
q The Inflammatory Bowel Disease Study Group
q The role of microvascular injury in the pathogenesis of inflammatory bowel disease.
q The role of the gut in childhood developmental disorders
Publications
[1] Mant TG, Lewis JL, Mattoo TK, Rigden SP, Volans GN, House IM, Wakefield AJ, Cole RS. Mercury poisoning after disc-battery ingestion. Hum Toxicol. 1987:6:179–81.
[2] Silverman R, Cohen Z, Craig M, Wakefield A, Kim P, Langer B, Levy G. Monocyte/macrophage procoagulant activity (PCA) as a measure of immune responsiveness in Lewis and Brown Norway inbred rats: discordance with lymphocyte proliferative assays. Transplantation 1989; 47: 542–8.
[3] Wakefield AJ, Gordon EM. A huge renal cyst presenting in childhood. Case report and review of the literature. J R Soc Med. 1989; 82: 443–5.
[4] Wakefield AJ, Cohen Z, Kim P, Craig M, Levy G. The reversal of cyclosporine mediated suppression of alloantigen induced monocyte procoagulant activity by H2 antagonists cimetidine and ranitidine in vitro. Transplantation Proceedings 1989; 21: 844–7.
[5] Kim P, Wakefield AJ, Cohen Z, Craig M, Levy G. The reversal of cyclosporine mediated suppression of monocyte procoagulantactivity by H2 antagonists in the rat model of small intestinal transplantation. Transplantation Proceedings 1989: 21; 2900–2.
[6] Wakefield AJ, Cohen Z, Craig M, Jeejeebhoy KN, Levy GA. The thrombogenicity of total parenteral nutrition solutions. I: Effect on induction of monocyte macrophage procoagulant activity. Gastro-enterology 1989; 97:1210–9.
[7] Wakefield AJ, Cohen Z, Craig M, Rosenthal A, Gotleib A, Jeejeebhoy KN, Levy GA. The thrombogenicity of total parenteral nutrition solutions. II: Effect on induction of endothelial cell procoagulant activity. Gastroenterology 1989; 97:1220–8.
[8] Wakefield AJ, Sawyerr AM, Dhillon AP, Pittilo RM, Rowles PM, Lewis AAM, Pounder RE. Pathogenesis of Crohn’s disease: multifocal gastrointestinal infarction. Lancet 1989; ii:1057–62.
[9] Sinclair S, Wakefield AJ, Levy GA Fulminant hepatic failure. Springer Seminars in Immunopathology, (ed) Thomas HC 1990; 12:33–45
[10] Wakefield AJ, Cohen Z, Levy GA. Procoagulant activity in Gastroenterology. Gut 1990; 31:239–42.
[11] Sawyerr AM, Wakefield AJ, Hudson M, Dhillon AP, Pounder RE. The pharmacological implications of leucocyte-endothelial cell interactions in Crohn’s disease. Alimentary Pharmacology & Therapeutics 1990; 1:1–14.
[12] Wakefield AJ, Dhillon AP, Sawyerr AM, Sankey E, More, L, Sim R, Pittilo RM, Rowles PM, Hudson M, Lewis AAM, Pounder RE. Granulomatous vasculitis in Crohn’s disease. Gastroenterology 1991; 100:1279–87.
[13] Wakefield AJ, Sawyerr AM, Hudson M, Dhillon AP, Pounder RE. Smoking, the oral contraceptive pill and Crohn’s disease. Dig Dis Sci. 1991; 36:1147–50.
[14] Kelleher J, Wakefield AJ, Gordon I, Ransley P. Renal injury in complete ureteric obstruction: a functional and morphological study. Urol Res. 1991; 19:245–8.
[15] Pounder RE, Wakefield AJ, Sawyerr AM, Hudson M, Dhillon AP. Pathogenesis of Crohn’s disease: granulomatous vasculitis and multifocal gastrointestinal infarction Proceedings of the Falk Symposium on Inflammatory Bowel Disease 1991; 5:33–8.
[16] Kelleher JP, Shah V, Godley M, Wakefield AJ, Gordon I, Ransley PG, Snell ME, Risdon RA. Urinary endothelium (ET-1) in complete ureteric obstruction in the miniature pig. Urol Res. 1992; 20:63–5.
[17] Wakefield AJ, Fox JD, Sawyerr AM, Taylor JE, Sweenie CH, Smith M, Emery V, Hudson M, Tedder RS, Pounder RE. Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn’s disease using the nested polymerase chain reaction. J Med Virol. 1992; 38:183–90.
[18] Wakefield AJ, Hudson M, Pounder RE. Crohn’s Conflict (Invited article). Medical Laboratory World 1992; 5:9–13.
[19] Hudson M, Piasecki C, Sankey EA, Sim R, Wakefield AJ, More LJ, Sawyerr AM, Dhillon AP, Pounder RE. A ferret model of acute multifocal gastrointestinal infarction. Gastroenterology 1992;102:1591–6.
[20] Dhillon AP, Anthony A, Sim R, Wakefield AJ, Sankey EA, Hudson M, Allison MC, Pounder RE. Mucosal capillary thrombi in rectal biopsies. Histopathology 1992; 21:127–33.
[21] Hudson M, Hutton R, Wakefield AJ, Sawyerr AM, Pounder RE. Evidence for activation of coagulation in Crohn’s disease. Blood Coagulation and Fibrinolysis 1992; 3:773–8.
[22] Hudson M, Wakefield AJ, Hutton RA, Sankey EA, Dhillon AP, More L, Sim R, Pounder RE Factor XIIIa subunit and Crohn’s disease. Gut 1993; 34:75–9.
[23] Wakefield AJ, Hudson M, More L. Procoagulant activity in gastro-enterology. In: Procoagulant Activity in Health and Disease. Eds: Levy GA; Cole EH. CRC Press: Ann Arbor, USA. 1993;5:87–110.
[24] Sankey EA, Dhillon AP, Anthony A, Wakefield AJ, Sim R, More L, Hudson M, Sawyerr AAM, Pounder RE. Early mucosal changes in Crohn’s disease. Gut 1993; 34:375–81.
[25] Osborne M, Hudson M, Piasecki C, Dhillon AP, Lewis AAM, Pounder RE, Wakefield AJ. Crohn’s disease and anastomotic recurrence: microvascular ischaemia and anastomotic healing in an animal model. Br J Surg. 1993; 80:226–9.
[26] Anthony A, Dhillon AP, Nygård G, Hudson M, Piasecki C, Strong P, Trevethick MA, Clayton NM, Jordan CC, Pounder RE, Wakefield AJ. Early histological features of small intestinal injury induced by indomethacin. Alimentary Pharmacology &.Therapeutics.1993;7:29–39.
[27] Wakefield AJ, Pittilo RM, Sim R, Cosby SL, Stephenson JR, Dhillon AP, Pounder RE. Evidence of persistent measles virus infection in Crohn’s disease. Journal of Medical Virology. 1993; 39:345-353.
[28] Smith M, Wakefield AJ. Viral association with Crohn’s disease: Invited article. Annals of Medicine 1993; 25:557–61.
[29] More L, Sim R, Hudson M, Dhillon AP, Pounder RE, Wakefield AJ. Immunohistochemical study of tissue factor expression in normal intestine and idiopathic inflammatory bowel disease. J Clin Pathol. 1993;46:703–8.
[30] Wakefield AJ, More L, Difford J, McLaughlin JE. Immunohisto-chemical study of vascular injury in acute multiple sclerosis. J Clin Pathol. 1994; 47:129–33.
[31] Hudson M, Piasecki C, Wakefield AJ, Sankey EA, Dhillon AP, Osborne M, Sim R, Pounder RE. A vascular hypersensitivity model of acute multifocal intestinal infarction. Dig Dis Sci. 1994; 39:534–9.
[32] Nygård G, Anthony A, Piasecki C, Trevethick MA, Hudson M, Dhillon AP, Pounder RE, Wakefield AJ. Acute indomethacin-induced jejunal injury in the rat: early morphological and biochemical changes. Gastroenterology 1994; 106:567–75.
[33] Mazure G, Grundy JE, Nygård G, Hudson M, Khan K, Srai K, Dhillon AP, Pounder RE, Wakefield AJ. Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro. J Gen Virol. 1994; 75:2863–71.
[34] Hamilton MI, Wakefield AJ. Inflammatory bowel disease. Recent Advances in Gastroenterology. Vol. 10 Ed. RE Pounder. Churchill Livingstone. London 1994. Vol. 10 9:161–80.
[35] Thompson NP, Wakefield AJ. Infective agents -Vascular factors Inflammatory Bowel Disease. Ed. Allan RN, Keighley MRB, Rhodes J. Alexander Williams J. 1994;17:133–42.
[36] Ekbom A, Wakefield AJ, Zack M, Adami H-O. Perinatal measles infection and subsequent Crohn’s disease. Lancet 1994; 344: 508-510.
[37] Sawyerr AM, Pottinger BE, Savage CO, Bradley NJ, Hudson M, Wakefield AJ, Pearson JD, Pounder RE. Serum immunoglobulin G reactive with endothelial cells in inflammatory bowel disease. Dig Dis Sci. 1994; 39:1909–17.
[38] Anthony A, Dhillon AP, Sim R, Pounder RE, Wakefield AJ. Dexamethasone promotes ulcer plugging in experimental enteritis. Alimentary Pharmacol & Therapeutics 1994; 8:597–602.
[39] Smith M, Wakefield AJ. Crohn’s disease: ancient and modern. Invited article. Journal of Postgraduate Medicine. 1994; 70:149–53.
[40] Anthony A, Dhillon AP, Sim R, Nygård G, Pounder RE, Wakefield AJ. Ulceration, fibrosis and diaphragm-like lesions in the caecum of rats treated with Indomethacin Aliment Pharmacol Ther. 1994; 8:417–24.
[41] Wakefield AJ. The pathogenesis of Crohn’s disease. Chronic Inflammatory Bowel Disease. Stangë EF (Ed), Kluwer Academic Publishers, London, 1994:22–9
[42] Wakefield AJ, Hudson M, Pounder RE Leukocyte-endothelial cell interactions in Crohn’s disease: potential targets for mesalazine in Crohn’s disease.Advances in Experimental Medicine and Biology 1995. Ed: McGhee JR and Mestecky J. Plenum Press, New York:1307–11.
[43] Ray RA, Smith M, Sim R, Nystrom M, Pounder R E, Wakefield AJ. The intracellular polymerase chain reaction for small CMV genomic sequences within heavily infected cellular sections. J Pathol. 1995; 177:171–80.
[44] Ray RA, Smith M, Sim R, Bruce I, Wakefield AJ. In situ hybridisation detection of short viral amplicon sequences within cultured cells and body fluids after the in situ polymerase chain reaction. J Virol Methods 1995; 52:247–63.
[45] Nygård G, Hudson M, Mazure G, Anthony A, Dhillon AP, Pounder RE, Wakefield AJ Procoagulant and prothrombotic response of human endothelium to indomethacin and endotoxin in vitro: relevance to non-steroidal inflammatory drug enteropathy. Scan J Gastroenterol. 1995; 30:25–32.
[46] Nygård G, Anthony A, Khan K, Bounds SV, Dhillon AP, Pounder RE, Wakefield AJ. Intestinal site-dependent susceptibility to chronic indomethacin in the rat: a morphological and biochemical study. Aliment PharmacolTher. 1995; 9:403–10.
[47] Wakefield AJ, Ekbom A, Dhillon AP, Pittilo RM, Pounder RE. Crohn’s disease: pathogenesis and persistent measles virus infection. Gastroenterology 1995;108:911–6.
[48] Thompson N, Wakefield AJ, Pounder RE. Inherited disorders of coagulation appears to protect against inflammatory bowel disease. Gastroenterology 1995; 108:1011–5.
[49] Hamilton MI, Dick R, Crawford L, Thompson NP, Pounder RE, Wakefield AJ. Is proximal demarcation of ulcerative colitis determined by the territory of the inferior mesenteric artery? Lancet 1995;345:688–90.
[50] Hamilton MI, Bradley NJ, Srai SKS, Thrasivoulou C, Pounder RE, Wakefield AJ. Autoimmunity in ulcerative colitis: tropomyosin is not the major antigenic determinant of the Das monoclonal antibody, 7E12H12. Clinical & Experimental Immunology.1995; 99:404–11.
[51] Thompson NP, Wakefield AJ, Pounder RE. Prognosis and prognostic risk factors in inflammatory bowel disease. Special article. Saudi Journal of Gastroenterology. 1995;1:129–37.
[52] Lewin J, Dhillon AP, Sim R, Pounder RE, Wakefield AJ. Persistent measles virus infection of the intestine: confirmation by immunogold electron microscopy. Rapid publication. Gut 1995; 36:564–9
[53] Thompson NP, Montgomery SM, Pounder RE, Wakefield AJ. Is measles vaccination a risk factor for inflammatory bowel disease? Lancet 1995; 345:1071–4.
[54] Anthony A, Dhillon AP, Thrasivoulou C, Pounder RE, Wakefield AJ. Pre-ulcerative villus contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. Alimentary Pharmacology & Therapeutics. 1995;9:605–13.
[55] Anthony A, Dhillon AP, Fidler H, McFadden JJ, Billington O, Nygård G, Pounder RE, Wakefield AJ. Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats. International Journal of Experimental Pathology. 1995; 76:149–55.
[56] Smith MS, Warren BF, Fox JD, Watkins PE, Hudson M, Pounder RE, Wakefield AJ. Detection of herpesvirus DNA in cotton-top tamarins: no association with colitis. International Journal of Experimental Pathology. 1995;76:201–3.
[57] Sawyerr AM, Smith MS, Hall A, Hudson M, Hay CR, Wakefield AJ, Brook MG, Tomura H, Pounder RE. Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases. Digestive Diseases & Sciences. 1995; 40:793–9.
[58] Wakefield AJ. Vasculitis and Crohn’s disease: a novel and debated concept. Research and Clinical Forums. 1995; 17:53–6.
[59] Wakefield AJ. Crohn’s disease - the pathogenesis of a granulomatous vasculitis: A hypothesis. Canadian Journal of Gastroenterology 1995; 9:199–202.
[60] Ray R, Cooper PJ, Wakefield AJ. The era of intracellular nucleic acid technology. Biotechnology. 1995; 13:445–7.
[61] Thompson NP, Pounder RE, Wakefield AJ. Perinatal and childhood risk factors for inflammatory bowel disease: a case-control study. European Journal of Gastroenterology and Hepatology. 1995; 7:385–90.
[62] Wakefield AJ, Pounder RE. Measles virus in Crohn’s disease (Letter). Lancet 1995;345:660.
[63] Anthony A, Sim R, Dhillon AP, Pounder RE, Wakefield AJ. Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat. Gut 1996; 39:363–8
[64] Ekbom A, Daszak PS, Kraaz W, Wakefield AJ. Crohn’s disease following measles virus exposure in utero: risk estimates and clinical characteristics. Lancet 1996; 344:508–9.
[65] Ray R, Cooper PJ, Sim R, Chadwick N, Earle P, Dhillon AP, Pounder RE, Wakefield AJ. Direct in situ reverse transcriptase polymerase chain reaction for detection of measles virus. Journal of Virological Methods 1996;60:1–17.
[66] Anthony A, Bahl A, Oakley IG, Spraggs CF, Dhillon AP, Trevethick MA, Piasecki C, Pounder RE, Wakefield AJ. The beta-3 adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. Journal of Pathology 1996; 179:340–6.
[67] Hudson M, Chitolie A, Hutton RA, Smith MS, Pounder RE, Wakefield AJ. Thrombotic vascular risk factors in inflammatory bowel disease. Gut 1996;38:733–7.
[68] Ray R, Sim R, Khan K, Dhillon AP, Pounder RE, Wakefield AJ. Direct in situ nucleic acid amplification: control of artifact and use of labelled primers. Clinical Molecular Pathology 1996; 49: 345–50.
[69] Thompson N, Driscoll R, Pounder RE, Wakefield AJ. Genetics versus environment in inflammatory bowel disease: results of a British twin study. British Medical Journal 1996; 312:95–6.
[70] Thompson NP, Fleming DM, Pounder RE, Wakefield AJ. Crohn’s disease, measles and measles vaccination: a case-control failure (letter). Lancet 1996;347:263.
[71] Walmsley RS, Zhao MH, Hamilton MI, Brownlee A, Chapman P, Pounder RE, Wakefield AJ, Lockwood CM. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability increasing protein in inflammatory bowel disease. Gut 1997;40:105–9.
[72] Daszak P, Purcell M, Lewin J, Dhillon AP, Pounder RE, Wakefield AJ. Detection and comparative analysis of persistent measles virus infection in Crohn’s disease by immunogold electron microscopy. Journal of Clinical Pathology 1997;50:299–304.
[73] Wakefield AJ, Sim R, Akbar AN, Pounder RE, Dhillon AP. In situ immune responses in Crohn’s disease: a comparison with acute and persistent measles virus infection. Journal of Medical Virology. 1997; 51:90–100.
[74] Anthony A, Dhillon AP, Pounder RE, Wakefield AJ. Ulceration of the ileum in Crohn’s disease: correlation with vascular anatomy. Journal of Clinical Pathology.1997;50:1013–7.
[75] Anthony A, Pounder RE, Dhillon AP, Wakefield AJ. Vascular anatomy defines sites of indomethacin-induced jejunal ulceration along the mesenteric margin. Gut 1997;41:763–70.
[76] Montgomery SM & Wakefield AJ. Measles vaccine and neurological events. Lancet 1997; 349:1625. (Letter)
[77] Montgomery SM, Pounder RE, Wakefield AJ. Infant mortality and the incidence of inflammatory bowel disease. Lancet 1997; 349:472–3.
[78] Montgomery SM, Morris DL, Pounder RE, Wakefield AJ. Measles vaccination and inflammatory bowel disease (Letter). Lancet 1997; 350:1774.
[79] Tiwana H, Wilson C, Walmsley RS, Wakefield AJ, Smith MSH, Cox NL, Hudson MJ, Ebringer A. Antibody responses to gut bacteria in ankylosing spondylitis, rheumatoid arthritis, Crohn’s disease and ulcerative colitis. Rheumatology International. 1997; 17:11–6.
[80] Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal lymphoid nodular hyperplasia, non-specific colitis and pervasive developmental disorder in children. Lancet 1998;351:637–41.
[81] Kelly DA, Piasecki C, Anthony A, Dhillon AP, Pounder RE, Wakefield AJ. Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat. Gut 1998;42:366–73.
[82] Montgomery SM, Morris DL, Thompson NP, Subhani J, Pounder RE, Wakefield AJ. Prevalence of inflammatory bowel disease in British 26-year olds. British Medical Journal 1998;7137:1058–9.
[83] Balzola F, Khan K, Pera, A, Bonino F, Pounder RE, Wakefield AJ. Measles IgM immunoreactivity in patients inflammatory bowel disease. Italian Journal of Gastroenterol. 1998;30:4,378–82.
[84] Tiwana H, Walmsley RS, Wilson C, Yiannakou JY, Ciclitira PJ, Wakefield AJ, Ebringer A. Characterisation of the Humoral Immune Response to Klebsiella Species in Inflammatory Bowel Disease and Ankylosing Spondylitis. British Journal of Rheumatology. 1998; 37;525–31.
[85] Anthony A, Schepelmann S, Guillaume J-L, Strosberg AD, Dhillon AP, Pounder RE, Wakefield AJ. Localisation of the beta3-adrenoceptor in the human gastrointestinal tract: an immunohistochemical study. Alimentary Pharmacology & Therapeutics. 1998;12:579–626.
[86] Chadwick N, Bruce I, Davies M, van Gemen B, Schukkink R, Khan K, Pounder RE, Wakefield AJ. A sensitive and robust method for measles RNA detection. Journal of Virological Methods. 1998,70:59–67.
[87] Chadwick N, Bruce IJ, Schepelmann S, Pounder RE, Wakefield AJ. Measles virus RNA is not detected in inflammatory bowel disease using hybrid capture and reverse transcription followed by the polymerase chain reaction. Journal of Medical Virology, 1998;55:305–11.
[88] Walmsley RS, Anthony A, Sim R, Pounder RE, Wakefield AJ. Absence of E. Coli, Listeria and Klebsiella pneumoniae within inflammatory bowel disease tissues. Journal of Clinical Pathology. 1998;51:657–61.
[89] Kelly D, Piaseki C, Anthony, A, Dhillon AP, Ponder RE, Wakefield AJ. Reversal and protection against indomethacin-induced blood stasis and mucosal damage in the rat jejunum by a B-3 adrenoceptor agonist. Alimentary Pharmacology & Therapeutics. 1998; 12:1121–9.
[90] Wakefield AJ & Montgomery SM. Crohn’s disease: the case for measles virus (Invited article) Italian Journal of Gastroenterology 1999; 31:247–54.
[91] Chadwick N, Wakefield AJ, Pounder RE, Bruce I. A comparison of three nucleic acid amplification methods as a source for DNA sequencing. BioTechniques 1998;25:818–22.
[92] Montgomery SM, Morris DL, Pounder RE, Wakefield AJ. Paramyxivorus infections in childhood and subsequent inflammatory bowel disease. Gastroenterology 1999;116:796–803.
[93] Tompson NP, Fleming DM, Charlton J, Pounder RE, Wakefield AJ. Patients Consulting with Crohn’s disease in primary care in England and Wales. European Journal of Gastroenterology & Hepatology. 1998; 10:1007–12
[94] Anthony A, Dhillon AP, Pounder RE, Wakefield AJ. The colonic mesenteric margin is most susceptible to injury in an experimental model of colonic ulceration. Alimentary Pharmacology & Therapeutics. 1999; 13:531–5.
[95] Anthony A, Sim R, Pounder RE, Dhillon AP, Wakefield AJ. Similarities between Crohn’s disease and indomethacin experimental ulcers in the rat. Alimentary Pharmacology and Therpeutics. 2000;14:241–5.
[96] Subhani J, Montgomery SM, Thompson N, Ebrahim S, Wakefield AJ, Pounder RE. Childhood risk factors for inflammatory bowel disease: a twin case-control study. Submitted for publication.
[97] Montgomery SM, Twamley SI, Murch SH, Pounder RE, Wakefield AJ Contact with soil in infancy does not protect against atopy. Immunology Today 1999;20:289–90.
[98] Montgomery SM, Morris DL, Pounder RE, Wakefield AJ. Asian ethnic origin and the risk of inflammatory bowel disease. European.Journal of Gastroenterology and Hepatology.1999;11:543–6.
[99] Montgomery SM, Pounder RE, Wakefield AJ. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet 1999;353:379.
[100] Montgomery SM, Wakefield AJ, Morris DL, Pounder RE, Murch SH. The initial care of newborn infants and subsequent hay fever. Allergy. 2000;55:916–22.
[101] Orteu CH, McGregor JM, Whittaker SJ, Balzola F, Wakefield AJ. Erythema elevatum diutinum and Crohn disease: a common pathogenic role for measles virus? Arch Dermatol. 1996;32:1523–5.
[102] Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, Walker-Smith JA. Enterocolitis in children with developmental disorder. American Journal of Gastroenterology 2000;95:2285–95.
[103] Furlano RI, Anthony A, Day R, Brown A, McGavery L, Thomson MA, Davies SE, Berelowitz M, Forbes A, Wakefield AJ, Walker-Smith JA, Murch SH. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. Journal of Pediatrics 2001; 138:366–72.
[104] Wakefield AJ, Montgomery SM. Autism, viral infection and measles mumps rubella vaccination. Israeli Medical Association Journal 1999; 1:183–7.
[105] Dunn AC, Walmsley RS, Dedrick RL, Wakefield AJ, Lockwood CM. Anti-neutrophil cytoplasmic autoantibodies (ANCA) to bactericidal/ permeability-increasing (BPI) protein recognize the carboxyl terminal domain. Journal of Infection. 1999;39:81–7.
[106] Thompson NP., Montgomery SM., Wadsworth MEJ., Pounder RE., Wakefield AJ. Early determinants of inflammatory bowel disease: use of two longitudinal birth cohorts. European Journal of Gastroenterology & Hepatology. 2000;12:25–30.
[107] Kawashima H, Takayuki M, Kashiwagi Y, Takekuma K, Hoshika A, Wakefield AJ. Detection and sequencing of measles virus from peripheral blood mononuclear cells from patients with inflammatory bowel disease and autism. Digestive Diseases and Sciences. 2000;45:723–9.
[108] Wakefield AJ, Montgomery SM. Measles, mumps, rubella vaccine: through a glass, darkly. Adverse Drug Reactions & Toxicological Reviews 2000;19:265–83.
[109] Anthony A, Dhillon AP, Pounder RE, Wakefield AJ. Granulomatous vasculitis in Crohn’s disease: association with the extra-mural vasculature. 2001 (Submitted for publication)
[110] Morris DL, Montgomery SM, Galloway ML, Pounder RE, Wakefield AJ. Inflammatory bowel disease and laterality: is left handedness a risk? Gut. 2001;49:199–202.
[111] Wakefield AJ, Montgomery SM. Immunohistochemical analysis of measles related antigen in Inflammatory bowel disease. Gut. 2001; 48:136–7.
[112] Morris DL, Montgomery SM, Thompson NP, Ebrahim S, Pounder RE, Wakefield AJ. Measles vaccination and inflammatory bowel disease: a national British Cohort Study. American Journal of Gastroenterology. 2000;95:3507–12.
[113] O’Leary JJ, Uhlmann V, Wakefield AJ. Measles virus and autism. Lancet. 2000;356:772. (Letter).
[114] Wakefield AJ, Montgomery SM. Measles virus as a risk for inflammatory bowel disease: an unusually tolerant approach. American Journal of Gastroenterology. 2000;95:1389–92. (Editorial)
[115] Anthony A, Sim R, Guillaume JL, Strosberg AD, Dhillon AP, Pounder RE, Wakefield AJ. Beta (beta)3-adrenergic receptors in human pancreatic islet and duodenal somatostatin neuroendocrine cells. Alimentary Pharmacology and Therapeutics. 2000;14:579–80.
[116] Kelly D, Anthony A, Piasecki C, Lewin J, Pounder RE, Wakefield AJ. Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat. Alimentary Pharmacology and Therapeutics. 2000;14:489–96.
[117] Wakefield AJ. MMR vaccination and autism. Lancet. 1999;354:949–50. (Letter)
[118] Wakefield AJ. The New Autism. (Invited Article) Clinical Child Psychology & Psychiatry 2002;7:518–28.
[119] Uhlmann V, Martin C, Shiels, Wakefield AJ, O’Leary JJ. Possible viral pathogenesis of a novel paediatric inflammatory bowel disease. Molecular Pathology 2002;55:84–90.
[120] Wakefield AJ, Puleston J, Montgomery SM, Anthony A, O’Leary JJ, Murch SH Entero-colonic encephalopathy, autism and opioid receptor ligands. Alimentary Pharmacology & Therapeutics. 2002;16:663–74.
[121] Torrente F, Machado N, Perez-Machado M, Furlano R, Thomson M, Davies S, Wakefield AJ, Walker-Smith JA, Murch SH. Enteropathy with T cell infiltration and epithelial IgG deposition in autism. Molecular Psychiatry. 2002;7:375–82.
[122] Ehlin GGC, Montgomery SM, Ekbom A, Pounder RE, Wakefield AJ. The prevalence of gastrointestinal diseases in two British birth cohorts 2002.
[123] Montgomery SM, Wakefield AJ, Ekbom A. Pertussis infection in childhood and type I diabetes 2002 Diabet. Med. 2002;19: 986–93
[124] Montgomery SM., Lambe M., Wakefield AJ., Pounder RE., Ekbom A. Siblings and the risk of Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 2002;37:1301–8.
[125] Wakefield AJ. The gut-brain axis in childhood developmental disorders. Journal of Pediatric Gastroenterology and Nutrition. 2002;34:S14–S17.
[126] Wakefield AJ. Entero-colitis, Autism and Measles virus. Consensus in Child Neurology. 2002;6:74–7.
[127] Ashwood P, Anthony A, Pellicer AA, Torrente F, Wakefield AJ. Intestinal lymphocyte populations in children with regressive autism: Evidence for extensive mucosal immunopathology. Journal of Clinical Immunology, 2003;23:504–17.
[128] Wakefield AJ. Enterocolitis, autism and measles virus. Molecular Psychiatry. 2002;7:S44–6.
[129] Ashwood P, Anthony A, Torrente F, Wakefield AJ., Spontaneous mucosal lymphocyte cytokine profiles in children with regressive autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Clinical Immunology. 2004:24:664–73.
[130] Anthony A, Ashwood P, Wakefield AJ. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. European Journal of Gastroenterology and Hepatology 2004. (In press)
[131] Bradstreet JJ, El Dahr J, Anthony A, Kartzinel J, Wakefield AJ, Detection of Measles virus genomic RNA in cerebrospinal fluid of children with regressive autism: a report of three cases. Journal of American Physicians and Surgeons. 2004.9:39–45.
[132] Stott C, Blaxill M, Wakefield AJ. MMR and autism in perspective: the Denmark story. Journal of American Physicians and Surgeons 2004; 9:89–91.
[133] Wakefield AJ, Collins I, Ashwood P. The gut-brain axis in childhood developmental disorders: viruses and vaccines. Invited chapter in Infectious Disease and Neuropsychiatric Disorders. (In press)
[134] Ashwood P, Wakefield AJ. Ileal and peripheral blood CD3+ cytokine profiles in children with regressive autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Neuroimmunology. 2005. (In press)
[135] Wakefield AJ, Stott C, Limb K. Gastrointestinal comorbidity, autistic regression and Measles-containing vaccines. Medical Veritas 2006; 3(1):796–802.